What is he best known for?
The fields of study he is best known for:
Hengming Ke mainly investigates Stereochemistry, Phosphodiesterase, Active site, Crystal structure and Intracellular.
His biological study spans a wide range of topics, including Hydrolase, Crystallography and Protein structure.
The concepts of his Phosphodiesterase study are interwoven with issues in Internal medicine, Endocrinology, Cyclic nucleotide and Second messenger system.
His Active site research includes elements of Isomerase and Multiple isomorphous replacement.
His research in Crystal structure focuses on subjects like Selectivity, which are connected to Amino acid, Glutamine and Nucleophile.
Hengming Ke is doing genetic studies as part of his Biochemistry and Cell biology and Intracellular investigations.
His most cited work include:
- Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases (962 citations)
- Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13 (512 citations)
- Advances in targeting cyclic nucleotide phosphodiesterases (417 citations)
What are the main themes of his work throughout his whole career to date?
Hengming Ke spends much of his time researching Phosphodiesterase, Stereochemistry, Biochemistry, Active site and Hydrolase.
His Phosphodiesterase research incorporates elements of Glutamine, Pharmacology, Cyclic nucleotide and Second messenger system.
His Stereochemistry study integrates concerns from other disciplines, such as Protein structure, Selectivity, Crystal structure and Hydrogen bond.
His work in the fields of Biochemistry, such as Enzyme kinetics, Kinase and PDE4B, intersects with other areas such as Trypanosoma brucei.
The Active site study combines topics in areas such as Crystallography, Isomerase and Molecular model.
His work in Hydrolase addresses issues such as Substrate, which are connected to fields such as PDE10A and Biophysics.
He most often published in these fields:
- Phosphodiesterase (53.33%)
- Stereochemistry (48.89%)
- Biochemistry (32.22%)
What were the highlights of his more recent work (between 2012-2021)?
- Phosphodiesterase (53.33%)
- Stereochemistry (48.89%)
- Cell biology (11.11%)
In recent papers he was focusing on the following fields of study:
His primary areas of study are Phosphodiesterase, Stereochemistry, Cell biology, Crystal structure and Selectivity.
His Phosphodiesterase study contributes to a more complete understanding of Biochemistry.
Hengming Ke combines subjects such as Cyclic guanosine monophosphate and Active site with his study of Stereochemistry.
Hengming Ke interconnects Substrate, Yeast and Candida albicans in the investigation of issues within Active site.
His studies deal with areas such as Molecular biology and C-terminus as well as Cell biology.
His study looks at the relationship between Crystal structure and fields such as Catalysis, as well as how they intersect with chemical problems.
Between 2012 and 2021, his most popular works were:
- Advances in targeting cyclic nucleotide phosphodiesterases (417 citations)
- Discovery of Novel Trypanosoma brucei Phosphodiesterase B1 Inhibitors by Virtual Screening against the Unliganded TbrPDEB1 Crystal Structure (39 citations)
- The MDM2 RING Domain and Central Acidic Domain Play Distinct Roles in MDM2 Protein Homodimerization and MDM2-MDMX Protein Heterodimerization (27 citations)
In his most recent research, the most cited papers focused on:
Hengming Ke mainly focuses on Cell biology, Phosphodiesterase, Drug discovery, Biochemistry and Enzyme.
His Cell biology study typically links adjacent topics like Molecular biology.
His Phosphodiesterase research integrates issues from Crystal structure, Stereochemistry, Combinatorial chemistry, Selectivity and Binding pattern.
His Drug discovery course of study focuses on Pharmacology and Signalling, Pulmonary hypertension, Cyclic nucleotide, Intracellular and Cyclic nucleotide phosphodiesterases.
His study in the field of Molecular Docking Simulation and Virtual screening is also linked to topics like In silico and Trypanosoma brucei.
His Enzyme research is multidisciplinary, incorporating perspectives in Viability assay and Genetics.
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