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Biology and Biochemistry

D-Index
47
Citations
7018
World Ranking
18766
National Ranking
360

Overview

Thomas Seebeck is affiliated with the University of Bern in Switzerland and has contributed to the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their research focuses significantly on the study of phosphodiesterase function and regulation, enzyme function and inhibition, and disease-causing protozoans such as Leishmania and Trypanosoma species.

Their main subfields of study include Molecular Biology, Public Health, Environmental and Occupational Health, Organic Chemistry, Biochemistry, and Epidemiology. The scientific topics covered by their work reveal a concentration on parasite biology and medicinal chemistry, particularly involving the inhibition of enzymes as potential drug targets.

Thomas Seebeck has authored several recent papers, addressing various aspects of phosphodiesterase enzymes and parasitic diseases. Notable publications include:

  • Crystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitors, 2020, UNC Libraries
  • Discovery of Novel Trypanosoma brucei Phosphodiesterase B1 Inhibitors by Virtual Screening against the Unliganded TbrPDEB1 Crystal Structure, 2020, OPAL (Open@LaTrobe) (La Trobe University)
  • Phosphodiesterase inhibitors as a new generation of antiprotozoan drugs: exploiting the benefit of enzymes that are highly conserved between host and parasite, 2020, UNC Libraries
  • Biological and Structural Characterization of Trypanosoma cruzi Phosphodiesterase C and Implications for Design of Parasite Selective Inhibitors, 2020, UNC Libraries

Their frequent co-authors include Hengming Ke, Huanchen Wang, Stefan Kunz, Zier Yan, and Jie Geng, reflecting collaboration primarily within biochemical and parasitological research teams.

Thomas Seebeck's research has been published predominantly in venues such as UNC Libraries and OPAL (Open@LaTrobe) at La Trobe University, suggesting engagement with institutional open access repositories.

Best Publications

  • MHC-dependent mate preferences in humans

    Claus Wedekind;Thomas Seebeck;Florence Bettens;Alexander J. Paepke

  • A vector series for rapid PCR-mediated C-terminal in situ tagging of Trypanosoma brucei genes.

    Michael Oberholzer;Sabine Morand;Stefan Kunz;Thomas Seebeck

  • Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei.

    Enock Matovu;Mhairi L. Stewart;Federico Geiser;Reto Brun

  • Distinct localization and cell cycle dependence of COOH terminally tyrosinolated alpha-tubulin in the microtubules of Trypanosoma brucei brucei.

    T Sherwin;A Schneider;R Sasse;T Seebeck

  • The Trypanosoma brucei cAMP phosphodiesterases TbrPDEB1 and TbrPDEB2: flagellar enzymes that are essential for parasite virulence

    Michael Oberholzer;Gabriela Marti;Mario Baresic;Stefan Kunz

  • Drug resistance in Trypanosoma brucei spp., the causative agents of sleeping sickness in man and nagana in cattle.

    Enock Matovu;Thomas Seebeck;John C.K. Enyaru;Ronald Kaminsky

  • Genetic variants of the TbAT1 adenosine transporter from African trypanosomes in relapse infections following melarsoprol therapy.

    Enock Matovu;Federico Geiser;Vreni Schneider;Pascal Mäser

  • Subpellicular and flagellar microtubules of Trypanosoma brucei brucei contain the same alpha-tubulin isoforms.

    Andre Schneider;Trevor Sherwin;Rosemary Sasse;David G. Russell

  • Tubulin genes of Trypanosoma brucei: a tightly clustered family of alternating genes.

    Thomas Seebeck;Paul A. Whittaker;Martin A. Imboden;Norman Hardman

  • The major component of the paraflagellar rod of Trypanosoma brucei is a helical protein that is encoded by two identical, tandemly linked genes.

    K Schlaeppi;J Deflorin;T Seebeck

  • Production of a recombinant antigen of Echinococcus multilocularis with high immunodiagnostic sensitivity and specificity

    Monique Vogel;Bruno Gottstein;Norbert Müller;Thomas Seebeck

  • Pharmacological validation of Trypanosoma brucei phosphodiesterases as novel drug targets

    Harry P. de Koning;Matthew K. Gould;Geert Jan Sterk;Hermann Tenor

  • Genetic nomenclature for Trypanosoma and Leishmania

    C Clayton;M Adams;R. Almeida;T Baltz

  • Transcription of the intergenic regions of the tubulin gene cluster of Trypanosoma brucei: evidence for a polyclstronic transcription unit in a eukaryote

    Martin A. Imboden;Peter W. Laird;Marianne Affolter;Thomas Seebeck

  • Melarsoprol refractory T. b. gambiense from Omugo, north-western Uganda.

    E. Matovu;J. C. K. Enyaru;D. Legros;C. Schmid

  • Polyamine-mediated phosphorylation of a nucleolar protein from Physarum polycephalum that stimulates rRNA synthesis.

    Glenn D. Kuehn;Hans-Urs Affolter;Valerie J. Atmar;Thomas Seebeck

  • Trypanocidal action of neuroleptic phenothiazines in Trypanosoma brucei.

    Thomas Seebeck;Peter Gehr

  • The major components of the paraflagellar rod of Trypanosoma brucei are two similar, but distinct proteins which are encoded by two different gene loci.

    J Deflorin;M Rudolf;T Seebeck

  • Propidium iodide-based methods for monitoring drug action in the kinetoplastidae: Comparison with the Alamar Blue assay

    Matthew K. Gould;Xuan Lan Vu;Thomas Seebeck;Harry P. de Koning

  • Crystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite selective inhibitors

    Huanchen Wang;Zier Yan;Jie Geng;Stefan Kunz

Frequent Co-Authors

Andrew Hemphill
Andrew Hemphill University of Bern
Norbert Müller
Norbert Müller University of Bern
André Schneider
André Schneider University of Bern
Reto Brun
Reto Brun University of Basel
Hengming Ke
Hengming Ke University of North Carolina at Chapel Hill
Bruno Gottstein
Bruno Gottstein University of Bern
Harry P. de Koning
Harry P. de Koning University of Glasgow
Keith Gull
Keith Gull University of Oxford
Pascal Mäser
Pascal Mäser Swiss Tropical and Public Health Institute
Iwan J. P. de Esch
Iwan J. P. de Esch Vrije Universiteit Amsterdam

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