World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
82
Citations
26003
World Ranking
1498
National Ranking
754

Overview

Jacob D. Estes is affiliated with Oregon Health & Science University in the United States. Their research spans multiple areas within medicine, with a strong emphasis on immunology and microbiology. The scientist's work includes significant contributions in virology, infectious diseases, immunology, epidemiology, and emergency medicine.

Estes's research topics cover a range of issues related to HIV and related diseases, including:

  • HIV Research and Treatment
  • Immune Cell Function and Interaction
  • HIV/AIDS Research and Interventions
  • Cytomegalovirus and herpesvirus research
  • HIV-related health complications and treatments
  • COVID-19 Clinical Research Studies
  • HIV/AIDS drug development and treatment

The scientist has authored numerous papers, some of the more recent ones include:

  • "SARS-CoV-2 infection protects against rechallenge in rhesus macaques" (2020), published in Science
  • "Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters" (2020), published in Nature Medicine
  • "Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques" (2020), published in Cell
  • "Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques" (2020), published in Cell
  • "Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells" (2020), published in Nature

Frequent collaborators in their research include Kathleen Busman-Sahay, Michael Nekorchuk, Mirko Paiardini, Claire Deléage, and Chi Ngai Chan.

Estes has contributed to various academic venues, with multiple publications in:

  • PLoS Pathogens
  • UNC Libraries
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Medicine
  • The Journal of Immunology

Best Publications

  • Peak SIV replication in resting memory CD4 + T cells depletes gut lamina propria CD4 + T cells

    Qingsheng Li;Lijie Duan;Jacob D. Estes;Zhong-Min Ma

  • An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist

    Ivona Aksentijevich;Seth L. Masters;Polly J. Ferguson;Paul Dancey

  • Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease

    Christopher B. Forsyth;Kathleen M. Shannon;Jeffrey H. Kordower;Robin M. Voigt

  • SARS-CoV-2 infection protects against rechallenge in rhesus macaques.

    Abishek Chandrashekar;Jinyan Liu;Amanda J. Martinot;Amanda J. Martinot;Katherine McMahan

  • Glycerol monolaurate prevents mucosal SIV transmission

    Qingsheng Li;Jacob D. Estes;Patrick M. Schlievert;Lijie Duan

  • Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1

    Michael W Melkus;Jacob D Estes;Angela Padgett-Thomas;Joel Gatlin

  • Immune clearance of highly pathogenic SIV infection

    Scott G. Hansen;Michael Piatak;Abigail B. Ventura;Colette M. Hughes

  • Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections

    Jacob D. Estes;Levelle D. Harris;Nichole R. Klatt;Brian Tabb

  • B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers.

    Yoshinori Fukazawa;Richard Lum;Afam A Okoye;Haesun Park

  • Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression

    Netanya G. Sandler;Netanya G. Sandler;Steven E. Bosinger;Jacob D. Estes;Richard T R Zhu

  • CXCR5 + follicular cytotoxic T cells control viral infection in B cell follicles

    Yew Ann Leong;Yaping Chen;Hong Sheng Ong;Di Wu

  • Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz

    Brandon F. Keele;Brandon F. Keele;James Holland Jones;Karen A. Terio;Jacob D. Estes

  • Inadequate T follicular cell help impairs B cell immunity during HIV infection

    Rafael A. Cubas;Joseph C. Mudd;Anne Laure Savoye;Matthieu Perreau

  • Defining total-body AIDS-virus burden with implications for curative strategies

    Jacob D. Estes;Cissy Kityo;Francis Ssali;Louise Swainson

  • Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice

    Paul W. Denton;Jacob D. Estes;Zhifeng Sun;Florence A. Othieno

  • Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections

    Ming Zeng;Anthony J. Smith;Stephen W. Wietgrefe;Peter J. Southern

  • Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters.

    Lisa H. Tostanoski;Frank Wegmann;Amanda J. Martinot;Amanda J. Martinot;Carolin Loos;Carolin Loos

  • Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption

    Meghan K Rothenberger;Brandon F. Keele;Stephen W Wietgrefe;Courtney V. Fletcher

  • Intrarectal transmission, systemic infection, and CD4+ T cell depletion in humanized mice infected with HIV-1

    Zhifeng Sun;Paul W. Denton;Jacob D. Estes;Florence A. Othieno

  • Zika viral dynamics and shedding in rhesus and cynomolgus macaques.

    Christa E. Osuna;So Yon Lim;Claire Deleage;Bryan D. Griffin

  • Downregulation of Robust Acute Type I Interferon Responses Distinguishes Nonpathogenic Simian Immunodeficiency Virus (SIV) Infection of Natural Hosts from Pathogenic SIV Infection of Rhesus Macaques

    Levelle D. Harris;Brian Tabb;Donald L. Sodora;Mirko Paiardini

  • Premature Induction of an Immunosuppressive Regulatory T Cell Response during Acute Simian Immunodeficiency Virus Infection

    Jacob D. Estes;Qingsheng Li;Matthew R. Reynolds;Stephen W Wietgrefe

Frequent Co-Authors

Guido Silvestri
Guido Silvestri Emory University
Mirko Paiardini
Mirko Paiardini Emory University
Brandon F. Keele
Brandon F. Keele National Institutes of Health
Jason M. Brenchley
Jason M. Brenchley National Institute of Allergy and Infectious Diseases
Ashley T. Haase
Ashley T. Haase University of Minnesota
Daniel C. Douek
Daniel C. Douek National Institute of Allergy and Infectious Diseases
Timothy W. Schacker
Timothy W. Schacker University of Minnesota
Jeffrey D. Lifson
Jeffrey D. Lifson Leidos (United States)
Louis J. Picker
Louis J. Picker Oregon Health & Science University
Cavan S. Reilly
Cavan S. Reilly University of Minnesota

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