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Molecular Biology

D-Index
71
Citations
20135
World Ranking
1371
National Ranking
695

Overview

Andrew M. Scharenberg is affiliated with Seattle Children's Hospital in the United States. Their research spans multiple fields including Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. The subfields of focus include Oncology, Immunology, Molecular Biology, Radiology, Nuclear Medicine and Imaging, and Genetics.

Their work primarily revolves around the following main topics:

  • CAR-T cell therapy research
  • Biosimilars and Bioanalytical Methods
  • Monoclonal and Polyclonal Antibodies Research
  • Virus-based gene therapy research
  • CRISPR and Genetic Engineering
  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology

Key recent publications include:

  • Gene editing to induce FOXP3 expression in human CD4 + T cells leads to a stable regulatory phenotype and function, 2020, Science Translational Medicine
  • Preclinical proof of concept for VivoVec, a lentiviral-based platform for in vivo CAR T-cell engineering, 2023, Journal for ImmunoTherapy of Cancer
  • Improved CRISPR genome editing using small highly active and specific engineered RNA-guided nucleases, 2021, Nature Communications
  • In vivo CAR T-cell generation in nonhuman primates using lentiviral vectors displaying a multidomain fusion ligand, 2024, Blood
  • A chemically inducible IL-2 receptor signaling complex allows for effective in vitro and in vivo selection of engineered CD4+ T cells, 2023, Molecular Therapy

Frequent co-authors collaborating with Andrew M. Scharenberg include:

  • Ryan Larson
  • Byoung Y. Ryu
  • Laurie Beitz
  • Kathryn Michels
  • Seungjin Shin

The scientist has published notably in venues such as Regular and Young Investigator Award Abstracts, Blood, Cancer Research, Nature Communications, and Science Translational Medicine.

Best Publications

  • LTRPC7 is a Mg·ATP-regulated divalent cation channel required for cell viability

    Monica J. S. Nadler;Meredith C. Hermosura;Kazunori Inabe;Anne-Laure Perraud

  • ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology

    Anne Laure Perraud;Andrea Fleig;Christopher A. Dunn;Leigh Ann Bagley

  • Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7.

    Carsten Schmitz;Anne-Laure Perraud;Catherine O Johnson;Kazunori Inabe

  • Multiplex Genome-Edited T-cell Manufacturing Platform for “Off-the-Shelf” Adoptive T-cell Immunotherapies

    Laurent Poirot;Brian Philip;Cécile Schiffer-Mannioui;Diane Le Clerre

  • TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization.

    Pierre Launay;Andrea Fleig;Anne Laure Perraud;Andrew M Scharenberg

  • A Unified Nomenclature for the Superfamily of TRP Cation Channels

    Craig Montell;Lutz Birnbaumer;Veit Flockerzi;René J. Bindels

  • TRPM7 provides an ion channel mechanism for cellular entry of trace metal ions.

    Mahealani K. Monteilh-Zoller;Meredith C. Hermosura;Monica J.S. Nadler;Andrew M. Scharenberg

  • Activation of BTK by a Phosphorylation Mechanism Initiated by SRC Family Kinases

    David J. Rawlings;Andrew M. Scharenberg;Hyunsun Park;Matthew I. Wahl

  • Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals

    Andrew M. Scharenberg;Ousama El-Hillal;David A. Fruman;Laurie O. Beitz

  • BTK/TEC KINASES REGULATE SUSTAINED INCREASES IN INTRACELLULAR CA2+ FOLLOWING B-CELL RECEPTOR ACTIVATION

    Anne Catherine Fluckiger;Zuomei Li;Roberta M. Kato;Matthew I. Wahl

  • Accumulation of Free ADP-ribose from Mitochondria Mediates Oxidative Stress-induced Gating of TRPM2 Cation Channels

    Anne Laure Perraud;Christina L. Takanishi;Betty Shen;Shin Kang

  • Tracking genome engineering outcome at individual DNA breakpoints

    Michael T. Certo;Byoung Y. Ryu;James E. Annis;Mikhail Garibov

  • BTK Regulates PtdIns-4,5-P2 Synthesis: Importance for Calcium Signaling and PI3K Activity

    Kan Saito;Kimberley F. Tolias;Abdelhafid Saci;Henry B. Koon

  • Calcium signalling and cell-fate choice in B cells

    Andrew M. Scharenberg;Lisa A. Humphries;David J. Rawlings

  • Receptor-mediated regulation of the TRPM7 channel through its endogenous protein kinase domain.

    Ryuichi Takezawa;Carsten Schmitz;Philippe Demeuse;Andrew M. Scharenberg

  • METHODS FOR ENGINEERING ALLOGENEIC AND IMMUNOSUPPRESSIVE RESISTANT T CELL

    Galetto Roman;Gouble Agnes;Grosse Stephanie;Schiffer-Mannioui Cecile

  • Efficient modification of CCR5 in primary human hematopoietic cells using a megaTAL nuclease and AAV donor template

    Blythe D. Sather;Guillermo S. Romano Ibarra;Karen Sommer;Gabrielle Curinga

  • SYK Is Upstream of Phosphoinositide 3-Kinase in B Cell Receptor Signaling

    Laurie O. Beitz;David A. Fruman;David A. Fruman;Tomohiro Kurosaki;Lewis C. Cantley;Lewis C. Cantley

  • TRPM2 Ca2+ permeable cation channels: from gene to biological function.

    Anne-Laure Perraud;Carsten Schmitz;Andrew M. Scharenberg

  • MegaTALs: A rare-cleaving nuclease architecture for therapeutic genome engineering

    Sandrine Boissel;Jordan Jarjour;Alexander Astrakhan;Andrew Adey

Frequent Co-Authors

David J. Rawlings
David J. Rawlings Seattle Children's Hospital
Troy R. Torgerson
Troy R. Torgerson Allen Institute
Hans Peter Kiem
Hans Peter Kiem Fred Hutchinson Cancer Research Center
Reinhold Penner
Reinhold Penner Queen's Medical Center
Andrea Fleig
Andrea Fleig University of Hawaii at Manoa
Barry L. Stoddard
Barry L. Stoddard Fred Hutchinson Cancer Research Center
Jean-Pierre Kinet
Jean-Pierre Kinet Beth Israel Deaconess Medical Center
Donald B. Kohn
Donald B. Kohn University of California, Los Angeles
Amalia Magaret
Amalia Magaret University of Washington
Raymond J. Monnat
Raymond J. Monnat University of Washington

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