World's Best Scientists 2026 revealed!

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Immunology

D-Index
86
Citations
27881
World Ranking
1261
National Ranking
658

Medicine

D-Index
86
Citations
27881
World Ranking
14110
National Ranking
7157

Overview

Jeffrey D. Lifson is affiliated with Leidos in the United States and has contributed extensively to the fields of immunology, microbiology, and medicine. The scientist's primary research interests focus on HIV research and treatment, immune cell function and interaction, and herpesvirus infections. Lifson's work notably spans subfields such as virology, immunology, epidemiology, infectious diseases, and genetics.

The scientist's published papers cover a range of topics central to HIV/AIDS and immune system interactions. Notable recent papers include:

  • Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo (2020, Nature)
  • Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells (2020, Nature)
  • CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption (2020, Nature Medicine)
  • Pembrolizumab induces HIV latency reversal in people living with HIV and cancer on antiretroviral therapy (2022, Science Translational Medicine)
  • Fc-mediated effector function contributes to the in vivo antiviral effect of an HIV neutralizing antibody (2020, Proceedings of the National Academy of Sciences)

Frequent coauthors include Brandon F. Keele, Christine M. Fennessey, Louis J. Picker, Guido Silvestri, and Rebecca Shoemaker. Collaborations with these researchers have contributed to a significant body of work in the field of HIV and immunology.

Lifson has published numerous articles in various scientific venues. The primary venues for publication include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • PLoS Pathogens
  • Nature
  • UNC Libraries
  • Journal of Virology

The scientist's main topics of research focus on:

  • HIV Research and Treatment
  • Immune Cell Function and Interaction
  • Cytomegalovirus and herpesvirus research
  • Herpesvirus Infections and Treatments
  • HIV/AIDS Research and Interventions
  • HIV/AIDS drug development and treatment
  • T-cell and B-cell Immunology

Jeffrey D. Lifson's work integrates detailed investigations into viral latency and immune response mechanisms, frequently addressing questions central to viral reactivation and immune checkpoint modulation. This includes research into immune therapies and neutralizing antibodies relevant to managing HIV and other viral infections.

Best Publications

  • Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

    Scott G. Hansen;Julia C. Ford;Matthew S. Lewis;Abigail B. Ventura

  • Distribution and three-dimensional structure of AIDS virus envelope spikes

    Ping Zhu;Jun Liu;Julian Bess;Elena Chertova

  • Glycerol monolaurate prevents mucosal SIV transmission

    Qingsheng Li;Jacob D. Estes;Patrick M. Schlievert;Lijie Duan

  • Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge

    Scott G Hansen;Cassandra Vieville;Nathan Whizin;Lia Coyne-Johnson

  • Immune clearance of highly pathogenic SIV infection

    Scott G. Hansen;Michael Piatak;Abigail B. Ventura;Colette M. Hughes

  • Sex differences in the Toll-like receptor–mediated response of plasmacytoid dendritic cells to HIV-1

    Angela Meier;J Judy Chang;Ellen S Chan;Richard B Pollard

  • Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections

    Jacob D. Estes;Levelle D. Harris;Nichole R. Klatt;Brian Tabb

  • Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia

    Masashi Shingai;Yoshiaki Nishimura;Florian Klein;Hugo Mouquet

  • Differential natural killer cell–mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes

    Galit Alter;Maureen P. Martin;Nickolas Teigen;William H Carr

  • Electron tomography analysis of envelope glycoprotein trimers on HIV and simian immunodeficiency virus virions.

    Ping Zhu;Elena Chertova;Julian Bess;Jeffrey D. Lifson

  • Cytomegalovirus Vectors Violate CD8+ T Cell Epitope Recognition Paradigms

    Scott G. Hansen;Jonah B. Sacha;Colette M. Hughes;Julia C. Ford

  • Prevention of Vaginal SHIV Transmission in Rhesus Macaques Through Inhibition of CCR5

    Michael M Lederman;Ronald S Veazey;Robin Ewart Offord;Donald E Mosier

  • Effectiveness of Postinoculation (R)-9-(2-Phosphonylmethoxypropyl)Adenine Treatment for Prevention of Persistent Simian Immunodeficiency Virus SIVmne Infection Depends Critically on Timing of Initiation and Duration of Treatment

    Che-Chung Tsai;Peter Emau;Kathryn E. Follis;Thomas W. Beck

  • Highly sensitive SIV plasma viral load assay: practical considerations, realistic performance expectations, and application to reverse engineering of vaccines for AIDS.

