World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
80
Citations
26046
World Ranking
992
National Ranking
524

Overview

Barry L. Stoddard is affiliated with the Fred Hutchinson Cancer Research Center in the United States. Their research primarily spans the field of Biochemistry, Genetics and Molecular Biology, with a strong focus on Molecular Biology, Ecology, Genetics, Oncology, and Molecular Medicine.

Their work covers a range of scientific topics, including:

  • Bacteriophages and microbial interactions
  • CRISPR and Genetic Engineering
  • Advanced biosensing and bioanalysis techniques
  • RNA and protein synthesis mechanisms
  • RNA modifications and cancer
  • Bacterial Genetics and Biotechnology
  • Antibiotic Resistance in Bacteria

Examples of recent research papers include:

  • Incorporation of sensing modalities into de novo designed fluorescence-activating proteins, 2021, Nature Communications
  • Identification and characterization of the WYL BrxR protein and its gene as separable regulatory elements of a BREX phage restriction system, 2022, Nucleic Acids Research
  • Immunization with a self-assembling nanoparticle vaccine displaying EBV gH/gL protects humanized mice against lethal viral challenge, 2022, Cell Reports Medicine
  • The novel anti-CRISPR AcrIIA22 relieves DNA torsion in target plasmids and impairs SpyCas9 activity, 2021, PLoS Biology
  • Structure, substrate binding and activity of a unique AAA+ protein: the BrxL phage restriction factor, 2023, Nucleic Acids Research

The scientist frequently collaborates with peers such as Lindsey Doyle, Madison Kennedy, Betty Shen, Irina Novikova, and Rose Marie Haynes. These collaborations are reflected in the number of joint publications.

Barry L. Stoddard's papers are often published in venues including:

  • OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nucleic Acids Research
  • The FASEB Journal
  • Nature Communications

Through their body of work, they have contributed to advancing understanding in molecular mechanisms, phage biology, and biotechnological approaches to genetic engineering and biosensing. Their research output reflects engagement with complex biological systems, particularly in microbial genetics and interactions, as well as innovative methods in protein engineering and immunological studies.

Best Publications

  • Design of a Novel Globular Protein Fold with Atomic-Level Accuracy

    Brian A Kuhlman;Gautam Dantas;Gregory C. Ireton;Gabriele Varani

  • De novo computational design of retro-aldol enzymes.

    Lin Jiang;Eric A. Althoff;Fernando R. Clemente;Lindsey Doyle

  • Computational design of an enzyme catalyst for a stereoselective bimolecular Diels-Alder reaction

    Justin B. Siegel;Alexandre Zanghellini;Helena M. Lovick;Gert Kiss

  • A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes

    Richard J. Roberts;Marlene Belfort;Timothy Bestor;Ashok S. Bhagwat

  • The Crystal Structure of TAL Effector PthXo1 Bound to Its DNA Target

    Amanda Nga Sze Mak;Philip Bradley;Raul A. Cernadas;Adam J. Bogdanove

  • Homing endonuclease structure and function.

    Barry L. Stoddard

  • Homing endonucleases: structural and functional insight into the catalysts of intron/intein mobility

    Brett S. Chevalier;Barry L. Stoddard

  • Capturing the Structure of a Catalytic RNA Intermediate: The Hammerhead Ribozyme

    William G. Scott;James B. Murray;John R. P. Arnold;Barry L. Stoddard

  • The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate.

    Melissa S Jurica;Andrew Mesecar;Patrick J Heath;Wuxian Shi

  • Computational design of ligand-binding proteins with high affinity and selectivity.

    Christine E. Tinberg;Sagar D. Khare;Jiayi Dou;Lindsey Doyle

  • Biocontainment of genetically modified organisms by synthetic protein design

    Daniel J. Mandell;Marc J. Lajoie;Michael T. Mee;Ryo Takeuchi

  • Computational Thermostabilization of an Enzyme

    Aaron Korkegian;Margaret E. Black;David Baker;Barry L. Stoddard

  • Computational redesign of endonuclease DNA binding and cleavage specificity.

    Justin Ashworth;James J. Havranek;Carlos M. Duarte;Django Sussman

  • Structure of the C2 domain of human factor VIII at 1.5 Å resolution

    Kathleen P. Pratt;Betty W. Shen;Kazuya Takeshima;Earl W. Davie

  • Accumulation of Free ADP-ribose from Mitochondria Mediates Oxidative Stress-induced Gating of TRPM2 Cation Channels

    Anne Laure Perraud;Christina L. Takanishi;Betty Shen;Shin Kang

  • Increased Diels-Alderase activity through backbone remodeling guided by Foldit players

    Christopher B Eiben;Justin B Siegel;Jacob B Bale;Seth Cooper

  • A synthetic sex ratio distortion system for the control of the human malaria mosquito

    Roberto Galizi;Lindsey A. Doyle;Miriam Menichelli;Federica Bernardini

  • Computational redesign of protein-protein interaction specificity.

    Tanja Kortemme;Lukasz A Joachimiak;Lukasz A Joachimiak;Alex N Bullock;Alex N Bullock;Aaron D Schuler

  • Homing endonucleases: from microbial genetic invaders to reagents for targeted DNA modification

    Barry L. Stoddard

  • A nomenclature for restriction enzymes, DNA methyl transferases, homing endonucleases and their genes

    RJ Roberts;M Belford;T Bester;AS Bhagwat

Frequent Co-Authors

David Baker
David Baker University of Washington
Raymond J. Monnat
Raymond J. Monnat University of Washington
Andrew M. Scharenberg
Andrew M. Scharenberg Seattle Children's Hospital
Adam J. Bogdanove
Adam J. Bogdanove Cornell University
Daniel E. Koshland
Daniel E. Koshland University of California, Berkeley
Geoffrey G. Wilson
Geoffrey G. Wilson New England Biolabs
Keith R. Fox
Keith R. Fox University of Southampton
Mark Groudine
Mark Groudine Fred Hutchinson Cancer Research Center
Harmit S. Malik
Harmit S. Malik Fred Hutchinson Cancer Research Center
Hans Peter Kiem
Hans Peter Kiem Fred Hutchinson Cancer Research Center

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

A background in molecular biology opens doors to many interdisciplinary careers. If you wish to expand your expertise or switch fields, exploring related online degree options can be a great choice.

For those interested in counseling, consider an online master's degree in counseling, which blends scientific understanding with interpersonal skills. Similarly, professionals curious about the intersection of biology and psychology may look into the best online clinical psychology programs to explore how mental and biological health connect.

If you're seeking a flexible and swift path into helping professions, human services online degree programs deliver relevant training for roles in social work, case management, and more.

Finally, molecular biology graduates or even teachers may consider a rewarding shift. If you're interested in a higher earning potential, our guide to career change for teachers higher pay highlights how roles such as speech-language pathologist bridge science, health, and education.

Best Scientists Citing Barry L. Stoddard

Trending Scientists

Recently Published Articles