World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
55
Citations
12156
World Ranking
14953
National Ranking
6257

Overview

Hengming Ke is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research spans multiple disciplines, primarily focusing on biochemistry, genetics, molecular biology, medicine, and chemistry. Within these broader fields, their work extensively covers molecular biology, organic chemistry, pharmacology, epidemiology, and physiology.

The main research topics Hengming Ke has contributed to include phosphodiesterase function and regulation, synthesis and catalytic reactions, chemical synthesis and alkaloids, cholinesterase and neurodegenerative diseases, phenothiazines and benzothiazines synthesis and activities, receptor mechanisms and signaling, and enzyme function and inhibition.

They have published in various scientific venues, frequently contributing to UNC Libraries with 33 publications, followed by OPAL (Open@LaTrobe) at La Trobe University with 5 publications. Other notable publication venues include the Journal of Medicinal Chemistry with 4 papers, Food Reviews International, and Bioorganic & Medicinal Chemistry Letters with 1 paper each.

Some recent papers authored by Hengming Ke include:

  • Advances in the Development of Phosphodiesterase-4 Inhibitors, 2020, Journal of Medicinal Chemistry
  • The Role of Probiotics in Purine Metabolism, Hyperuricemia and Gout: Mechanisms and Interventions, 2021, Food Reviews International
  • Discovery of Evodiamine Derivatives as Highly Selective PDE5 Inhibitors Targeting a Unique Allosteric Pocket, 2020, Journal of Medicinal Chemistry
  • Novel PDE5 inhibitors derived from rutaecarpine for the treatment of Alzheimer's disease, 2020, Bioorganic & Medicinal Chemistry Letters
  • Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13, 2020, UNC Libraries

The scientist collaborates with a number of frequent co-authors whose contributions span multiple publications. These include Huanchen Wang with 21 collaborations, Howard Robinson with 10, Qing Huai with 6, Hai-Bin Luo with 5, and Jiwen Cai with 5.

Best Publications

  • Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

    Sung Jun Park;Faiyaz Ahmad;Andrew Philp;Keith Baar

  • Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

    Junli Liu;Hongguang Xia;Minsu Kim;Lihua Xu

  • Advances in targeting cyclic nucleotide phosphodiesterases

    Donald H Maurice;Hengming Ke;Faiyaz Ahmad;Yousheng Wang

  • Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte.

    Rachael P. Norris;William J. Ratzan;Marina Freudzon;Lisa M. Mehlmann

  • Atomic Structure of PDE4: Insights into Phosphodiesterase Mechanism and Specificity

    Robert X. Xu;Anne M. Hassell;Dana Vanderwall;Millard H. Lambert

  • Crystal structure of calcineurin–cyclophilin–cyclosporin shows common but distinct recognition of immunophilin–drug complexes

    Qing Huai;Hwa Young Kim;Yudong Liu;Yingdong Zhao;Yingdong Zhao

  • Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function.

    James A. Olzmann;Keith Brown;Keith D. Wilkinson;Howard D. Rees

  • Crystal structures of the monofunctional chorismate mutase from Bacillus subtilis and its complex with a transition state analog

    Yuh Min Chook;Hengming Ke;William N. Lipscomb

  • The Monofunctional Chorismate Mutase from Bacillus subtilis: Structure Determination of Chorismate Mutase and Its Complexes with a Transition State Analog and Prephenate, and Implications for the Mechanism of the Enzymatic Reaction

    Yuh Min Chook;Joseph V. Gray;Joseph V. Gray;Hengming Ke;William N. Lipscomb

  • Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12–FK506 in Cryptococcus neoformans

    Deborah S. Fox;M. Cristina Cruz;Rey A. L. Sia;Hengming Ke

  • Crystal structure of recombinant human T-cell cyclophilin A at 2.5 A resolution.

    Hengming Ke;Lynne D. Zydowsky;Jun Liu;Christopher T. Walsh

  • Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development

    Huanchen Wang;Yudong Liu;Qing Huai;Jiwen Cai;Jiwen Cai

  • Crystal structures of phosphodiesterases and implications on substrate specificity and inhibitor selectivity.

    Hengming Ke;Huanchen Wang

  • Crystal Structures of Phosphodiesterases 4 and 5 in Complex with Inhibitor 3-Isobutyl-1-methylxanthine Suggest a Conformation Determinant of Inhibitor Selectivity

    Qing Huai;Yudong Liu;Sharron H. Francis;Jackie D. Corbin

  • The Crystal Structure of AMP-Bound PDE4 Suggests a Mechanism for Phosphodiesterase Catalysis†,‡

    Qing Huai;John Colicelli;Hengming Ke

  • Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity.

    Qing Huai;Huanchen Wang;Yingjie Sun;Hwa Young Kim

  • Crystal structure of DJ-1/RS and implication on familial Parkinson's disease

    Qing Huai;Yingjie Sun;Huanchen Wang;Lih Shen Chin

  • Structural insight into substrate specificity of phosphodiesterase 10.

    Huanchen Wang;Yudong Liu;Jing Hou;Jing Hou;Meiyan Zheng

  • Similarities and differences between human cyclophilin A and other beta-barrel structures. Structural refinement at 1.63 A resolution.

    Hengming Ke

  • Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors.

    Huanchen Wang;Ming Sheng Peng;Yi Chen;Jie Geng

Frequent Co-Authors

Howard Robinson
Howard Robinson Brookhaven National Laboratory
Sharron H. Francis
Sharron H. Francis Vanderbilt University
Jackie D. Corbin
Jackie D. Corbin Vanderbilt University
Thomas Seebeck
Thomas Seebeck University of Bern
William N. Lipscomb
William N. Lipscomb Harvard University
Nikolay V. Dokholyan
Nikolay V. Dokholyan Pennsylvania State University
Robert W. Colman
Robert W. Colman Temple University
Lian Li
Lian Li Emory University
Lih-Shen Chin
Lih-Shen Chin Emory University
Viacheslav O. Nikolaev
Viacheslav O. Nikolaev Universität Hamburg

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