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Tomas Hökfelt

Tomas Hökfelt

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Best Scientists
2025
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Medicine
Sweden
2026

D-Index & Metrics

Best Scientists

D-Index
197
Citations
149038
World Ranking
328
National Ranking
4

Neuroscience

D-Index
198
Citations
152416
World Ranking
33
National Ranking
2

Medicine

D-Index
198
Citations
152464
World Ranking
197
National Ranking
2

Research.com Recognitions

  • 2026 - Research.com Medicine in Sweden Leader Award
  • 2026 - Research.com Neuroscience in Sweden Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Medicine in Sweden Leader Award
  • 2025 - Research.com Neuroscience in Sweden Leader Award
  • 2023 - Research.com Medicine in Sweden Leader Award
  • 2022 - Research.com Medicine in Sweden Leader Award
  • 2022 - Research.com Neuroscience in Sweden Leader Award
  • 2011 - Member of the National Academy of Medicine (NAM)
  • 2002 - Robert J. and Claire Pasarow Foundation Medical Research Award
  • 1996 - Fellow of the American Academy of Arts and Sciences
  • 1989 - Member of Academia Europaea
  • 1984 - Member of the National Academy of Sciences
  • Foreign Member, Chinese Academy of Sciences
  • Foreign Member, Chinese Academy of Sciences
  • Foreign Member, Chinese Academy of Sciences
  • Foreign Member, Chinese Academy of Sciences
  • Foreign Member, Chinese Academy of Sciences

Overview

Tomas Hökfelt is affiliated with the Karolinska Institute in Sweden. Their research primarily spans the fields of Neuroscience and Biochemistry, Genetics and Molecular Biology, with significant contributions in subfields including Cellular and Molecular Neuroscience, Molecular Biology, Endocrine and Autonomic Systems, Physiology, and Neurology.

The main topics investigated by Tomas Hökfelt encompass:

  • Neuropeptides and Animal Physiology
  • Receptor Mechanisms and Signaling
  • Neuroscience and Neuropharmacology Research
  • Regulation of Appetite and Obesity
  • Single-cell and Spatial Transcriptomics
  • Stress Responses and Cortisol
  • Circadian Rhythm and Melatonin

Notable recent publications include:

  • "An atlas of the protein-coding genes in the human, pig, and mouse brain", 2020, Science
  • "Molecular design of hypothalamus development", 2020, Nature
  • "Disorganization and degeneration of liver sympathetic innervations in nonalcoholic fatty liver disease revealed by 3D imaging", 2021, Science Advances
  • "Spatiotemporal characterization of cellular tau pathology in the human locus coeruleus-pericoerulear complex by three-dimensional imaging", 2022, Acta Neuropathologica
  • "The neuropeptide landscape of human prefrontal cortex", 2022, Proceedings of the National Academy of Sciences

Frequent co-authors working alongside Tomas Hökfelt include:

  • Tibor Harkany
  • Mathias Uhlén
  • Jan Mulder
  • Swapnali Barde
  • Wen Zhong

The scientist has published regularly in several venues, with multiple works appearing in:

  • Proceedings of the National Academy of Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Molecular Psychiatry
  • Acta Physiologica

Tomas Hökfelt has received several distinguished recognitions including:

  • Member of the National Academy of Medicine (NAM), 2011
  • Robert J. and Claire Pasarow Foundation Medical Research Award, 2002
  • Fellow of the American Academy of Arts and Sciences, 1996
  • Member of Academia Europaea, 1989
  • Member of the National Academy of Sciences, 1984
  • Foreign Member, Chinese Academy of Sciences

Best Publications

  • Distribution of substance P-like immunoreactivity in the central nervous system of the rat—I. Cell bodies and nerve terminals

    Å. Ljungdahl;T. Hökfelt;G. Nilsson

  • Substance p: localization in the central nervous system and in some primary sensory neurons

    Tomas Hökfelt;Jan Olof Kellerth;Göran Nilsson;Bengt Pernow

  • Neuropeptide Y (NPY)‐like immunoreactivity in peripheral noradrenergic neurons and effects of NPY on sympathetic function

    Jan M. Lundberg;Lars Terenius;Tomas Hökfelt;Claes R. Martling

  • Distribution of peptide- and catecholamine-containing neurons in the gastro-intestinal tract of rat and guinea-pig: immunohistochemical studies with antisera to substance P, vasoactive intestinal polypeptide, enkephalins, somatostatin, gastrin/cholecystokinin, neurotensin and dopamine beta-hydroxylase.

