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Molecular Biology

D-Index
98
Citations
38200
World Ranking
570
National Ranking
312

Overview

Laurence Florens is affiliated with the Stowers Institute for Medical Research in the United States. Their research spans the field of Biochemistry, Genetics, and Molecular Biology, with a focus on Molecular Biology, Public Health, Environmental and Occupational Health, Cell Biology, Immunology, and Oncology.

The scientist's work covers several main topics, including:

  • RNA and protein synthesis mechanisms
  • RNA modifications and cancer
  • RNA Research and Splicing
  • Ubiquitin and proteasome pathways
  • Genomics and Chromatin Dynamics
  • Malaria Research and Control
  • DNA Repair Mechanisms

Laurence Florens has contributed to multiple scientific publications in prominent venues. Frequent publication outlets include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • eLife
  • Nature Communications
  • Cell Reports
  • Proceedings of the National Academy of Sciences

Some of the recent papers authored or co-authored by Laurence Florens are:

  • Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping, 2020, published in Nature
  • Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis, 2020, published in Nature Cell Biology
  • The methyltransferase SETD2 couples transcription and splicing by engaging mRNA processing factors through its SHI domain, 2021, published in Nature Communications
  • STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells, 2020, published in eLife
  • Distinct states of nucleolar stress induced by anticancer drugs, 2023, published in eLife

Laurence Florens frequently collaborates with other researchers. Notable co-authors include:

  • Michael P. Washburn
  • Jerry L. Workman
  • Charles A.S. Banks
  • Michaella J. Levy
  • Anita Saraf

Best Publications

  • A proteomic view of the Plasmodium falciparum life cycle

    Laurence Florens;Michael P. Washburn;J. Dale Raine;Robert M. Anthony

  • Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription.

    Michael J. Carrozza;Bing Li;Laurence Florens;Tamaki Suganuma

  • Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

    Kasia Hrecka;Caili Hao;Magda Gierszewska;Selene K. Swanson

  • Statistical analysis of membrane proteome expression changes in Saccharomyces cerevisiae.

    Boris Zybailov;Amber L. Mosley;Mihaela E. Sardiu;Michael K. Coleman

  • A Comprehensive Survey of the Plasmodium Life Cycle by Genomic, Transcriptomic, and Proteomic Analyses

    Neil Hall;Marianna Karras;J. Dale Raine;Jane M. Carlton;Jane M. Carlton;Jane M. Carlton

  • Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii

    Jane M. Carlton;Samuel V. Angiuoli;Bernard B. Suh;Taco W. Kooij

  • Acetylation by Tip60 Is Required for Selective Histone Variant Exchange at DNA Lesions

    Thomas Kusch;Laurence Florens;W. Hayes MacDonald;Selene K. Swanson

  • Nuclear Membrane Proteins with Potential Disease Links Found by Subtractive Proteomics

    Eric C. Schirmer;Laurence Florens;Tinglu Guan;John R. Yates

  • Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast.

    Norman Pavelka;Giulia Rancati;Jin Zhu;William D. Bradford

  • AFF4, a Component of the ELL/P-TEFb Elongation Complex and a Shared Subunit of MLL Chimeras, Can Link Transcription Elongation to Leukemia

    Chengqi Lin;Edwin R. Smith;Hidehisa Takahashi;Ka Chun Lai

  • Quantitative proteomic analysis of distinct mammalian Mediator complexes using normalized spectral abundance factors.

    Andrew C. Paoletti;Tari J. Parmely;Chieri Tomomori-Sato;Shigeo Sato

  • Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle

    Karine G. Le Roch;Jeffrey R. Johnson;Laurence Florens;Yingyao Zhou

  • Histone Crosstalk between H2B Monoubiquitination and H3 Methylation Mediated by COMPASS

    Jung Shin Lee;Abhijit Shukla;Jessica Schneider;Selene K. Swanson

  • Cytosolic proteostasis through importing of misfolded proteins into mitochondria

    Linhao Ruan;Chuankai Zhou;Erli Jin;Andrei Kucharavy;Andrei Kucharavy

  • Refinements to label free proteome quantitation: how to deal with peptides shared by multiple proteins.

    Ying Zhang;Zhihui Wen;Michael P. Washburn;Laurence Florens

  • Evolutionarily Conserved Multisubunit RBL2/p130 and E2F4 Protein Complex Represses Human Cell Cycle-Dependent Genes in Quiescence

    Larisa Litovchick;Subhashini Sadasivam;Laurence Florens;Xiaopeng Zhu

  • Correlation of Relative Abundance Ratios Derived from Peptide Ion Chromatograms and Spectrum Counting for Quantitative Proteomic Analysis Using Stable Isotope Labeling

    Boris Zybailov;Michael K. Coleman;and Laurence Florens;Michael P. Washburn

  • Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler.

    Aaron J. Gottschalk;Gyula Timinszky;Stephanie E. Kong;Jingji Jin

  • Cyclin F-Mediated Degradation of Ribonucleotide Reductase M2 Controls Genome Integrity and DNA Repair

    Vincenzo D'Angiolella;Valerio Donato;Frances M. Forrester;Yeon-Tae Jeong

  • Analyzing chromatin remodeling complexes using shotgun proteomics and normalized spectral abundance factors

    Laurence Florens;Michael J Carozza;Selene K Swanson;Marjorie Fournier

Frequent Co-Authors

Michael P. Washburn
Michael P. Washburn University of Kansas
Selene K. Swanson
Selene K. Swanson Stowers Institute for Medical Research
Joan Weliky Conaway
Joan Weliky Conaway The University of Texas Southwestern Medical Center
Jerry L. Workman
Jerry L. Workman Stowers Institute for Medical Research
Ronald C. Conaway
Ronald C. Conaway The University of Texas Southwestern Medical Center
John R. Yates
John R. Yates Scripps Research Institute
Susan M. Abmayr
Susan M. Abmayr Stowers Institute for Medical Research
Ali Shilatifard
Ali Shilatifard Northwestern University
Michele Pagano
Michele Pagano New York University
James A. DeCaprio
James A. DeCaprio Harvard University

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