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Medicine

D-Index
81
Citations
25256
World Ranking
16588
National Ranking
867

Overview

Martin F. Fromm is affiliated with the University of Erlangen-Nuremberg in Germany and has an extensive publication record in the field of medicine, with a strong emphasis on pharmaceutical sciences and clinical pharmacology. Their research is primarily situated within several specialized subfields including pediatrics, perinatology and child health, molecular biology, oncology, geriatrics and gerontology, and pharmacology. The body of their work spans over 108 publications in medicine, reflecting a multidisciplinary approach.

The research topics covered by Martin F. Fromm focus on pharmaceutical practices and patient outcomes, drug transport and resistance mechanisms, pharmaceutical studies and practices, pharmacological effects and toxicity studies, pharmacovigilance and adverse drug reactions, amino acid enzymes and metabolism, and health systems, economic evaluations, and quality of life. This range shows a comprehensive engagement with both the clinical and molecular aspects of pharmacology and patient care.

The scientist has frequently published in journals such as Clinical Pharmacology & Therapeutics, British Journal of Clinical Pharmacology, Journal of Clinical Medicine, Clinical Chemistry and Laboratory Medicine (CCLM), and Deutsches Ärzteblatt international. The contributions to Clinical Pharmacology & Therapeutics alone total ten publications, highlighting this venue as a significant outlet for their work.

Among recent notable research papers are:

  • The Randomized AMBORA Trial: Impact of Pharmacological/Pharmaceutical Care on Medication Safety and Patient-Reported Outcomes During Treatment With New Oral Anticancer Agents (2021), published in Journal of Clinical Oncology
  • Validation of a Drug Transporter Probe Cocktail Using the Prototypical Inhibitors Rifampin, Probenecid, Verapamil, and Cimetidine (2020), published in Clinical Pharmacokinetics
  • Trimethylamine-N-oxide (TMAO) determined by LC-MS/MS: distribution and correlates in the population-based PopGen cohort (2020), published in Clinical Chemistry and Laboratory Medicine (CCLM)
  • Acod1-mediated inhibition of aerobic glycolysis suppresses osteoclast differentiation and attenuates bone erosion in arthritis (2024), published in Annals of the Rheumatic Diseases
  • Medication Errors During Treatment with New Oral Anticancer Agents: Consequences for Clinical Practice Based on the AMBORA Study (2021), published in Clinical Pharmacology & Therapeutics

Collaborative efforts form an important dimension of their work, with frequent co-authors including Renke Maas, Arne Gessner, Jörg König, Pauline Dürr, and Frank Dörje. The number of co-authored works ranges up to 22 articles with some colleagues, indicating ongoing and sustained scientific partnerships.

Best Publications

  • The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

    R. B. Kim;M. F. Fromm;C. Wandel;B. Leake

  • Pharmacokinetic interactions with rifampicin : clinical relevance.

    Mikko Niemi;Janne T. Backman;Martin F. Fromm;Pertti J. Neuvonen

  • OATP and P-Glycoprotein Transporters Mediate the Cellular Uptake and Excretion of Fexofenadine

    Mirjana Cvetkovic;Brenda Leake;Martin F. Fromm;Grant R. Wilkinson

  • Importance of P-glycoprotein at blood-tissue barriers.

    Martin F. Fromm

  • Piperine, a Major Constituent of Black Pepper, Inhibits Human P-glycoprotein and CYP3A4

    Rajinder K. Bhardwaj;Hartmut Glaeser;Laurent Becquemont;Ulrich Klotz

  • Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.

    R. B. Kim;C. Wandel;B. Leake;M. Cvetkovic

  • Transporters and Drug-Drug Interactions: Important Determinants of Drug Disposition and Effects

    Jörg König;Fabian Müller;Martin F. Fromm

  • Cytochrome P450 2C19 681G>A Polymorphism and High On-Clopidogrel Platelet Reactivity Associated With Adverse 1-Year Clinical Outcome of Elective Percutaneous Coronary Intervention With Drug-Eluting or Bare-Metal Stents

    Dietmar Trenk;Willibald Hochholzer;Martin F. Fromm;Ligia-Emilia Chialda

  • Inhibition of P-Glycoprotein–Mediated Drug Transport A Unifying Mechanism to Explain the Interaction Between Digoxin and Quinidine

    M F Fromm;R B Kim;C M Stein;G R Wilkinson

  • High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1).

    Mikko Niemi;Elke Schaeffeler;Thomas Lang;Martin F Fromm

  • The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56+ natural killer cells.

    Monika Hitzl;Siegfried Drescher;Heiko Van Der Kuip;Elke Schäffeler

  • P-glycoprotein: a defense mechanism limiting oral bioavailability and CNS accumulation of drugs.

    Fromm Mf

  • ABCG2 polymorphism markedly affects the pharmacokinetics of atorvastatin and rosuvastatin.

    Jenni Keskitalo;O Zolk;Martin F Fromm;Kaisa Kurkinen

  • Pharmacogenomics of human OATP transporters

    Jörg König;Annick Seithel;Ulrike Gradhand;Martin F. Fromm

  • Genetic polymorphisms of the human MDR1 drug transporter

    Matthias Schwab;Michel Eichelbaum;Martin F Fromm

  • Impact of Cytochrome P450 2C19 Loss-of-Function Polymorphism and of Major Demographic Characteristics on Residual Platelet Function After Loading and Maintenance Treatment With Clopidogrel in Patients Undergoing Elective Coronary Stent Placement

    Willibald Hochholzer;Dietmar Trenk;Martin F. Fromm;Christian M. Valina

  • Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis

    Matthias Schwab;Elke Schaeffeler;Claudia Marx;Martin F. Fromm

  • Modulation of steady-state kinetics of digoxin by haplotypes of the P-glycoprotein MDR1 gene.

    Andreas Johne;Karla Köpke;Thomas Gerloff;Ingrid Mai

  • Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin

    M F Fromm;D Busse;H K Kroemer;M Eichelbaum

  • The effect of rifampin treatment on intestinal expression of human MRP transporters.

    Martin F. Fromm;Hans-Martin Kauffmann;Peter Fritz;Oliver Burk

Frequent Co-Authors

Michel Eichelbaum
Michel Eichelbaum University of Tübingen
Matthias Schwab
Matthias Schwab University of Tübingen
Ute Hofmann
Ute Hofmann University of Tübingen
Heyo K. Kroemer
Heyo K. Kroemer University of Göttingen
Richard B. Kim
Richard B. Kim University of Western Ontario
Mikko Niemi
Mikko Niemi University of Helsinki
Kay Brune
Kay Brune University of Erlangen-Nuremberg
Dan M. Roden
Dan M. Roden Vanderbilt University Medical Center
Grant R. Wilkinson
Grant R. Wilkinson Vanderbilt University
Heinrich Sticht
Heinrich Sticht University of Erlangen-Nuremberg

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