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Biology and Biochemistry

D-Index
54
Citations
8813
World Ranking
15785
National Ranking
1238

Overview

Lin-Hua Jiang is affiliated with the University of Leeds in the United Kingdom. Their research spans several interconnected fields, focusing primarily on biochemistry, genetics, molecular biology, and medicine. The volume of their published work indicates a deep engagement with both foundational biological processes and their pathological implications.

Their main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these broad domains, Jiang's research emphasizes subfields such as molecular biology, physiology, sensory systems, and instrumentation. These subfields underpin their exploration of cellular mechanisms and signal transduction.

Key research topics covered by Jiang encompass:

  • Ion Channels and Receptors
  • Galaxies: Formation, Evolution, Phenomena
  • Astronomy and Astrophysical Research
  • Adenosine and Purinergic Signaling
  • Ion channel regulation and function
  • Astrophysical Phenomena and Observations
  • Neuroinflammation and Neurodegeneration Mechanisms

Jiang has contributed to numerous publications, including articles focused on molecular and cellular signaling pathways and their role in inflammatory and pathological processes. Some of the recent papers include:

  • Silica nanoparticles induce lung inflammation in mice via ROS/PARP/TRPM2 signaling-mediated lysosome impairment and autophagy dysfunction (2020) - Particle and Fibre Toxicology
  • TRPM2 channel-mediated cell death: An important mechanism linking oxidative stress-inducing pathological factors to associated pathological conditions (2020) - Redox Biology
  • Piezo1 channel-mediated Ca2+ signaling inhibits lipopolysaccharide-induced activation of the NF-κB inflammatory signaling pathway and generation of TNF-α and IL-6 in microglial cells (2022) - Glia
  • Structural basis for the functional properties of the P2X7 receptor for extracellular ATP (2021) - Purinergic Signalling
  • Exosomal circ_0088300 Derived From Cancer-Associated Fibroblasts Acts as a miR-1305 Sponge and Promotes Gastric Carcinoma Cell Tumorigenesis (2021) - Frontiers in Cell and Developmental Biology

Jiang collaborates frequently with several researchers, many of whom have coauthored multiple papers. Notable coauthors include:

  • Yizhou Yao
  • Wei Yang
  • Xuchao Wang
  • Xinguo Zhu
  • Sébastien Roger

The scientist's publications are disseminated through a variety of venues, with repeated contributions to:

  • arXiv (Cornell University)
  • Antioxidants
  • Frontiers in Oncology
  • Journal of Computing and Electronic Information Management
  • SSRN Electronic Journal

Lin-Hua Jiang's research covers complex cellular signaling pathways, ion channel function, and their relationship to inflammatory and degenerative mechanisms, positioning them at the intersection of biochemistry and molecular medicine.

Best Publications

  • Brilliant blue G selectively blocks ATP-gated rat P2X(7) receptors.

    Jiang Lh;Mackenzie Ab;North Ra;Surprenant A

  • Proteomic and functional evidence for a P2X7 receptor signalling complex

    Kim M;Jiang Lh;Wilson Hl;North Ra

  • A Luminous Quasar at Redshift 7.642

    Feige Wang;Jinyi Yang;Xiaohui Fan;Joseph F. Hennawi;Joseph F. Hennawi

  • TRPC channel activation by extracellular thioredoxin

    Shang Zhong Xu;Piruthivi Sukumar;Fanning Zeng;Jing Li

  • Identification of amino acid residues contributing to the ATP-binding site of a purinergic P2X receptor.

    Lin Hua Jiang;François Rassendren;Annmarie Surprenant;R. Alan North

  • Subunit arrangement in P2X receptors.

    Lin-Hua Jiang;Miran Kim;Valeria Spelta;Xuenong Bo

  • IONIZATION NEAR ZONES ASSOCIATED WITH QUASARS AT z ∼ 6 ∗

    C. L. Carilli;Ran Wang;Ran Wang;X. Fan;F. Walter

  • Pharmacological and biophysical properties of the human P2X5 receptor.

    Xuenong Bo;Lin Hua Jiang;Heather L. Wilson;Miran Kim

  • New structure enlivens interest in P2X receptors

    Liam E. Browne;Lin Hua Jiang;R. Alan North

  • Characterization of a selective and potent antagonist of human P2X7 receptors, AZ11645373

    Stokes L;Jiang Lh;Alcaraz L;Bent J

  • Anthraquinone emodin inhibits human cancer cell invasiveness by antagonizing P2X7 receptors.

    Bilel Jelassi;Monique Anchelin;Julie Chamouton;María Luisa Cayuela

  • A crucial role for hydrogen sulfide in oxygen sensing via modulating large conductance calcium-activated potassium channels.

    Qian Li;Biying Sun;Xiaofang Wang;Zhu Jin

  • Single nucleotide polymorphisms that were identified in affective mood disorders affect ATP-activated P2X7 receptor functions.

    Sébastien Roger;Zhu-Zhong Mei;Jocelyn M. Baldwin;Li Dong;Li Dong

  • Silica nanoparticles induce lung inflammation in mice via ROS/PARP/TRPM2 signaling-mediated lysosome impairment and autophagy dysfunction

    Mingxiang Wang;Jin Li;Shunni Dong;Xiaobo Cai

  • Amino Acid Residues Involved in Gating Identified in the First Membrane-spanning Domain of the Rat P2X2 Receptor

    Lin Hua Jiang;François Rassendren;François Rassendren;Valeria Spelta;Annmarie Surprenant

  • A Significantly Neutral Intergalactic Medium Around the Luminous z = 7 Quasar J0252–0503

    Feige Wang;Feige Wang;Frederick B. Davies;Frederick B. Davies;Jinyi Yang;Joseph F. Hennawi;Joseph F. Hennawi

  • N-methyl-D-glucamine and propidium dyes utilize different permeation pathways at rat P2X7 receptors

    Lin Hua Jiang;Francois Rassendren;Amanda Mackenzie;Yi Hong Zhang

  • Regulation of cloned cardiac L-type calcium channels by cGMP-dependent protein kinase.

    L. H. Jiang;D. J. Gawler;N. Hodson;C. J. Milligan

  • Insights into the Molecular Mechanisms Underlying Mammalian P2X7 Receptor Functions and Contributions in Diseases, Revealed by Structural Modeling and Single Nucleotide Polymorphisms.

    Lin-Hua Jiang;Jocelyn M. Baldwin;Sebastien Roger;Stephen A. Baldwin

  • Understanding the roles of the P2X7 receptor in solid tumour progression and therapeutic perspectives.

    Sébastien Roger;Bilel Jelassi;Isabelle Couillin;Pablo Pelegrin

Frequent Co-Authors

Wei Yang
Wei Yang South China University of Technology
Xiaohui Fan
Xiaohui Fan University of Arizona
David J. Beech
David J. Beech University of Leeds
Fabian Walter
Fabian Walter Max Planck Society
Jianhong Luo
Jianhong Luo Zhejiang University
Annmarie Surprenant
Annmarie Surprenant University of Sheffield
Joseph F. Hennawi
Joseph F. Hennawi University of California, Santa Barbara
Keith Horne
Keith Horne University of St Andrews
Bram Venemans
Bram Venemans Max Planck Society
Luis C. Ho
Luis C. Ho Peking University

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