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Microbiology

D-Index
44
Citations
9320
World Ranking
5103
National Ranking
1962

Overview

Jacek Skowronski is affiliated with Case Western Reserve University in the United States and focuses primarily on the fields of immunology and microbiology. Their research encompasses several key subfields including virology, immunology, molecular biology, and epidemiology.

The central topics covered in their work include HIV research and treatment, interferon and immune responses, ubiquitin and proteasome pathways, immune cell function and interaction, as well as cytomegalovirus and herpesvirus research.

Skowronski has contributed to scientific literature through publications in journals such as Nature Communications and Viruses. Recent papers include:

  • "Structure of HIV-1 Vpr in complex with the human nucleotide excision repair protein hHR23A," 2021, Nature Communications
  • "De Novo Expressed Vpr Stimulates HIV-1 Replication in T Cells," 2025, Viruses

Frequent collaborators in their research include In-Ja L. Byeon, Guillermo Calero, Ying Wu, Chang-Hyeock Byeon, and Jinwon Jung. Each of these coauthors has contributed alongside Skowronski in at least one publication.

Best Publications

  • Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

    Kasia Hrecka;Caili Hao;Magda Gierszewska;Selene K. Swanson

  • The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes

    Michael E. Greenberg;A.John Iafrate;Jacek Skowronski

  • Unit-length line-1 transcripts in human teratocarcinoma cells.

    Jacek Skowronski;T. G. Fanning;M. F. Singer

  • Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene.

    Jacek Skowronski;David Parks;Roberto Mariani

  • Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation

    Michael E. Greenberg;Scott Bronson;Martin Lock;Markus Neumann

  • A DILEUCINE MOTIF IN HIV-1 NEF IS ESSENTIAL FOR SORTING INTO CLATHRIN-COATED PITS AND FOR DOWNREGULATION OF CD4

    Michael Greenberg;Louis DeTulleo;Iris Rapoport;Jacek Skowronski

  • Mechanism for down-regulation of CD28 by Nef.

    Tomek Swigut;Nadim Shohdy;Jacek Skowronski

  • High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection.

    Roberto Mariani;Frank Kirchhoff;Frank Kirchhoff;Thomas C. Greenough;John L. Sullivan

  • Lentiviral Vpr usurps Cul4–DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle

    Kasia Hrecka;Magdalena Gierszewska;Smita Srivastava;Lukasz Kozaczkiewicz

  • Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection

    Smita Srivastava;Selene K. Swanson;Nicolas Manel;Laurence Florens

  • CD4 down-regulation by nef alleles isolated from human immunodeficiency virus type 1-infected individuals

    Roberto Mariani;Jacek Skowronski

  • Making sense out of LINES: long interspersed repeat sequences in mammalian genomes

    Maxine F. Singer;Jacek Skowronski

  • Defining the beginning and end of KpnI family segments.

    G. Grimaldi;J. Skowronski;M.F. Singer

  • Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling

    A. John Iafrate;Scott Bronson;Jacek Skowronski

  • HIV/Simian Immunodeficiency Virus (SIV) Accessory Virulence Factor Vpx Loads the Host Cell Restriction Factor SAMHD1 onto the E3 Ubiquitin Ligase Complex CRL4DCAF1

    Jinwoo Ahn;Caili Hao;Junpeng Yan;Maria DeLucia

  • Expression of a cytoplasmic LINE-1 transcript is regulated in a human teratocarcinoma cell line.

    Jacek Skowronski;Maxine F. Singer

  • Modulation of Different Human Immunodeficiency Virus Type 1 Nef Functions during Progression to AIDS

    Silke Carl;Thomas C. Greenough;Mandy Krumbiegel;Michael Greenberg

  • Gene expression during preimplantation mouse development.

    Jay L. Rothstein;Dabney Johnson;Julie A. DeLoia;Jacek Skowronski

  • Tetramerization of SAMHD1 Is Required for Biological Activity and Inhibition of HIV Infection

    Junpeng Yan;Sarabpreet Kaur;Maria DeLucia;Caili Hao

  • Mechanism of allosteric activation of SAMHD1 by dGTP

    Xiaoyun Ji;Ying Wu;Junpeng Yan;Jennifer Mehrens

Frequent Co-Authors

Frank Kirchhoff
Frank Kirchhoff University of Ulm
A. John Iafrate
A. John Iafrate Harvard University
Michael E. Greenberg
Michael E. Greenberg Harvard University
Michael P. Washburn
Michael P. Washburn University of Kansas
Selene K. Swanson
Selene K. Swanson Stowers Institute for Medical Research
Laurence Florens
Laurence Florens Stowers Institute for Medical Research
Angela M. Gronenborn
Angela M. Gronenborn University of Pittsburgh
Jan Münch
Jan Münch University of Ulm
Dietmar Fuchs
Dietmar Fuchs Innsbruck Medical University
Jonathan L. Heeney
Jonathan L. Heeney University of Cambridge

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