2026 Donald Hilvert: Chemistry Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Chemistry	93	1827	1628	39	35	405	25566

Discipline name

D-Index

World Ranking

Current World Ranking

National Ranking

Current National Ranking

Publications

Citations

Chemistry

1827

1628

405

25566

Research.com Recognitions

2016 - Fellow of the American Academy of Arts and Sciences
1993 - Fellow of the American Association for the Advancement of Science (AAAS)
1991 - Fellow of Alfred P. Sloan Foundation

Overview

Donald Hilvert is affiliated with ETH Zurich in Switzerland and has conducted research primarily within the fields of Biochemistry, Genetics, and Molecular Biology. Their work spans multiple subfields, including Molecular Biology, Materials Chemistry, Radiology, Nuclear Medicine and Imaging, Ecology, and Pharmacology.

The research topics addressed by Hilvert include:

Enzyme Catalysis and Immobilization
Protein Structure and Dynamics
Chemical Synthesis and Analysis
Enzyme Structure and Function
Microbial Metabolic Engineering and Bioproduction
Bacteriophages and microbial interactions
Microbial Natural Products and Biosynthesis

Hilvert has published extensively, with recent notable papers including:

"An evolution-based model for designing chorismate mutase enzymes," 2020, Science
"The road to fully programmable protein catalysis," 2022, Nature
"How directed evolution reshapes the energy landscape in an enzyme to boost catalysis," 2020, Science
"Protein Cages: From Fundamentals to Advanced Applications," 2022, Chemical Reviews
"Evolution of dynamical networks enhances catalysis in a designer enzyme," 2021, Nature Chemistry

Common publication venues for Hilvert's work are:

bioRxiv (Cold Spring Harbor Laboratory)
Faraday Discussions
Nature Communications
ACS Catalysis
Journal of the American Chemical Society

Hilvert frequently collaborates with other researchers, including:

H. Adrian Bunzel
Mikail D. Levasseur
Thomas G. W. Edwardson
T.M. Schmeing
Marcel Grogg

The scientist has received several fellowships, including:

Fellow of the American Academy of Arts and Sciences (2016)
Fellow of the American Association for the Advancement of Science (AAAS) (1993)
Fellow of Alfred P. Sloan Foundation (1991)

Best Publications

De novo computational design of retro-aldol enzymes.

Lin Jiang;Eric A. Althoff;Fernando R. Clemente;Lindsey Doyle

1449
Citations
Computational design of an enzyme catalyst for a stereoselective bimolecular Diels-Alder reaction

Justin B. Siegel;Alexandre Zanghellini;Helena M. Lovick;Gert Kiss

1144
Citations
Directed Evolution of Protein Catalysts.

Cathleen Zeymer;Donald Hilvert

520
Citations
Protein Design by Directed Evolution

Christian Jäckel;Peter Kast;Donald Hilvert

510
Citations
Directed Evolution of a Protein Container

Bigna Wörsdörfer;Kenneth J. Woycechowsky;Donald Hilvert

431
Citations
The road to fully programmable protein catalysis

Unknown

414
Citations
Emergence of a catalytic tetrad during evolution of a highly active artificial aldolase

Richard Obexer;Alexei Godina;Alexei Godina;Xavier Garrabou;Peer R. E. Mittl

385
Citations
Iterative approach to computational enzyme design

Heidi K. Privett;Gert Kiss;Toni M. Lee;Rebecca Blomberg

384
Citations
Precision is essential for efficient catalysis in an evolved Kemp eliminase

Rebecca Blomberg;Hajo Kries;Daniel M. Pinkas;Peer R. E. Mittl

368
Citations
Critical Analysis of Antibody Catalysis

Donald Hilvert

354
Citations
Evolution of a designed retro-aldolase leads to complete active site remodeling

Lars Giger;Sami Caner;Richard Obexer;Peter Kast

350
Citations
An evolution-based model for designing chorismate mutase enzymes.

William P. Russ;Matteo Figliuzzi;Christian Stocker;Pierre Barrat-Charlaix;Pierre Barrat-Charlaix

346
Citations
Antibody catalysis of the Diels-Alder reaction

Donald Hilvert;Kenneth W. Hill;Karen D. Nared;Maria Teresa M. Auditor

345
Citations
Minimalist active-site redesign: teaching old enzymes new tricks.

Miguel D. Toscano;Kenneth J. Woycechowsky;Donald Hilvert

338
Citations
Selenosubtilisin as a glutathione peroxidase mimic

Zhen Ping Wu;Donald Hilvert

324
Citations
De novo enzymes by computational design.

Hajo Kries;Rebecca Blomberg;Donald Hilvert

278
Citations
Investigating and Engineering Enzymes by Genetic Selection.

Sean V. Taylor;Peter Kast;Donald Hilvert

261
Citations
Conversion of a protease into an acyl transferase: selenolsubtilisin

Zhen Ping Wu;Donald Hilvert

245
Citations
Design of Protein Catalysts

Donald Hilvert

242
Citations
Routes to catalysis: structure of a catalytic antibody and comparison with its natural counterpart

Matthew R. Haynes;Enrico A. Stura;Donald Hilvert;Ian A. Wilson

219
Citations
Large rate accelerations in antibody catalysis by strategic use of haptenic charge

Simon N. Thorn;Richard G. Daniels;Maria-Teresa M. Auditor;Donald Hilvert

207
Citations

Frequent Co-Authors

David Baker University of Washington

Ian A. Wilson Scripps Research Institute

Kendall N. Houk University of California, Los Angeles

Kazuya Kikuchi Osaka University

Wilfred F. van Gunsteren ETH Zurich

Barry L. Stoddard Fred Hutchinson Cancer Research Center

Maksym V. Kovalenko ETH Zurich

Andrew D. Griffiths PSL University

William J. Rutter University of California, San Francisco

Nenad Ban ETH Zurich

External Links

Personal website of Donald Hilvert

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