World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
73
Citations
17589
World Ranking
5989
National Ranking
2828

Medicine

D-Index
74
Citations
18024
World Ranking
19466
National Ranking
9691

Overview

J. Steven Leeder is affiliated with Children's Mercy Hospital in the United States. Their research spans multiple interdisciplinary fields with a primary focus on medicine and biochemistry, genetics, and molecular biology. Within these fields, they concentrate particularly on pharmacology, pediatrics, perinatology and child health, oncology, clinical biochemistry, and physiology.

The main areas of their research include pharmacogenetics and drug metabolism, drug transport and resistance mechanisms, metabolism and genetic disorders, pharmaceutical studies and practices, diet and metabolism studies, liver disease diagnosis and treatment, and lipoproteins and cardiovascular health.

Leeder has authored numerous papers, with recent publications including:

  • Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy, 2021, Clinical Pharmacology & Therapeutics
  • Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin Reuptake Inhibitor Antidepressants, 2023, Clinical Pharmacology & Therapeutics
  • Genomic answers for children: Dynamic analyses of >1000 pediatric rare disease genomes, 2022, Genetics in Medicine
  • Clinical Implications of Altered Drug Transporter Abundance/Function and PBPK Modeling in Specific Populations: An ITC Perspective, 2022, Clinical Pharmacology & Therapeutics
  • Recent advances in the ontogeny of drug disposition, 2021, British Journal of Clinical Pharmacology

Their collaborations include frequent co-authors such as Andrea Gaedigk, Vincent S. Staggs, Bhagwat Prasad, Robin E. Pearce, and Roger Gaedigk.

Leeder's publications are published primarily in the following venues:

  • Clinical Pharmacology & Therapeutics
  • Drug Metabolism and Disposition
  • Clinical and Translational Science
  • Drug Metabolism and Pharmacokinetics
  • UNC Libraries

Best Publications

  • Developmental Pharmacology — Drug Disposition, Action, and Therapy in Infants and Children

    Gregory L. Kearns;Susan M. Abdel-Rahman;Sarah W. Alander;Douglas L. Blowey

  • Cytochrome P450 3A: ontogeny and drug disposition.

    S N de Wildt;G L Kearns;J S Leeder;J N van den Anker

  • Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing

    K.A. Birdwell;B. Decker;J.M. Barbarino;J.F. Peterson

  • Prediction of CYP2D6 phenotype from genotype across world populations.

    Andrea Gaedigk;Andrea Gaedigk;Katrin Sangkuhl;Michelle Whirl-Carrillo;Teri Klein

  • Valproic acid pathway: pharmacokinetics and pharmacodynamics

    Yogita Ghodke-Puranik;Caroline F. Thorn;Jatinder K. Lamba;J. Steven Leeder

  • The Pharmacogene Variation (PharmVar) Consortium: Incorporation of the Human Cytochrome P450 (CYP) Allele Nomenclature Database.

    Andrea Gaedigk;Magnus Ingelman-Sundberg;Neil A. Miller;J. Steven Leeder

  • Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver

    Xia Yang;Bin Zhang;Cliona Molony;Eugene Chudin

  • Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy.

    Kristine R. Crews;Andrew A. Monte;Rachel Huddart;Kelly E. Caudle

  • Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans.

    Andrea Gaedigk;Andrea Gaedigk;L. DiAnne Bradford;L. DiAnne Bradford;Kenda A. Marcucci;Kenda A. Marcucci;J. Steven Leeder;J. Steven Leeder

  • PHARMACOGENETICS IN PEDIATRICS: Implications for Practice

    J. Steven Leeder;Gregory L. Kearns

  • Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data.

    Andrea Gaedigk;R. Gotschall;Nataŝa Forbes;Stephen Simon

  • Safety of codeine during breastfeeding Fatal morphine poisoning in the breastfed neonate of a mother prescribed codeine

    Parvaz Madadi;Gideon Koren;James Cairns;David Chitayat

  • Ontogeny of drug metabolizing enzymes in the neonate.

    Michael J. Blake;Lisa Castro;J. Steven Leeder;Gregory L. Kearns

  • Cytochrome P4502D6 (CYP2D6) gene locus heterogeneity: characterization of gene duplication events.

    A Gaedigk;L Ndjountché;K Divakaran;L Dianne Bradford

  • Combined phenotypic assessment of cytochrome P450 1A2, 2C9, 2C19, 2D6, and 3A, N‐acetyltransferase‐2, and xanthine oxidase activities with the “Cooperstown 5+1 cocktail”

    Siwaporn Chainuvati;Anne N. Nafziger;J. Steven Leeder;Andrea Gaedigk

  • Variability of CYP3A7 Expression in Human Fetal Liver

    J. Steven Leeder;Roger Gaedigk;Kenda A. Marcucci;Andrea Gaedigk

  • Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail".

    Daniel S. Streetman;Jeffrey F. Bleakley;Jooran S. Kim;Anne N. Nafziger

  • Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy

    Jacob T. Brown;Jeffrey R. Bishop;Katrin Sangkuhl;Erika L. Nurmi

  • Pathways of Carbamazepine Bioactivation in Vitro I. Characterization of Human Cytochromes P450 Responsible for the Formation of 2- and 3-Hydroxylated Metabolites

    Robin E. Pearce;Gangadhara R. Vakkalagadda;J. Steven Leeder

  • Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors

    J. Kevin Hicks;Jeffrey R. Bishop;Katrin Sangkuhl;Daniel J Müller

Frequent Co-Authors

Andrea Gaedigk
Andrea Gaedigk University of Missouri–Kansas City
Gregory L. Kearns
Gregory L. Kearns University of Arkansas for Medical Sciences
Teri E. Klein
Teri E. Klein Stanford University
Angela D. M. Kashuba
Angela D. M. Kashuba University of North Carolina at Chapel Hill
Abdul Basit
Abdul Basit University College London
Gideon Koren
Gideon Koren Brown University
Julie A. Johnson
Julie A. Johnson University of Florida
Erin G. Schuetz
Erin G. Schuetz St. Jude Children's Research Hospital
Kelan G. Tantisira
Kelan G. Tantisira University of California, San Diego
Peter K. Rogan
Peter K. Rogan University of Western Ontario

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

For students interested in Biology and Biochemistry, several online degree options offer flexible pathways to rewarding careers. Healthcare and life sciences industries are evolving quickly, increasing the demand for professionals with diverse scientific backgrounds.

If you're considering nursing, an asn program online can provide essential clinical knowledge and prepare you for entry-level healthcare roles. Those keen on nutrition and wellness might explore the best online nutrition programs to develop skills in dietetics or health coaching.

For leadership positions, pursuing a master’s in healthcare administration from top online mha programs that are cahme accredited opens doors to supervisory roles in hospitals and labs. Already a nurse or clinician? Consider advancing with a dnp program without clinical hours to move into education or administration.

These programs can complement your biology or biochemistry knowledge, expand career options, and offer the flexibility to study while working or managing other commitments.

Best Scientists Citing J. Steven Leeder

Trending Scientists

Recently Published Articles