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Jürgen Brockmöller

Jürgen Brockmöller

D-Index & Metrics

Medicine

D-Index
98
Citations
37328
World Ranking
8893
National Ranking
498

Overview

Jürgen Brockmöller is affiliated with the University of Göttingen in Germany. Their research spans multiple fields, primarily focusing on Medicine and Biochemistry, Genetics, and Molecular Biology.

The scientist has contributed extensively to various topics, including:

  • Drug Transport and Resistance Mechanisms
  • Pharmacological Effects and Toxicity Studies
  • Amino Acid Enzymes and Metabolism
  • Pharmacogenetics and Drug Metabolism
  • Metabolism and Genetic Disorders
  • Transcranial Magnetic Stimulation Studies
  • DNA and Nucleic Acid Chemistry

Jürgen Brockmöller's research has been published frequently in notable scientific venues. The most common publication venues include:

  • Clinical Neurophysiology
  • Journal of Medicinal Chemistry
  • Frontiers in Pharmacology
  • Biochemical Pharmacology
  • International Journal of Molecular Sciences

Recent publications by Brockmöller include:

  • "Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines," 2020, Clinical Neurophysiology
  • "CYP2B6 Functional Variability in Drug Metabolism and Exposure Across Populations-Implication for Drug Safety, Dosing, and Individualized Therapy," 2021, Frontiers in Genetics
  • "Differences in Metformin and Thiamine Uptake between Human and Mouse Organic Cation Transporter 1: Structural Determinants and Potential Consequences for Intrahepatic Concentrations," 2020, Drug Metabolism and Disposition
  • "Identification of Novel High-Affinity Substrates of OCT1 Using Machine Learning-Guided Virtual Screening and Experimental Validation," 2021, Journal of Medicinal Chemistry
  • "The mystery of the human proton-organic cation antiporter: One transport protein or many?," 2022, Pharmacology & Therapeutics

The scientist frequently collaborates with colleagues including Ole Jensen, Lukas Gebauer, Christof Dücker, Mladen V. Tzvetkov, and Muhammad Rafehi. The counts of publications coauthored with these individuals range from 7 to 18.

Jürgen Brockmöller's work covers a range of subfields in study, prominently:

  • Oncology
  • Pharmacology
  • Molecular Biology
  • Pediatrics, Perinatology and Child Health
  • Biochemistry

Best Publications

  • Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

    S. Hoffmeyer;O. Burk;O. von Richter;H. P. Arnold

  • Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines

    Simone Rossi;Andrea Antal;Sven Bestmann;Marom Bikson

  • Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences.

    C Sachse;J Brockmöller;S Bauer;I Roots

  • Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines

    A. Antal;Ivan Alekseichuk;M. Bikson;J. Brockmöller

  • Functional significance of a C-->A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine

    Christoph Sachse;Jürgen Brockmöller;Steffen Bauer;Ivar Roots

  • Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response

    Kirchheiner J;Nickchen K;Bauer M;Wong Ml

  • The genetic determinants of the CYP3A5 polymorphism

    Elisabeth Hustert;Michael Haberl;Oliver Burk;Renzo Wolbold

  • Clinical consequences of cytochrome P450 2C9 polymorphisms.

    Julia Kirchheiner;Jürgen Brockmöller

  • Nomenclature for human CYP2D6 alleles.

    A K Daly;J Brockmoller;F Broly;M Eichelbaum

  • CYP2D6 and CYP2C19 genotype-based dose recommendations for antidepressants: a first step towards subpopulation-specific dosages.

    J Kirchheiner;K Brosen;Marja-Liisa Dahl;LF Gram

  • NAD(P)H Oxidase and Multidrug Resistance Protein Genetic Polymorphisms Are Associated With Doxorubicin-Induced Cardiotoxicity

    Leszek Wojnowski;Bettina Kulle;Markus Schirmer;Gregor Schlüter

  • Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication.

    J Kirchheiner;H Schmidt;M Tzvetkov;J-T H A Keulen

  • Combined Analysis of Inherited Polymorphisms in Arylamine N-Acetyltransferase 2, Glutathione S-Transferases M1 and T1, Microsomal Epoxide Hydrolase, and Cytochrome P450 Enzymes as Modulators of Bladder Cancer Risk

    Jürgen Brockmöller;Ingolf Cascorbi;Reinhold Kerb;Ivar Roots

  • A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility.

    Ingolf Cascorbi;Jürgen Brockmöller;Ivar Roots

  • Arylamine N-acetyltransferase (NAT2) mutations and their allelic linkage in unrelated Caucasian individuals: correlation with phenotypic activity.

    I Cascorbi;N Drakoulis;J Brockmöller;A Maurer

  • Interindividual variability and tissue-specificity in the expression of cytochrome P450 3A mRNA.

    Ina Koch;Regina Weil;Renzo Wolbold;Jürgen Brockmöller

  • Modulation of steady-state kinetics of digoxin by haplotypes of the P-glycoprotein MDR1 gene.

    Andreas Johne;Karla Köpke;Thomas Gerloff;Ingrid Mai

  • Polymorphisms of drug-metabolizing enzymes CYP2C9, CYP2C19, CYP2D6, CYP1A1, NAT2 and of P-glycoprotein in a Russian population

    Elena A. Gaikovitch;Ingolf Cascorbi;Przemyslaw M. Mrozikiewicz;Jürgen Brockmöller

  • The Effects of Genetic Polymorphisms in the Organic Cation Transporters OCT1, OCT2, and OCT3 on the Renal Clearance of Metformin

    V. Mladen Tzvetkov;V. Stefan Vormfelde;Daniela Balen;Ingolf Meineke

  • Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk

    Simone Benhamou;Won Jin Lee;Anna Karin Alexandrie;Paolo Boffetta

Frequent Co-Authors

Ivar Roots
Ivar Roots Charité - University Medicine Berlin
Ingolf Cascorbi
Ingolf Cascorbi Kiel University
Paolo Boffetta
Paolo Boffetta Stony Brook Medicine
Ann K. Daly
Ann K. Daly Newcastle University
Ulrich M. Zanger
Ulrich M. Zanger Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
Walter Paulus
Walter Paulus University of Göttingen
Stephanie J. London
Stephanie J. London National Institutes of Health
Paolo Vineis
Paolo Vineis Imperial College London
Peter Nürnberg
Peter Nürnberg University of Cologne
Magnus Ingelman-Sundberg
Magnus Ingelman-Sundberg Karolinska Institute

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