World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
55
Citations
12156
World Ranking
14953
National Ranking
6257

Hengming Ke publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Hengming Ke sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 136 publications — 20th percentile

20% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Hengming Ke D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Hengming Ke sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 55 D-Index — 25th percentile

25% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Hengming Ke is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research spans multiple disciplines, primarily focusing on biochemistry, genetics, molecular biology, medicine, and chemistry. Within these broader fields, their work extensively covers molecular biology, organic chemistry, pharmacology, epidemiology, and physiology.

The main research topics Hengming Ke has contributed to include phosphodiesterase function and regulation, synthesis and catalytic reactions, chemical synthesis and alkaloids, cholinesterase and neurodegenerative diseases, phenothiazines and benzothiazines synthesis and activities, receptor mechanisms and signaling, and enzyme function and inhibition.

They have published in various scientific venues, frequently contributing to UNC Libraries with 33 publications, followed by OPAL (Open@LaTrobe) at La Trobe University with 5 publications. Other notable publication venues include the Journal of Medicinal Chemistry with 4 papers, Food Reviews International, and Bioorganic & Medicinal Chemistry Letters with 1 paper each.

Some recent papers authored by Hengming Ke include:

  • Advances in the Development of Phosphodiesterase-4 Inhibitors, 2020, Journal of Medicinal Chemistry
  • The Role of Probiotics in Purine Metabolism, Hyperuricemia and Gout: Mechanisms and Interventions, 2021, Food Reviews International
  • Discovery of Evodiamine Derivatives as Highly Selective PDE5 Inhibitors Targeting a Unique Allosteric Pocket, 2020, Journal of Medicinal Chemistry
  • Novel PDE5 inhibitors derived from rutaecarpine for the treatment of Alzheimer's disease, 2020, Bioorganic & Medicinal Chemistry Letters
  • Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13, 2020, UNC Libraries

The scientist collaborates with a number of frequent co-authors whose contributions span multiple publications. These include Huanchen Wang with 21 collaborations, Howard Robinson with 10, Qing Huai with 6, Hai-Bin Luo with 5, and Jiwen Cai with 5.

Best Publications

  • Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

    Sung Jun Park;Faiyaz Ahmad;Andrew Philp;Keith Baar

  • Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

    Junli Liu;Hongguang Xia;Minsu Kim;Lihua Xu

  • Advances in targeting cyclic nucleotide phosphodiesterases

    Donald H Maurice;Hengming Ke;Faiyaz Ahmad;Yousheng Wang

  • Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte.

    Rachael P. Norris;William J. Ratzan;Marina Freudzon;Lisa M. Mehlmann

  • Atomic Structure of PDE4: Insights into Phosphodiesterase Mechanism and Specificity

    Robert X. Xu;Anne M. Hassell;Dana Vanderwall;Millard H. Lambert

  • Crystal structure of calcineurin–cyclophilin–cyclosporin shows common but distinct recognition of immunophilin–drug complexes

    Qing Huai;Hwa Young Kim;Yudong Liu;Yingdong Zhao;Yingdong Zhao

  • Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function.

    James A. Olzmann;Keith Brown;Keith D. Wilkinson;Howard D. Rees

  • Crystal structures of the monofunctional chorismate mutase from Bacillus subtilis and its complex with a transition state analog

    Yuh Min Chook;Hengming Ke;William N. Lipscomb

  • The Monofunctional Chorismate Mutase from Bacillus subtilis: Structure Determination of Chorismate Mutase and Its Complexes with a Transition State Analog and Prephenate, and Implications for the Mechanism of the Enzymatic Reaction

    Yuh Min Chook;Joseph V. Gray;Joseph V. Gray;Hengming Ke;William N. Lipscomb

  • Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12–FK506 in Cryptococcus neoformans

    Deborah S. Fox;M. Cristina Cruz;Rey A. L. Sia;Hengming Ke

  • Crystal structure of recombinant human T-cell cyclophilin A at 2.5 A resolution.

    Hengming Ke;Lynne D. Zydowsky;Jun Liu;Christopher T. Walsh

  • Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development

    Huanchen Wang;Yudong Liu;Qing Huai;Jiwen Cai;Jiwen Cai

  • Crystal structures of phosphodiesterases and implications on substrate specificity and inhibitor selectivity.

    Hengming Ke;Huanchen Wang

  • Crystal Structures of Phosphodiesterases 4 and 5 in Complex with Inhibitor 3-Isobutyl-1-methylxanthine Suggest a Conformation Determinant of Inhibitor Selectivity

    Qing Huai;Yudong Liu;Sharron H. Francis;Jackie D. Corbin

  • The Crystal Structure of AMP-Bound PDE4 Suggests a Mechanism for Phosphodiesterase Catalysis†,‡

    Qing Huai;John Colicelli;Hengming Ke

  • Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity.

    Qing Huai;Huanchen Wang;Yingjie Sun;Hwa Young Kim

  • Crystal structure of DJ-1/RS and implication on familial Parkinson's disease

    Qing Huai;Yingjie Sun;Huanchen Wang;Lih Shen Chin

  • Structural insight into substrate specificity of phosphodiesterase 10.

    Huanchen Wang;Yudong Liu;Jing Hou;Jing Hou;Meiyan Zheng

  • Similarities and differences between human cyclophilin A and other beta-barrel structures. Structural refinement at 1.63 A resolution.

    Hengming Ke

  • Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors.

    Huanchen Wang;Ming Sheng Peng;Yi Chen;Jie Geng

Frequent Co-Authors

Howard Robinson
Howard Robinson Brookhaven National Laboratory
Sharron H. Francis
Sharron H. Francis Vanderbilt University
Jackie D. Corbin
Jackie D. Corbin Vanderbilt University
Thomas Seebeck
Thomas Seebeck University of Bern
William N. Lipscomb
William N. Lipscomb Harvard University
Nikolay V. Dokholyan
Nikolay V. Dokholyan Pennsylvania State University
Robert W. Colman
Robert W. Colman Temple University
Lian Li
Lian Li Emory University
Lih-Shen Chin
Lih-Shen Chin Emory University
Viacheslav O. Nikolaev
Viacheslav O. Nikolaev Universität Hamburg

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