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Molecular Biology

D-Index
95
Citations
32368
World Ranking
634
National Ranking
346

Research.com Recognitions

  • 2002 - Fellow of the American Academy of Arts and Sciences

Overview

Ronald C. Conaway is affiliated with the Stowers Institute for Medical Research in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with a notable emphasis on molecular biology as a subfield. The scientist's work spans additional subfields including genetics, cell biology, electrical and electronic engineering, and oncology.

Their main topics of research include RNA research and splicing, genomics and chromatin dynamics, RNA modifications and cancer, genetics and neurodevelopmental disorders, endoplasmic reticulum stress and disease, RNA and protein synthesis mechanisms, and PARP inhibition in cancer therapy.

Ronald C. Conaway's body of published work has appeared in a variety of scientific venues. Frequent publication locations include:

  • The FASEB Journal
  • Nature Communications
  • Proceedings of the National Academy of Sciences
  • Cell
  • Cell Reports

Their recent papers illustrate an active engagement in topics related to RNA polymerase II and its regulation as well as protein degradation pathways relevant to disease mechanisms. Selected recent publications include:

  • "Regulation of the RNAPII Pool Is Integral to the DNA Damage Response," 2020, Cell
  • "NRBP1-Containing CRL2/CRL4A Regulates Amyloid β Production by Targeting BRI2 and BRI3 for Degradation," 2020, Cell Reports
  • "The role of Mediator and Little Elongation Complex in transcription termination," 2020, Nature Communications
  • "The 3' Pol II pausing at replication-dependent histone genes is regulated by Mediator through Cajal bodies' association with histone locus bodies," 2022, Nature Communications
  • "UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1," 2022, DNA Repair

Collaboration is a significant aspect of their scholarly activity. Frequent coauthors include Joan Conaway, Shigeo Sato, Chieri Tomomori-Sato, Juston C. Weems, and Michael P. Washburn, reflecting ongoing partnerships in related fields of study.

Ronald C. Conaway was recognized as a Fellow of the American Academy of Arts and Sciences in 2002.

Best Publications

  • Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase.

    T. Kamura;D. M. Koepp;D. M. Koepp;M. N. Conrad;D. Skowyra

  • Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex.

    Takumi Kamura;Shigeo Sato;Kazuhiro Iwai;Maria Czyzyk-Krzeska

  • The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

    Takumi Kamura;Shigeo Sato;Dewan Haque;Li Liu

  • Inhibition of transcription elongation by the VHL tumor suppressor protein

    D. R. Duan;A. Pause;W. H. Burgess;T. Aso

  • Identification of the von Hippel–Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

    Kazuhiro Iwai;Koji Yamanaka;Takumi Kamura;Nagahiro Minato

  • Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex

    Emmanuelle Querido;Paola Blanchette;Qin Yan;Takumi Kamura

  • AFF4, a Component of the ELL/P-TEFb Elongation Complex and a Shared Subunit of MLL Chimeras, Can Link Transcription Elongation to Leukemia

    Chengqi Lin;Edwin R. Smith;Hidehisa Takahashi;Ka Chun Lai

  • Quantitative proteomic analysis of distinct mammalian Mediator complexes using normalized spectral abundance factors.

    Andrew C. Paoletti;Tari J. Parmely;Chieri Tomomori-Sato;Shigeo Sato

  • General Initiation Factors for RNA Polymerase II

    Ronald C. Conaway;Joan Weliky Conaway

  • VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

    Takumi Kamura;Katsumi Maenaka;Shuhei Kotoshiba;Masaki Matsumoto

  • Regulation of Hypoxia-Inducible mRNAs by the von Hippel-Lindau Tumor Suppressor Protein Requires Binding to Complexes Containing Elongins B/C and Cul2

    Kim M. Lonergan;Othon Iliopoulos;Othon Iliopoulos;Michael Ohh;Michael Ohh;Takumi Kamura

  • Association of Cdk-activating kinase subunits with transcription factor TFIIH

    Hiroaki Serizawa;Tomi P. Mäkelä;Joan Weliky Conaway;Ronald C. Conaway

  • Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II.

    Teijiro Aso;William S. Lane;Joan Weliky Conaway;Ronald C. Conaway

  • Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways

    Yi Wei Jiang;Philippe Veschambre;Hediye Erdjument-Bromage;Paul Tempst

  • An RNA Polymerase II Elongation Factor Encoded by the Human ELL Gene

    Ali Shilatifard;William S. Lane;Kenneth W. Jackson;Ronald C. Conaway

  • Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler.

    Aaron J. Gottschalk;Gyula Timinszky;Stephanie E. Kong;Jingji Jin

  • Function and regulation of the Mediator complex.

    Ronald C Conaway;Joan Weliky Conaway;Joan Weliky Conaway

  • Multiple Splice Variants of the Human HIF-3α Locus Are Targets of the von Hippel-Lindau E3 Ubiquitin Ligase Complex

    Mindy A. Maynard;Heng Qi;Jacky Chung;Eric H.L. Lee

  • Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1

    Tingting Yao;Ling Song;Wei Xu;George N. DeMartino

  • Human Mediator Subunit Med26 Functions As A Docking Site For Transcription Elongation Factors

    Hidehisa Takahashi;Tari J. Parmely;Shigeo Sato;Chieri Tomomori-Sato

Frequent Co-Authors

Joan Weliky Conaway
Joan Weliky Conaway The University of Texas Southwestern Medical Center
Michael P. Washburn
Michael P. Washburn University of Kansas
Laurence Florens
Laurence Florens Stowers Institute for Medical Research
Ali Shilatifard
Ali Shilatifard Northwestern University
Selene K. Swanson
Selene K. Swanson Stowers Institute for Medical Research
Qin Yan
Qin Yan Yale University
Lu Chen
Lu Chen Stanford University
William G. Kaelin
William G. Kaelin Harvard University
William S. Lane
William S. Lane Harvard University
Jesper Q. Svejstrup
Jesper Q. Svejstrup University of Copenhagen

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