World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
10515
World Ranking
14503
National Ranking
1145

Research.com Recognitions

  • 2020 - Fellow of the Royal Society, United Kingdom

Overview

Keith R. Matthews is affiliated with the University of Edinburgh in the United Kingdom. Their research primarily spans the fields of Medicine and Agricultural and Biological Sciences, with significant focus on subfields such as Epidemiology, Public Health, Environmental and Occupational Health, Insect Science, Molecular Biology, and Immunology.

The scientist's work covers a broad range of topics related to parasitology and infectious diseases, including:

  • Trypanosoma species research and implications
  • Research on Leishmaniasis Studies
  • Insect symbiosis and bacterial influences
  • Immune Cell Function and Interaction
  • Mosquito-borne diseases and control
  • Plant Virus Research Studies
  • CRISPR and Genetic Engineering

Keith R. Matthews has contributed extensively to the study of African trypanosomes and their biological processes, including quorum sensing and cellular signaling mechanisms. Recent publications highlight these efforts and include:

  • "Single-cell transcriptomic analysis of bloodstream Trypanosoma brucei reconstructs cell cycle progression and developmental quorum sensing," 2021, Nature Communications
  • "A systematic analysis of Trypanosoma brucei chromatin factors identifies novel protein interaction networks associated with sites of transcription initiation and termination," 2021, Genome Research
  • "Trypanosome Signaling-Quorum Sensing," 2021, Annual Review of Microbiology
  • "Pathogenicity and virulence of African trypanosomes: From laboratory models to clinically relevant hosts," 2022, Virulence
  • "An atypical DYRK kinase connects quorum-sensing with posttranscriptional gene regulation in Trypanosoma brucei," 2020, eLife

Frequent collaborators throughout these research activities include:

  • Mathieu Cayla
  • Emma M. Briggs
  • Guy R Oldrieve
  • Alasdair Ivens
  • Liam J. Morrison

The primary venues for Keith R. Matthews' work are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Zenodo (CERN European Organization for Nuclear Research)
  • eLife
  • Trends in Parasitology

In recognition of their contributions to the scientific community, Keith R. Matthews was awarded the distinction of Fellow of the Royal Society, United Kingdom, in 2020.

Best Publications

  • The genome of the kinetoplastid parasite, Leishmania major.

    Alasdair C. Ivens;Christopher S. Peacock;Elizabeth A. Worthey;Lee Murphy

  • The developmental cell biology of Trypanosoma brucei

    Keith R. Matthews

  • A common pyrimidine-rich motif governs trans-splicing and polyadenylation of tubulin polycistronic pre-mRNA in trypanosomes.

    Keith R. Matthews;Christian Tschudi;Elisabetta Ullu

  • A novel epitope tag system to study protein targeting and organelle biogenesis in Trypanosoma brucei.

    P Bastin;Z Bagherzadeh;Keith Matthews;K Gull

  • Temporal order of RNA-processing reactions in trypanosomes: rapid trans splicing precedes polyadenylation of newly synthesized tubulin transcripts.

    E Ullu;K R Matthews;C Tschudi

  • A surface transporter family conveys the trypanosome differentiation signal.

    Samuel Dean;Rosa Marchetti;Kiaran Kirk;Keith R. Matthews

  • Genome-wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei

    Binny M. Mony;Paula MacGregor;Alasdair Ivens;Federico Rojas

  • The cell biology of Trypanosoma brucei differentiation.

    Katelyn Fenn;Keith R Matthews

  • Evidence for an interplay between cell cycle progression and the initiation of differentiation between life cycle forms of African trypanosomes

    Keith R. Matthews;Keith Gull

  • Drug resistance in eukaryotic microorganisms

    Alan H. Fairlamb;Neil A. R. Gow;Keith R. Matthews;Andrew P. Waters

  • Genome-wide expression profiling of in vivo- derived bloodstream parasite stages and dynamic analysis of mRNA alterations during synchronous differentiation in Trypanosoma brucei

    Sarah Kabani;Katelyn Fenn;Alan Ross;Al Ivens

  • Trypanosomal immune evasion, chronicity and transmission: an elegant balancing act.

    Paula MacGregor;Balazs Szöőr;Nicholas J. Savill;Keith R. Matthews

  • Molecular regulation of the life cycle of African trypanosomes.

    Keith R. Matthews;James R. Ellis;Athina Paterou

  • A novel CCCH protein which modulates differentiation of Trypanosoma brucei to its procyclic form

    Edward F. Hendriks;Derrick R. Robinson;Derrick R. Robinson;Matthew Hinkins;Keith R. Matthews

  • Oligopeptide signaling through TbGPR89 drives Trypanosome Quorum sensing

    Federico Rojas;Eleanor Silvester;Julie Young;Rachel Milne

  • A novel phosphatase cascade regulates differentiation in Trypanosoma brucei via a glycosomal signaling pathway

    Balázs Szöor;Irene Ruberto;Richard Burchmore;Keith R Matthews

  • Transcriptome-wide analysis of trypanosome mRNA decay reveals complex degradation kinetics and suggests a role for co-transcriptional degradation in determining mRNA levels.

    Abeer A. Fadda;Mark Ryten;Dorothea Droll;Federico Rojas

  • Protein tyrosine phosphatase TbPTP1: A molecular switch controlling life cycle differentiation in trypanosomes

    Balázs Szöor;Jude Wilson;Helen McElhinney;Helen McElhinney;Lydia Tabernero

  • Transmission Stages Dominate Trypanosome Within-Host Dynamics during Chronic Infections

    Paula MacGregor;Nicholas J. Savill;Deborah J. Hall;Keith R. Matthews

  • Flagellar morphogenesis: protein targeting and assembly in the paraflagellar rod of trypanosomes.

    Philippe Bastin;Thomas H. MacRae;Susan B. Francis;Keith R. Matthews

Frequent Co-Authors

Keith Gull
Keith Gull University of Oxford
Alasdair Ivens
Alasdair Ivens University of Edinburgh
Christine Clayton
Christine Clayton Heidelberg University
Mark C. Field
Mark C. Field University of Dundee
Barbara M. Bakker
Barbara M. Bakker University Medical Center Groningen
Hans V. Westerhoff
Hans V. Westerhoff Vrije Universiteit Amsterdam
Terry K. Smith
Terry K. Smith University of St Andrews
Michael P. Barrett
Michael P. Barrett University of Glasgow
Peter J. Myler
Peter J. Myler Seattle Children's Hospital
David Horn
David Horn University of Dundee

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