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Molecular Biology

D-Index
54
Citations
8058
World Ranking
2344
National Ranking
39

Overview

Isabel Roditi is affiliated with the University of Bern in Switzerland, specializing in research that intersects medicine, biochemistry, genetics, molecular biology, and agricultural and biological sciences. Their work spans several subfields including epidemiology, molecular biology, public health, environmental and occupational health, insect science, and physiology.

Their primary research focus covers a range of topics: Trypanosoma species research and its implications, insect symbiosis and bacterial influences, studies related to Leishmaniasis, biochemical and molecular research, cardiomyopathy and myosin studies, investigations on chitinases and chitosanases, and applications of CRISPR and genetic engineering.

Roditi's recent papers highlight diverse aspects of African trypanosomes and related parasitology fields. Notable publications include:

  • "Cyclic AMP signalling and glucose metabolism mediate pH taxis by African trypanosomes" (2022) published in Nature Communications
  • "Developmental changes and metabolic reprogramming during establishment of infection and progression of Trypanosoma brucei brucei through its insect host" (2021) published in PLoS neglected tropical diseases
  • "The sweet and sour sides of trypanosome social motility" (2023) published in Trends in Parasitology
  • "An Alba-domain protein required for proteome remodelling during trypanosome differentiation and host transition" (2021) published in PLoS Pathogens
  • "A transient CRISPR/Cas9 expression system for genome editing in Trypanosoma brucei" (2020) published in BMC Research Notes

The scientist collaborates frequently with a number of colleagues, including Arunasalam Naguleswaran, Sebastian Knüsel, Mattias Benninger, Ruth Rehmann, and Sebastian Shaw.

Preferred publication venues for Isabel Roditi's work include bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, mBio, Journal of Biological Chemistry, and the Bern Open Repository and Information System (University of Bern).

Best Publications

  • Procyclin gene expression and loss of the variant surface glycoprotein during differentiation of Trypanosoma brucei.

    I Roditi;H Schwarz;T W Pearson;R P Beecroft

  • Polydnaviruses of braconid wasps derive from an ancestral nudivirus.

    Annie Bézier;Marc Annaheim;Juline Herbinière;Christoph Wetterwald

  • Highly efficient stable transformation of bloodstream forms of Trypanosoma brucei.

    Gabriela Burkard;Cristina M. Fragoso;Isabel Roditi

  • Genome-wide RNAi screens in bloodstream form trypanosomes identify drug transporters.

    Gabriela Schumann Burkard;Pascal Jutzi;Isabel Roditi

  • Expression of a polypeptide containing a dipeptide repeat is confined to the insect stage of Trypanosoma brucei

    Isabel Roditi;Mark Carrington;Mervyn Turner

  • Spliced leader trapping reveals widespread alternative splicing patterns in the highly dynamic transcriptome of Trypanosoma brucei

    Daniel Nilsson;Kapila Gunasekera;Jan Mani;Magne Osteras

  • Elements in the 3' untranslated region of procyclin mRNA regulate expression in insect forms of Trypanosoma brucei by modulating RNA stability and translation.

    A Furger;N Schürch;U Kurath;I Roditi

  • The surface coat of procyclic Trypanosoma brucei: programmed expression and proteolytic cleavage of procyclin in the tsetse fly.

    Alvaro Acosta-Serrano;Alvaro Acosta-Serrano;Erik Vassella;Matthias Liniger;Christina Kunz Renggli

  • DNA from Protozoan Parasites Babesia bovis, Trypanosoma cruzi, and T. brucei Is Mitogenic for B Lymphocytes and Stimulates Macrophage Expression of Interleukin-12, Tumor Necrosis Factor Alpha, and Nitric Oxide

    Lisl K. M. Shoda;Kimberly A. Kegerreis;Carlos E. Suarez;Isabel Roditi

  • A major surface glycoprotein of Trypanosoma brucei is expressed transiently during development and can be regulated post-transcriptionally by glycerol or hypoxia

    Erik Vassella;Jan Van Den Abbeele;Peter Bütikofer;Christina Kunz Renggli

  • Variant specific glycoprotein of Trypanosoma brucei consists of two domains each having an independently conserved pattern of cysteine residues.

    Mark Carrington;Nancy Miller;Michael Blum;Isabel Roditi

  • A conserved stem-loop structure in the 3' untranslated region of procyclin mRNAs regulates expression in Trypanosoma brucei

    Adrian Hehl;Erik Vassella;Richard Braun;Isabel Roditi

  • Trypanosoma brucei: constitutive activity of the VSG and procyclin gene promoters.

    E. Pays;H. Coquelet;P. Tebabi;A. Pays

  • Survival of Trypanosoma brucei in the Tsetse Fly Is Enhanced by the Expression of Specific Forms of Procyclin

    Stefan Ruepp;André Furger;Ursula Kurath;Christina Kunz Renggli

  • Haemonchus contortus acetylcholine receptors of the DEG-3 subfamily and their role in sensitivity to monepantel.

    Lucien Rufener;Pascal Mäser;Isabel Roditi;Ronald Kaminsky

  • Alba-domain proteins of Trypanosoma brucei are cytoplasmic RNA-binding proteins that interact with the translation machinery.

    Jan Mani;Andreas Güttinger;Bernd Schimanski;Manfred Heller

  • Unravelling the procyclin coat of Trypanosoma brucei.

    I. Roditi;A. Furger;S. Ruepp;N. Schürch

  • 2·9 Å resolution structure of the N-terminal domain of a variant surface glycoprotein from Trypanosoma brucei

    Douglas Freymann;James Down;Mark Carrington;Isabel Roditi

  • Accurate polyadenylation of procyclin mRNAs in Trypanosoma brucei is determined by pyrimidine-rich elements in the intergenic regions

    N Schürch;A Hehl;E Vassella;R Braun

  • A family of stage-specific alanine-rich proteins on the surface of epimastigote forms of Trypanosoma brucei.

    Simon Urwyler;Erwin Studer;Christina Kunz Renggli;Isabel Roditi

Frequent Co-Authors

Reto Brun
Reto Brun University of Basel
Andrew Hemphill
Andrew Hemphill University of Bern
Pascal Mäser
Pascal Mäser Swiss Tropical and Public Health Institute
Richard O. Williams
Richard O. Williams University of Oxford
Paul T. Englund
Paul T. Englund Johns Hopkins University
Adrian B. Hehl
Adrian B. Hehl University of Zurich
Mark Carrington
Mark Carrington University of Cambridge
Etienne Pays
Etienne Pays Université Libre de Bruxelles
André Schneider
André Schneider University of Bern
Wendy Gibson
Wendy Gibson University of Bristol

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