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Biology and Biochemistry

D-Index
57
Citations
10591
World Ranking
13943
National Ranking
987

Overview

Ute Hofmann is affiliated with the University of Tübingen in Germany. Their research primarily focuses on medicine and biochemistry, genetics, and molecular biology, with significant contributions across multiple subfields including molecular biology, pharmacology, oncology, epidemiology, and cancer research.

Their work explores a range of topics, including:

  • Drug Transport and Resistance Mechanisms
  • Liver Disease Diagnosis and Treatment
  • Pharmacogenetics and Drug Metabolism
  • Cancer, Hypoxia, and Metabolism
  • Metabolomics and Mass Spectrometry Studies
  • Drug-Induced Hepatotoxicity and Protection
  • Liver Disease and Transplantation

They have published extensively, with notable papers such as:

  • "Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity," 2022, Journal of Hepatology
  • "Polycyclic Aromatic Hydrocarbons Activate the Aryl Hydrocarbon Receptor and the Constitutive Androstane Receptor to Regulate Xenobiotic Metabolism in Human Liver Cells," 2020, International Journal of Molecular Sciences
  • "Severe metabolic alterations in liver cancer lead to ERK pathway activation and drug resistance," 2020, EBioMedicine
  • "Progesterone receptor membrane component 1 regulates lipid homeostasis and drives oncogenic signaling resulting in breast cancer progression," 2020, Breast Cancer Research
  • "Transcriptomic Cross-Species Analysis of Chronic Liver Disease Reveals Consistent Regulation Between Humans and Mice," 2021, Hepatology Communications

Their research has appeared frequently in the following venues:

  • Zeitschrift für Gastroenterologie
  • Journal of Hepatology
  • International Journal of Molecular Sciences
  • Frontiers in Pharmacology
  • Breast Cancer Research

Ute Hofmann has collaborated with several frequent co-authors including:

  • Matthias Schwab
  • Jan G. Hengstler
  • Ahmed Ghallab
  • Reham Hassan
  • Maiju Myllys

Their research integrates aspects of drug metabolism, liver disease mechanisms, and cancer biology, often employing molecular and pharmacological approaches to address complex biomedical questions. The intersection of hepatotoxicity, metabolism, and cancer resistance mechanisms forms a critical component of their scientific contributions.

Best Publications

  • Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver.

    Thomas Lang;Kathrin Klein;Joachim Fischer;Andreas K. Nüssler

  • Role of Genetic and Nongenetic Factors for Fluorouracil Treatment-Related Severe Toxicity: A Prospective Clinical Trial by the German 5-FU Toxicity Study Group

    Matthias Schwab;Ulrich M. Zanger;Claudia Marx;Elke Schaeffeler

  • NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity

    Takaya Moriyama;Takaya Moriyama;Rina Nishii;Rina Nishii;Virginia Perez-Andreu;Wenjian Yang

  • Gabapentin enhances the analgesic effect of morphine in healthy volunteers.

    Klaus Eckhardt;Susanne Ammon;Ute Hofmann;Anja Riebe

  • MDR1 gene polymorphisms and disposition of the P‐glycoprotein substrate fexofenadine

    Siegfried Drescher;Elke Schaeffeler;Monika Hitzl;Ute Hofmann

  • Antipyrine as a probe for human oxidative drug metabolism: Identification of the cytochrome P450 enzymes catalyzing 4‐hydroxyantipyrine, 3‐hydroxymethylantipyrine, and norantipyrine formation

    Georg Engel;Georg Engel;Ute Hofmann;Ute Hofmann;Hugo Heidemann;Hugo Heidemann;Jose Cosme;Jose Cosme

  • Cyclophosphamide pharmacokinetics and dose requirements in patients with renal insufficiency.

    Marion Haubitz;Frank Bohnenstengel;Reinhard Brunkhorst;Matthias Schwab

  • Fexofenadine pharmacokinetics are associated with a polymorphism of the SLCO1B1 gene (encoding OATP1B1).

    Mikko Niemi;Kari T. Kivistö;Ute Hofmann;Matthias Schwab

  • Proton pump inhibitors inhibit metformin uptake by organic cation transporters (OCTs)

    Anne T. Nies;Ute Hofmann;Ute Hofmann;Claudia Resch;Claudia Resch;Elke Schaeffeler;Elke Schaeffeler

  • Acute effects of pravastatin on cholesterol synthesis are associated with SLCO1B1 (encoding OATP1B1) haplotype *17.

    Mikko Niemi;Pertti J Neuvonen;Ute Hofmann;Janne T Backman

  • Pharmacokinetic modelling of morphine, morphine-3-glucuronide and morphine-6-glucuronide in plasma and cerebrospinal fluid of neurosurgical patients after short-term infusion of morphine.

    Ingolf Meineke;Stefan Freudenthaler;Stefan Freudenthaler;Ute Hofmann;Elke Schaeffeler

  • DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma

    Elke Schaeffeler;Claus Hellerbrand;Anne T Nies;Stefan Winter

  • UDP-Glucuronosyltransferase (UGT) Polymorphisms Affect Atorvastatin Lactonization In Vitro and In Vivo

    S Riedmaier;S Riedmaier;K Klein;K Klein;U Hofmann;U Hofmann;J E Keskitalo

  • Impact of the SLCO1B1 polymorphism on the pharmacokinetics and lipid-lowering efficacy of multiple-dose pravastatin

    Michael Igel;Katja A. Arnold;Mikko Niemi;Ute Hofmann

  • Profiling Induction of Cytochrome P450 Enzyme Activity by Statins Using a New Liquid Chromatography-Tandem Mass Spectrometry Cocktail Assay in Human Hepatocytes

    Diana M Feidt;Kathrin Klein;Ute Hofmann;Stephan Riedmaier

  • Loss of analgesic effect of morphine due to coadministration of rifampin

    Martin F Fromm;Klaus Eckhardt;Shuxia Li;Gerhard Schänzle

  • Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours.

    Zeribe C. Nwosu;Nadia Battello;Melanie Rothley;Melanie Rothley;Weronika Piorońska

  • 6-Thioguanosine Diphosphate and Triphosphate Levels in Red Blood Cells and Response to Azathioprine Therapy in Crohn’s Disease

    Markus F. Neurath;Ralf Kiesslich;Ute Teichgräber;Christine Fischer

  • A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation.

    Christoph Thiel;Christoph Thiel;Sebastian Schneckener;Markus Krauss;Markus Krauss;Ahmed Ghallab

  • Influence of age and cytochrome P450 2C9 genotype on the steady-state disposition of diclofenac and celecoxib.

    Stefanie S. Brenner;Charlotte Herrlinger;Karin Dilger;Thomas E. Mürdter

Frequent Co-Authors

Matthias Schwab
Matthias Schwab University of Tübingen
Michel Eichelbaum
Michel Eichelbaum University of Tübingen
Ulrich M. Zanger
Ulrich M. Zanger Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
Martin F. Fromm
Martin F. Fromm University of Erlangen-Nuremberg
Kathrin Klein
Kathrin Klein Robert Bosch (Germany)
Jan G. Hengstler
Jan G. Hengstler TU Dortmund University
Rolf Gebhardt
Rolf Gebhardt Leipzig University
Heyo K. Kroemer
Heyo K. Kroemer University of Göttingen
Markus F. Neurath
Markus F. Neurath University of Erlangen-Nuremberg
Ulrich Klotz
Ulrich Klotz Robert Bosch (Germany)

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