2020 - Fellow of the Royal Society, United Kingdom
His main research concerns Trypanosoma brucei, Cell biology, Cellular differentiation, RNA and Biochemistry. His Trypanosoma brucei research is multidisciplinary, incorporating elements of Phosphatase, Protozoa, Tsetse fly, Trypanosoma and Axoneme. His Organelle study, which is part of a larger body of work in Cell biology, is frequently linked to Protein targeting, bridging the gap between disciplines.
His Cellular differentiation research is multidisciplinary, incorporating perspectives in Regulation of gene expression, RNA interference, Signal transduction and Cell division. His work in Regulation of gene expression covers topics such as Gene expression which are related to areas like Phenotype. His work on Genome, Pseudogene and RNA polymerase as part of his general Gene study is frequently connected to Proteolytic enzymes and General transcription factor, thereby bridging the divide between different branches of science.
His primary scientific interests are in Trypanosoma brucei, Cell biology, Genetics, Trypanosoma and Gene expression. The concepts of his Trypanosoma brucei study are interwoven with issues in Evolutionary biology, Regulation of gene expression and RNA interference. Keith R. Matthews has researched Cell biology in several fields, including Quorum sensing, Cell cycle and Cellular differentiation.
The various areas that Keith R. Matthews examines in his Trypanosoma study include Trypanosomiasis and Antigenic variation. His Gene expression study also includes
His primary areas of investigation include Trypanosoma brucei, Cell biology, Quorum sensing, Trypanosoma and Regulation of gene expression. His work carried out in the field of Trypanosoma brucei brings together such families of science as Evolutionary biology, Gene expression, Basement membrane, Matrix and Extracellular matrix. His Gene expression research integrates issues from Proteome and Genome.
His biological study spans a wide range of topics, including Glycosome and Gene, Virulence. The study incorporates disciplines such as Gene silencing and Signal transduction in addition to Quorum sensing. His work in Regulation of gene expression addresses issues such as Mutant, which are connected to fields such as Protein kinase A.
Keith R. Matthews spends much of his time researching Cell biology, Trypanosoma brucei, Quorum sensing, Trypanosoma and Signal transduction. He has included themes like Transporter and Virulence in his Cell biology study. His work blends Trypanosoma brucei and Tropism studies together.
He interconnects Host, Computational biology, Protozoa and Bacteria in the investigation of issues within Quorum sensing. His Trypanosoma study incorporates themes from Gene expression, Gene expression profiling, Messenger RNA, Gene and Regulation of gene expression. Keith R. Matthews has included themes like RNA interference and Gene silencing in his Signal transduction study.
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The genome of the kinetoplastid parasite, Leishmania major.
Alasdair C. Ivens;Christopher S. Peacock;Elizabeth A. Worthey;Lee Murphy.
The developmental cell biology of Trypanosoma brucei.
Keith R. Matthews.
Journal of Cell Science (2005)
A common pyrimidine-rich motif governs trans-splicing and polyadenylation of tubulin polycistronic pre-mRNA in trypanosomes.
Keith R. Matthews;Christian Tschudi;Elisabetta Ullu.
Genes & Development (1994)
A novel epitope tag system to study protein targeting and organelle biogenesis in Trypanosoma brucei.
P Bastin;Z Bagherzadeh;Keith Matthews;K Gull.
Molecular and Biochemical Parasitology (1996)
Temporal order of RNA-processing reactions in trypanosomes: rapid trans splicing precedes polyadenylation of newly synthesized tubulin transcripts.
E Ullu;K R Matthews;C Tschudi.
Molecular and Cellular Biology (1993)
A surface transporter family conveys the trypanosome differentiation signal.
Samuel Dean;Rosa Marchetti;Kiaran Kirk;Keith R. Matthews.
The cell biology of Trypanosoma brucei differentiation.
Katelyn Fenn;Keith R Matthews.
Current Opinion in Microbiology (2007)
Genome-wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei
Binny M. Mony;Paula MacGregor;Alasdair Ivens;Federico Rojas.
Evidence for an interplay between cell cycle progression and the initiation of differentiation between life cycle forms of African trypanosomes
Keith R. Matthews;Keith Gull.
Journal of Cell Biology (1994)
Genome-wide expression profiling of in vivo- derived bloodstream parasite stages and dynamic analysis of mRNA alterations during synchronous differentiation in Trypanosoma brucei
Sarah Kabani;Katelyn Fenn;Alan Ross;Al Ivens.
BMC Genomics (2009)
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