Hengming Ke mainly investigates Stereochemistry, Phosphodiesterase, Active site, Crystal structure and Intracellular. His biological study spans a wide range of topics, including Hydrolase, Crystallography and Protein structure. The concepts of his Phosphodiesterase study are interwoven with issues in Internal medicine, Endocrinology, Cyclic nucleotide and Second messenger system.
His Active site research includes elements of Isomerase and Multiple isomorphous replacement. His research in Crystal structure focuses on subjects like Selectivity, which are connected to Amino acid, Glutamine and Nucleophile. Hengming Ke is doing genetic studies as part of his Biochemistry and Cell biology and Intracellular investigations.
Hengming Ke spends much of his time researching Phosphodiesterase, Stereochemistry, Biochemistry, Active site and Hydrolase. His Phosphodiesterase research incorporates elements of Glutamine, Pharmacology, Cyclic nucleotide and Second messenger system. His Stereochemistry study integrates concerns from other disciplines, such as Protein structure, Selectivity, Crystal structure and Hydrogen bond.
His work in the fields of Biochemistry, such as Enzyme kinetics, Kinase and PDE4B, intersects with other areas such as Trypanosoma brucei. The Active site study combines topics in areas such as Crystallography, Isomerase and Molecular model. His work in Hydrolase addresses issues such as Substrate, which are connected to fields such as PDE10A and Biophysics.
His primary areas of study are Phosphodiesterase, Stereochemistry, Cell biology, Crystal structure and Selectivity. His Phosphodiesterase study contributes to a more complete understanding of Biochemistry. Hengming Ke combines subjects such as Cyclic guanosine monophosphate and Active site with his study of Stereochemistry.
Hengming Ke interconnects Substrate, Yeast and Candida albicans in the investigation of issues within Active site. His studies deal with areas such as Molecular biology and C-terminus as well as Cell biology. His study looks at the relationship between Crystal structure and fields such as Catalysis, as well as how they intersect with chemical problems.
Hengming Ke mainly focuses on Cell biology, Phosphodiesterase, Drug discovery, Biochemistry and Enzyme. His Cell biology study typically links adjacent topics like Molecular biology. His Phosphodiesterase research integrates issues from Crystal structure, Stereochemistry, Combinatorial chemistry, Selectivity and Binding pattern.
His Drug discovery course of study focuses on Pharmacology and Signalling, Pulmonary hypertension, Cyclic nucleotide, Intracellular and Cyclic nucleotide phosphodiesterases. His study in the field of Molecular Docking Simulation and Virtual screening is also linked to topics like In silico and Trypanosoma brucei. His Enzyme research is multidisciplinary, incorporating perspectives in Viability assay and Genetics.
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Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases
Sung Jun Park;Faiyaz Ahmad;Andrew Philp;Keith Baar.
Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13
Junli Liu;Hongguang Xia;Minsu Kim;Lihua Xu.
Advances in targeting cyclic nucleotide phosphodiesterases
Donald H Maurice;Hengming Ke;Faiyaz Ahmad;Yousheng Wang.
Nature Reviews Drug Discovery (2014)
Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte.
Rachael P. Norris;William J. Ratzan;Marina Freudzon;Lisa M. Mehlmann.
Atomic Structure of PDE4: Insights into Phosphodiesterase Mechanism and Specificity
Robert X. Xu;Anne M. Hassell;Dana Vanderwall;Millard H. Lambert.
Crystal structure of calcineurin–cyclophilin–cyclosporin shows common but distinct recognition of immunophilin–drug complexes
Qing Huai;Hwa Young Kim;Yudong Liu;Yingdong Zhao;Yingdong Zhao.
Proceedings of the National Academy of Sciences of the United States of America (2002)
Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function.
James A. Olzmann;Keith Brown;Keith D. Wilkinson;Howard D. Rees.
Journal of Biological Chemistry (2004)
Crystal structures of the monofunctional chorismate mutase from Bacillus subtilis and its complex with a transition state analog
Yuh Min Chook;Hengming Ke;William N. Lipscomb.
Proceedings of the National Academy of Sciences of the United States of America (1994)
Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12–FK506 in Cryptococcus neoformans
Deborah S. Fox;M. Cristina Cruz;Rey A. L. Sia;Hengming Ke.
Molecular Microbiology (2001)
The Monofunctional Chorismate Mutase from Bacillus subtilis: Structure Determination of Chorismate Mutase and Its Complexes with a Transition State Analog and Prephenate, and Implications for the Mechanism of the Enzymatic Reaction
Yuh Min Chook;Joseph V. Gray;Joseph V. Gray;Hengming Ke;William N. Lipscomb.
Journal of Molecular Biology (1994)
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