2023 - Research.com Chemistry in Switzerland Leader Award
2016 - Fellow of the American Academy of Arts and Sciences
1993 - Fellow of the American Association for the Advancement of Science (AAAS)
1991 - Fellow of Alfred P. Sloan Foundation
The scientist’s investigation covers issues in Stereochemistry, Catalysis, Biochemistry, Protein engineering and Directed evolution. Donald Hilvert has researched Stereochemistry in several fields, including Diels–Alder reaction, Hydrolase, Chorismate mutase, Active site and Substrate. His Catalysis research is multidisciplinary, relying on both Combinatorial chemistry, Hapten and Rational design.
His research on Biochemistry frequently links to adjacent areas such as Biophysics. His research integrates issues of Protein structure, Enzyme catalysis and Protein folding in his study of Protein engineering. His studies in Directed evolution integrate themes in fields like Mutagenesis, Protein design and Nanotechnology.
Donald Hilvert mainly focuses on Stereochemistry, Biochemistry, Catalysis, Chorismate mutase and Enzyme. Donald Hilvert studied Stereochemistry and Active site that intersect with Enzyme catalysis and Binding site. His Biochemistry research includes elements of Biophysics and Antibody.
His Catalysis research incorporates themes from Combinatorial chemistry, Carboxylate and Hapten. His Chorismate mutase research integrates issues from Isomerase, Crystallography, Computational biology and Protein structure. His research links Protein design with Protein engineering.
His scientific interests lie mostly in Directed evolution, Stereochemistry, Lumazine synthase, Biophysics and Catalysis. His work deals with themes such as Combinatorial chemistry, Protein engineering, Non canonical and Biocatalysis, which intersect with Directed evolution. The concepts of his Stereochemistry study are interwoven with issues in Myoglobin, Mutant, Enzyme kinetics, Heme and Transition state analog.
His research in Lumazine synthase intersects with topics in Aquifex aeolicus, Self-assembly, Nanoreactor, Cell specific and Antibody. His is involved in several facets of Catalysis study, as is seen by his studies on Active site and Enzyme catalysis. His Active site research is multidisciplinary, incorporating elements of Side chain and Ethyl diazoacetate.
Donald Hilvert spends much of his time researching Directed evolution, Protein engineering, Nanotechnology, Throughput and Biochemical engineering. The various areas that Donald Hilvert examines in his Directed evolution study include Oxidase test, Substrate and Cyclohexylamine oxidase. His work carried out in the field of Protein engineering brings together such families of science as Rational engineering, RNA metabolism and Oligonucleotide.
His work in the fields of Nanobiotechnology overlaps with other areas such as Artificial Organelles. The study incorporates disciplines such as Lumazine synthase and Enzyme in addition to Catalysis. In his study, which falls under the umbrella issue of Function, Stereochemistry is strongly linked to Directed Molecular Evolution.
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De novo computational design of retro-aldol enzymes.
Lin Jiang;Eric A. Althoff;Fernando R. Clemente;Lindsey Doyle.
Computational design of an enzyme catalyst for a stereoselective bimolecular Diels-Alder reaction
Justin B. Siegel;Alexandre Zanghellini;Helena M. Lovick;Gert Kiss.
Protein Design by Directed Evolution
Christian Jäckel;Peter Kast;Donald Hilvert.
Annual Review of Biophysics (2008)
Directed Evolution of a Protein Container
Bigna Wörsdörfer;Kenneth J. Woycechowsky;Donald Hilvert.
Antibody catalysis of the Diels-Alder reaction
Donald Hilvert;Kenneth W. Hill;Karen D. Nared;Maria Teresa M. Auditor.
Journal of the American Chemical Society (1989)
Critical Analysis of Antibody Catalysis
Annual Review of Biochemistry (2000)
Directed Evolution of Protein Catalysts.
Cathleen Zeymer;Donald Hilvert.
Annual Review of Biochemistry (2018)
Iterative approach to computational enzyme design
Heidi K. Privett;Gert Kiss;Toni M. Lee;Rebecca Blomberg.
Proceedings of the National Academy of Sciences of the United States of America (2012)
Selenosubtilisin as a glutathione peroxidase mimic
Zhen Ping Wu;Donald Hilvert.
Journal of the American Chemical Society (1990)
Minimalist active-site redesign: teaching old enzymes new tricks.
Miguel D. Toscano;Kenneth J. Woycechowsky;Donald Hilvert.
Angewandte Chemie (2007)
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