    Schultzberg M;Hökfelt T;Nilsson G;Terenius L

  • Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia

    Juha Yrjänheikki;Riitta Keinänen;Milla Pellikka;Tomas Hökfelt

  • Experimental immunohistochemical studies on the localization and distribution of substance P in cat primary sensory neurons.

    Tomas Hökfelt;Jan-Olof Kellerth;Göran E. Nilsson;Bengt Pernow

  • An atlas of the protein-coding genes in the human, pig, and mouse brain

    Evelina Sjöstedt;Evelina Sjöstedt;Wen Zhong;Linn Fagerberg;Max J. Karlsson

  • Evidence for dopamine receptor stimulation by apomorphine

    Nils-Erik Andén;Allan Rubenson;Kjell Fuxe;Tomas Hökfelt

  • Immunohistochemical evidence for separate populations of somatostatin-containing and substance P-containing primary afferent neurons in the rat.

    T. Hökfelt;T. Hökfelt;R. Elde;R. Elde;O. Johansson;O. Johansson;R. Luft;R. Luft

  • Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P

    T. Hökfelt;Å. Ljungdahl;L. Terenius;R. Elde

  • Immunohistochemical support for three putative transmitters in one neuron: Coexistence of 5-hydroxytryptamine, substance p- and thyrotropin releasing hormone-like immunoreactivity in medullary neurons projecting to the spinal cord

    O. Johansson;T. Hökfelt;B. Pernow;S.L. Jeffcoate

  • Hypocretin/Orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: Relationship to the neuropeptide Y and agouti gene-related protein systems

    C. Broberger;L. De Lecea;J.G. Sutcliffe;T. Hökfelt

  • The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice

    Christian Broberger;Jeanette Johansen;Carolina Johansson;Martin Schalling

  • Primary sensory neurons of the rat showing calcitonin gene-related peptide immunoreactivity and their relation to substance P-, somatostatin-, galanin-, vasoactive intestinal polypeptide- and cholecystokinin-immunoreactive ganglion cells.

    G. Ju;Tomas Hökfelt;E. Brodin;J. Fahrenkrug

  • Immunohistochemical evidence of substance P-like immunoreactivity in some 5-hydroxytryptamine-containing neurons in the rat central nervous system.

    T. Hökfelt;T. Hökfelt;Å. Ljungdahl;Å. Ljungdahl;H. Steinbusch;H. Steinbusch;A. Verhofstad;A. Verhofstad

  • Differential co-existence of neuropeptide Y (NPY)-like immunoreactivity with catecholamines in the central nervous system of the rat.

    B.J. Everitt;T. Hökfelt;L. Terenius;K. Tatemoto

  • High levels of neuropeptide Y in peripheral noradrenergic neurons in various mammals including man.

    J.M. Lundberg;L. Terenius;T. Hökfelt;M. Goldstein

  • Messenger plasticity in primary sensory neurons following axotomy and its functional implications

    T. Hökfelt;X. Zhang;Z. Wiesenfeld-Hallin

  • Potent and nontoxic antisense oligonucleotides containing locked nucleic acids

    Claes R Wahlestedt;Peter Salmi;Liam Good;Johanna Kela

  • Neuropeptides in perspective: The last ten years

    Tomas Hökfelt

  • Immunohistochemical studies using antibodies to leucine-enkephalin: Initial observations on the nervous system of the rat

    R. Elde;T. Hökfelt;O. Johansson;L. Terenius

  • Co-existence of substance P and calcitonin gene-related peptide-like immunoreactivities in sensory nerves in relation to cardiovascular and bronchoconstrictor effects of capsaicin

    Jan M. Lundberg;Anders Franco-Cereceda;Xiaoying Hua;Tomas Hökfelt

  • Peptidergic neurones

    Unknown

Frequent Co-Authors

Kjell Fuxe
Kjell Fuxe Karolinska Institute
Menek Goldstein
Menek Goldstein New York University
Jan M. Lundberg
Jan M. Lundberg Karolinska Institute
Lars Terenius
Lars Terenius Karolinska Institute
Tibor Harkany
Tibor Harkany Medical University of Vienna
Tamas Bartfai
Tamas Bartfai Stockholm University
Robert Elde
Robert Elde University of Minnesota
Martin Schalling
Martin Schalling Karolinska Institute
Zsuzsanna Wiesenfeld-Hallin
Zsuzsanna Wiesenfeld-Hallin Karolinska Institute
Marcelo J. Villar
Marcelo J. Villar Austral University

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