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Ingolf Cascorbi

Ingolf Cascorbi

D-Index & Metrics

Medicine

D-Index
87
Citations
26140
World Ranking
13708
National Ranking
730

Overview

Ingolf Cascorbi is affiliated with Kiel University in Germany and has contributed extensively to the fields of Medicine, Biochemistry, Genetics, and Molecular Biology. Their research spans multiple subfields, including Molecular Biology, Pharmacology, Hematology, Cancer Research, and Genetics, reflecting a broad engagement with biomedical sciences.

Their recent publications include work on topics such as pharmacovigilance-based drug repurposing, pharmacogenomics, and drug transporter polymorphisms. Notable papers authored or co-authored by them are:

  • Pharmacovigilance-based drug repurposing: The search for inverse signals via OpenVigil identifies putative drugs against viral respiratory infections (2021, British Journal of Clinical Pharmacology)
  • Dihydropyrimidine Dehydrogenase Testing prior to Treatment with 5-Fluorouracil, Capecitabine, and Tegafur: A Consensus Paper (2020, Oncology Research and Treatment)
  • ABCB1, ABCG2, ABCC1, ABCC2, and ABCC3 drug transporter polymorphisms and their impact on drug bioavailability: what is our current understanding? (2021, Expert Opinion on Drug Metabolism & Toxicology)
  • Pharmacogenomics in practice: a review and implementation guide (2023, Frontiers in Pharmacology)
  • Meta-analysis on outcome-worsening comorbidities of COVID-19 and related potential drug-drug interactions (2020, Pharmacological Research)

Frequent co-authors collaborating with Ingolf Cascorbi include:

  • Meike Kaehler
  • Inga Nagel
  • Henrike Bruckmueller
  • Henrik Oster
  • Ruwen Böhm

The scientist has published numerous papers in several journals and venues, among which the most frequent are:

  • Clinical Pharmacology & Therapeutics (8 publications)
  • Frontiers in Pharmacology (4 publications)
  • eLife (3 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (3 publications)
  • Expert Opinion on Drug Metabolism & Toxicology (2 publications)

Ingolf Cascorbi's research has addressed several main topics, such as:

  • Chronic Myeloid Leukemia Treatments
  • MicroRNA in disease regulation
  • Drug Transport and Resistance Mechanisms
  • Pharmacogenetics and Drug Metabolism
  • Circular RNAs in diseases
  • Chronic Lymphocytic Leukemia Research
  • Circadian rhythm and melatonin

In addition to journal publications, Ingolf Cascorbi has contributed to book literature with a publication by Springer Science+Business Media titled Precision Medicine (2023).

Best Publications

  • Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

    S. Hoffmeyer;O. Burk;O. von Richter;H. P. Arnold

  • Metabolic gene polymorphism frequencies in control populations.

    S. Garte;L. Gaspari;A.K. Alexandrie;C. Ambrosone

  • Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects.

    Ingolf Cascorbi;Thomas Gerloff;Andreas Johne;Christian Meisel

  • Combined Analysis of Inherited Polymorphisms in Arylamine N-Acetyltransferase 2, Glutathione S-Transferases M1 and T1, Microsomal Epoxide Hydrolase, and Cytochrome P450 Enzymes as Modulators of Bladder Cancer Risk

    Jürgen Brockmöller;Ingolf Cascorbi;Reinhold Kerb;Ivar Roots

  • A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility.

    Ingolf Cascorbi;Jürgen Brockmöller;Ivar Roots

  • Arylamine N-acetyltransferase (NAT2) mutations and their allelic linkage in unrelated Caucasian individuals: correlation with phenotypic activity.

    I Cascorbi;N Drakoulis;J Brockmöller;A Maurer

  • Role of pharmacogenetics of ATP-binding cassette transporters in the pharmacokinetics of drugs.

    Ingolf Cascorbi

  • Deposition of Alzheimer's β-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans

    Silke Vogelgesang;Ingolf Cascorbi;Eike Schroeder;Jens Pahnke

  • Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis

    Matthias Schwab;Elke Schaeffeler;Claudia Marx;Martin F. Fromm

  • Modulation of steady-state kinetics of digoxin by haplotypes of the P-glycoprotein MDR1 gene.

    Andreas Johne;Karla Köpke;Thomas Gerloff;Ingrid Mai

  • Polymorphisms of drug-metabolizing enzymes CYP2C9, CYP2C19, CYP2D6, CYP1A1, NAT2 and of P-glycoprotein in a Russian population

    Elena A. Gaikovitch;Ingolf Cascorbi;Przemyslaw M. Mrozikiewicz;Jürgen Brockmöller

  • Mental and physical distress is modulated by a polymorphism in the 5-HT transporter gene interacting with social stressors and chronic disease burden.

    H J Grabe;M Lange;B Wolff;H Völzke

  • CYP1A1 and GSTM1 genetic polymorphisms and lung cancer risk in Caucasian non-smokers: a pooled analysis.

    Rayjean J. Hung;Paolo Boffetta;Jürgen Brockmöller;Dorota Butkiewicz

  • MDR1-P-Glycoprotein (ABCB1) Mediates Transport of Alzheimer’s Amyloid-β Peptides—Implications for the Mechanisms of Aβ Clearance at the Blood–Brain Barrier

    Diana Kuhnke;Gabriele Jedlitschky;Markus Grube;Markus Krohn

  • Functional Gene Variants of CYP3A4

    A N Werk;I Cascorbi

  • Pharmacogenetics of cytochrome P4502D6: genetic background and clinical implication

    I Cascorbi

  • The effects of the human MDR1 genotype on the expression of duodenal P-glycoprotein and disposition of the probe drug talinolol

    Werner Siegmund;Karen Ludwig;Thomas Giessmann;Peter Dazert

  • Modulation of benzo[a]pyrene diolepoxide–DNA adduct levels in human white blood cells by CYP1A1, GSTM1 and GSTT1 polymorphism

    Margarita Rojas;Ingolf Cascorbi;Kroum Alexandrov;Erik Kriek

  • Meta- and pooled analyses of GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes and risk of head and neck cancer

    Mia Hashibe;Paul Brennan;Richard C. Strange;Rajani Bhisey

  • P-glycoprotein: tissue distribution, substrates, and functional consequences of genetic variations

    Ingolf Cascorbi

Frequent Co-Authors

Ivar Roots
Ivar Roots Charité - University Medicine Berlin
Jürgen Brockmöller
Jürgen Brockmöller University of Göttingen
Heyo K. Kroemer
Heyo K. Kroemer University of Göttingen
Ann K. Daly
Ann K. Daly Newcastle University
Matthias Schwab
Matthias Schwab University of Tübingen
Thomas Herdegen
Thomas Herdegen Kiel University
Ulrich Brinkmann
Ulrich Brinkmann Roche (Switzerland)
Angela Risch
Angela Risch University of Salzburg
Stephanie J. London
Stephanie J. London National Institutes of Health

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