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Biology and Biochemistry

D-Index
72
Citations
19726
World Ranking
6269
National Ranking
2944

Overview

Angela D. M. Kashuba is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research spans a broad range of topics within medicine, focusing extensively on infectious diseases, virology, and epidemiology, with additional work in emergency medicine and pediatrics, perinatology, and child health.

The scientist's work primarily addresses HIV/AIDS drug development and treatment, covering HIV research and interventions as well as associated health complications and treatment options. Their interests also include pharmacological effects, toxicity studies, cytomegalovirus and herpesvirus research, and reproductive tract infections.

Among their recent publications are:

  • The Lymph Node Reservoir: Physiology, HIV Infection, and Antiretroviral Therapy, 2021, Clinical Pharmacology & Therapeutics
  • Ending the evidence gap for pregnancy, HIV and co-infections: ethics guidance from the PHASES project, 2021, Journal of the International AIDS Society
  • Antiretroviral Therapy Concentrations Differ in Gut vs. Lymph Node Tissues and Are Associated With HIV Viral Transcription by a Novel RT-ddPCR Assay, 2020, JAIDS Journal of Acquired Immune Deficiency Syndromes
  • A mechanism-based pharmacokinetic model of remdesivir leveraging interspecies scaling to simulate COVID-19 treatment in humans, 2020, CPT Pharmacometrics & Systems Pharmacology
  • Ultra-long-acting in-situ forming implants with cabotegravir protect female macaques against rectal SHIV infection, 2023, Nature Communications

Frequent coauthors associated with Angela D. M. Kashuba include:

  • Mackenzie L. Cottrell
  • Craig Sykes
  • Amanda P. Schauer
  • Elias P. Rosen
  • Kristine B. Patterson

Their scientific contributions have been published in venues such as UNC Libraries, Antimicrobial Agents and Chemotherapy, bioRxiv (Cold Spring Harbor Laboratory), Clinical Pharmacology & Therapeutics, and Journal of Controlled Release.

Best Publications

  • Preexposure Prophylaxis for HIV Infection among African Women

    Lut Van Damme;Amy Corneli;Khatija Ahmed;Johan Lombaard

  • Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

    N. M. Archin;A. L. Liberty;A. D. Kashuba;S. K. Choudhary

  • Evaluation of the genetic component of variability in CYP3A4 activity: a repeated drug administration method.

    Vural Özdemir;Werner Kalow;Bing Kou Tang;Andrew D. Paterson

  • Optimizing Aminoglycoside Therapy for Nosocomial Pneumonia Caused by Gram-Negative Bacteria

    Angela D. M. Kashuba;Anne N. Nafziger;George L. Drusano;Joseph S. Bertino

  • An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients.

    Celsa A. Spina;Celsa A. Spina;Jenny Anderson;Nancie M. Archin;Alberto Bosque

  • Penetration of Tenofovir and Emtricitabine in Mucosal Tissues: Implications for Prevention of HIV-1 Transmission

    Kristine B. Patterson;Heather A. Prince;Eric Kraft;Amanda J. Jenkins

  • Narrative review: antiretroviral therapy to prevent the sexual transmission of HIV-1.

    Myron S Cohen;Angela D M Kashuba;Sally Blower

  • A Translational Pharmacology Approach to Predicting Outcomes of Preexposure Prophylaxis Against HIV in Men and Women Using Tenofovir Disoproxil Fumarate With or Without Emtricitabine.

    MacKenzie L. Cottrell;Kuo-Hsiung Yang;Heather M.A. Prince;Craig Sykes

  • Clinical pharmacokinetic, pharmacodynamic and drug-interaction profile of the integrase inhibitor dolutegravir.

    Mackenzie L. Cottrell;Tanja Hadzic;Angela D. M. Kashuba

  • Antiretroviral treatment of HIV-1 prevents transmission of HIV-1: where do we go from here?

    Myron S Cohen;M. Kumi Smith;Kathryn Elizabeth Muessig;Timothy B. Hallett

  • HIV-1 Expression Within Resting CD4+ T Cells After Multiple Doses of Vorinostat

    Nancy M. Archin;Rosalie Bateson;Manoj K. Tripathy;Amanda M. Crooks

  • Drug concentrations after topical and oral antiretroviral pre-exposure prophylaxis: implications for HIV prevention in women

    Salim Safurdeen. Abdool Karim;Angela D. M. Kashuba;Lise. Werner;Quarraisha. Abdool Karim;Quarraisha. Abdool Karim

  • Lopinavir/ritonavir induces the hepatic activity of cytochrome P450 enzymes CYP2C9, CYP2C19, and CYP1A2 but inhibits the hepatic and intestinal activity of CYP3A as measured by a phenotyping drug cocktail in healthy volunteers

    Rosa F. Yeh;Vincent E. Gaver;Kristine B. Patterson;Naser L. Rezk

  • Interval dosing with the HDAC inhibitor vorinostat effectively reverses HIV latency

    Nancie M. Archin;Jennifer L. Kirchherr;Julia A.M. Sung;Genevieve Clutton

  • Antiretroviral drug exposure in the female genital tract: implications for oral pre- and post-exposure prophylaxis.

    Julie B Dumond;Rosa F Yeh;Kristine B Patterson;Amanda H Corbett

  • Bottlenecks in HIV-1 transmission: insights from the study of founder viruses

    Sarah Beth Joseph;Ronald I Swanstrom;Angela D Kashuba;Myron S Cohen

  • Simultaneous determination of 17 antiretroviral drugs in human plasma for quantitative analysis with liquid chromatography-tandem mass spectrometry.

    Byung Hwa Jung;Byung Hwa Jung;Naser L. Rezk;Arlene S. Bridges;Amanda H. Corbett

  • Antiretroviral-Drug Concentrations in Semen: Implications for Sexual Transmission of Human Immunodeficiency Virus Type 1

    Angela D. M. Kashuba;John R. Dyer;Linda M. Kramer;Ralph H. Raasch

  • Updated guideline to perform therapeutic drug monitoring for antiretroviral agents.

    C.J.L. la Porte;D. Back;T. Blaschke;C.A.B. Boucher

  • Physiological Changes During the Menstrual Cycle and Their Effects on the Pharmacokinetics and Pharmacodynamics of Drugs

    Angela D. M. Kashuba;Anne N. Nafziger

Frequent Co-Authors

Myron S. Cohen
Myron S. Cohen University of North Carolina at Chapel Hill
Joseph J. Eron
Joseph J. Eron University of North Carolina at Chapel Hill
Susan A. Fiscus
Susan A. Fiscus University of North Carolina at Chapel Hill
Salim S. Abdool Karim
Salim S. Abdool Karim Centre for the AIDS Programme of Research in South Africa
Jacob D. Estes
Jacob D. Estes Oregon Health & Science University
Quarraisha Abdool Karim
Quarraisha Abdool Karim Centre for the AIDS Programme of Research in South Africa
Gregory L. Kearns
Gregory L. Kearns University of Arkansas for Medical Sciences
Nicholas J. Shaheen
Nicholas J. Shaheen University of North Carolina at Chapel Hill
David M. Margolis
David M. Margolis University of North Carolina at Chapel Hill
Paul A. Luciw
Paul A. Luciw University of California, Davis

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