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Genetics
Germany
2024
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Genetics and Molecular Biology
Germany
2024

D-Index & Metrics

Genetics

D-Index
95
Citations
32480
World Ranking
902
National Ranking
75

Research.com Recognitions

  • 2024 - Research.com Genetics in Germany Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in Germany Leader Award
  • 2023 - Research.com Genetics in Germany Leader Award

Overview

Ulrich M. Zanger is affiliated with the Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology in Germany. Their research spans multiple fields including Medicine, Biochemistry, Genetics and Molecular Biology, and Pharmacology, Toxicology and Pharmaceutics.

The scientist's work primarily focuses on areas such as Pharmacogenetics and Drug Metabolism, Drug Transport and Resistance Mechanisms, Cancer, Lipids, and Metabolism, Estrogen and related hormone effects, Toxic Organic Pollutants Impact, Analytical Chemistry and Chromatography, and Cholesterol and Lipid Metabolism.

Frequent coauthors in their publications include:

  • Ute Hofmann
  • Kathrin Klein
  • Matthias Schwab
  • Hannah Asperger
  • Nadia Stamm

The scientist has contributed to research published in several venues, with multiple publications in:

  • Breast Cancer Research
  • International Journal of Molecular Sciences
  • Gut
  • Scientific Reports
  • Frontiers in Pharmacology

Recent papers authored or co-authored by Ulrich M. Zanger include:

  • Polycyclic Aromatic Hydrocarbons Activate the Aryl Hydrocarbon Receptor and the Constitutive Androstane Receptor to Regulate Xenobiotic Metabolism in Human Liver Cells, 2020, International Journal of Molecular Sciences
  • Progesterone receptor membrane component 1 regulates lipid homeostasis and drives oncogenic signaling resulting in breast cancer progression, 2020, Breast Cancer Research
  • TGF-β2 silencing to target biliary-derived liver diseases, 2020, Gut
  • Differential effects on human cytochromes P450 by CRISPR/Cas9-induced genetic knockout of cytochrome P450 reductase and cytochrome b5 in HepaRG cells, 2021, Scientific Reports
  • Effects of Diminished NADPH:cytochrome P450 Reductase in Human Hepatocytes on Lipid and Bile Acid Homeostasis, 2021, Frontiers in Pharmacology

Best Publications

  • Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

    Ulrich M. Zanger;Matthias Schwab;Matthias Schwab

  • Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry

    Ulrich M. Zanger;Sebastian Raimundo;Michel Eichelbaum

  • Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.

    F J Gonzalez;R C Skoda;S Kimura;M Umeno

  • The genetic determinants of the CYP3A5 polymorphism

    Elisabeth Hustert;Michael Haberl;Oliver Burk;Renzo Wolbold

  • Molecular mechanisms of genetic polymorphisms of drug metabolism.

    Urs A. Meyer;Ulrich M. Zanger

  • Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation

    Ulrich M. Zanger;Ulrich M. Zanger;Miia Turpeinen;Miia Turpeinen;Miia Turpeinen;Kathrin Klein;Kathrin Klein;Matthias Schwab;Matthias Schwab

  • Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver.

    Thomas Lang;Kathrin Klein;Joachim Fischer;Andreas K. Nüssler

  • Sex is a major determinant of CYP3A4 expression in human liver

    Renzo Wolbold;Kathrin Klein;Oliver Burk;Andreas K. Nüssler

  • Nomenclature for human CYP2D6 alleles.

    A K Daly;J Brockmoller;F Broly;M Eichelbaum

  • Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes.

    Werner Schroth;Lydia Antoniadou;Peter Fritz;Matthias Schwab

  • Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants

    Elke Schaeffeler;Christine Fischer;Dierk Brockmeier;Dorothee Wernet

  • Role of Genetic and Nongenetic Factors for Fluorouracil Treatment-Related Severe Toxicity: A Prospective Clinical Trial by the German 5-FU Toxicity Study Group

    Matthias Schwab;Ulrich M. Zanger;Claudia Marx;Elke Schaeffeler

  • Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver.

    Anne T. Nies;Hermann Koepsell;Stefan Winter;Stefan Winter;Oliver Burk

  • Interindividual variability and tissue-specificity in the expression of cytochrome P450 3A mRNA.

    Ina Koch;Regina Weil;Renzo Wolbold;Jürgen Brockmöller

  • Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis

    Matthias Schwab;Elke Schaeffeler;Claudia Marx;Martin F. Fromm

  • Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population

    Ernst-Ulrich Griese;Ulrich Zanger;Ulrich Brudermanns;Andrea Gaedigk

  • Clinical relevance of DPYD variants c.1679T>G, c.1236G>A/HapB3, and c.1601G>A as predictors of severe fluoropyrimidine-associated toxicity: a systematic review and meta-analysis of individual patient data

    Didier Meulendijks;Linda M Henricks;Gabe S Sonke;Maarten J Deenen

  • Frequency of C3435T polymorphism of MDR1 gene in African people

    Elke Schaeffeler;Michel Eichelbaum;Michel Eichelbaum;Ulrich Brinkmann;Anja Penger

  • Genetic variability of CYP2B6 in populations of African and Asian origin: allele frequencies, novel functional variants, and possible implications for anti-HIV therapy with efavirenz.

    Kathrin Klein;Thomas Lang;Tanja Saussele;Eduardo Barbosa-Sicard

  • Azathioprine therapy and adverse drug reactions in patients with inflammatory bowel disease: impact of thiopurine S-methyltransferase polymorphism

    Matthias Schwab;Elke Schäffeler;Claudia Marx;Christine Fischer

Frequent Co-Authors

Kathrin Klein
Kathrin Klein Robert Bosch (Germany)
Matthias Schwab
Matthias Schwab University of Tübingen
Michel Eichelbaum
Michel Eichelbaum University of Tübingen
Ute Hofmann
Ute Hofmann University of Tübingen
Thomas Lang
Thomas Lang University of California, San Francisco
Jürgen Brockmöller
Jürgen Brockmöller University of Göttingen
Andreas K. Nussler
Andreas K. Nussler University of Tübingen
Dieter Häussinger
Dieter Häussinger Heinrich Heine University Düsseldorf
Heyo K. Kroemer
Heyo K. Kroemer University of Göttingen
Martin F. Fromm
Martin F. Fromm University of Erlangen-Nuremberg

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