    A. Nichole Cline;Julian W. Bess;Michael Jr Piatak;Jeffrey D. Lifson

  • Mamu-B*08-Positive Macaques Control Simian Immunodeficiency Virus Replication

    John T. Loffredo;Jess Maxwell;Ying Qi;Chrystal E. Glidden

  • Human Immunodeficiency Virus Type 1 Activates Plasmacytoid Dendritic Cells and Concomitantly Induces the Bystander Maturation of Myeloid Dendritic Cells

    Jean-François Fonteneau;Marie Larsson;Anne-Sophie Beignon;Kelli McKenna

  • Envelope Glycoprotein Incorporation, Not Shedding of Surface Envelope Glycoprotein (gp120/SU), Is the Primary Determinant of SU Content of Purified Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus

    Elena Chertova;Julian W. Bess;Bruce J. Crise;Raymond C. Sowder

  • Influence of HLA-C Expression Level on HIV Control

    Richard Apps;Richard Apps;Ying Qi;Ying Qi;Jonathan M. Carlson;Haoyan Chen;Haoyan Chen

  • Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections

    Ming Zeng;Anthony J. Smith;Stephen W. Wietgrefe;Peter J. Southern

  • Insufficient Production and Tissue Delivery of CD4+Memory T Cells in Rapidly Progressive Simian Immunodeficiency Virus Infection

    Louis J. Picker;Shoko I. Hagen;Richard Lum;Edward F. Reed-Inderbitzin

  • The High-Frequency Major Histocompatibility Complex Class I Allele Mamu-B*17 Is Associated with Control of Simian Immunodeficiency Virus SIVmac239 Replication

    Levi J. Yant;Thomas C. Friedrich;Randall C. Johnson;Gemma E. May

Frequent Co-Authors

Michael Piatak
Michael Piatak Leidos (United States)
Ronald C. Desrosiers
Ronald C. Desrosiers University of Miami
R. Paul Johnson
R. Paul Johnson Emory University
Jacob D. Estes
Jacob D. Estes Oregon Health & Science University
Louis J. Picker
Louis J. Picker Oregon Health & Science University
David C. Montefiori
David C. Montefiori Duke University
Michael K. Axthelm
Michael K. Axthelm Oregon National Primate Research Center
Agegnehu Gettie
Agegnehu Gettie Aaron Diamond AIDS Research Center
Brandon F. Keele
Brandon F. Keele National Institutes of Health
James Blanchard
James Blanchard Tulane University

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Related Online Degrees & Career Pathways

Studying Immunology in the USA opens doors to various healthcare and research careers. For those interested in combining clinical practice with immunological knowledge, becoming a Nurse Practitioner (NP) is a promising path. If you are a Family Nurse Practitioner considering advanced roles, understanding how to transition from FNP to acute care NP can be a critical step for career growth and specialization in immune-related acute conditions.

For aspiring NPs seeking to expedite their education, finding the right nurse practitioner accelerated program online is essential. These programs cater to professionals aiming to reduce the time to practice while gaining the advanced training needed for patient care in immunology-related fields.

If you are new to nursing but eager to enter the field quickly, exploring the best online RN programs for non nurses provides accessible pathways to start clinical roles that often intersect with immunology, such as infection control and immunization programs.

Additionally, many students benefit from easier entry options by enrolling in the easiest ABSN programs to get into. These accelerated Bachelor of Science in Nursing programs allow faster transitions from non-nursing backgrounds, helping students enter the healthcare workforce sooner and pursue further specialization in immunological disciplines.

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