World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
19047
World Ranking
13559
National Ranking
470

Overview

Michael Ohh is affiliated with the University of Toronto in Canada. Their research spans multiple domains within biochemistry, genetics, molecular biology, and medicine, with a strong focus on cancer biology and related molecular mechanisms.

Their main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these broader fields, Michael Ohh's subfields of study comprise:

  • Molecular Biology
  • Cancer Research
  • Oncology
  • Surgery
  • Immunology

The primary topics in Michael Ohh's work include:

  • Cancer, Hypoxia, and Metabolism
  • Protein Tyrosine Phosphatases
  • Adrenal and Paraganglionic Tumors
  • Protein Kinase Regulation and GTPase Signaling
  • Mitochondrial Function and Pathology
  • Ubiquitin and proteasome pathways
  • RNA modifications and cancer

The scientist has contributed to a number of recent publications, notable examples include:

  • Nucleolar RNA polymerase II drives ribosome biogenesis, 2020, Nature
  • PD-1 blockade delays tumor growth by inhibiting an intrinsic SHP2/Ras/MAPK signalling in thyroid cancer cells, 2021, Journal of Experimental & Clinical Cancer Research
  • NRAS Status Determines Sensitivity to SHP2 Inhibitor Combination Therapies Targeting the RAS-MAPK Pathway in Neuroblastoma, 2020, Cancer Research
  • The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors, 2021, Nature Communications
  • Hypoxia and viral infectious diseases, 2021, JCI Insight

Michael Ohh frequently collaborates with several co-authors, including:

  • Yoshihito Kano
  • Mitsuhiko Ikura
  • Fraser G. Ferens
  • Jeffrey E. Lee
  • Meredith S. Irwin

Their work has appeared repeatedly in several publication venues, with multiple contributions to:

  • eLife
  • Journal of Molecular Biology
  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • UNC Libraries

Best Publications

  • HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O2 Sensing

    Mircea Ivan;Keiichi Kondo;Haifeng Yang;William Y. Kim

  • Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein

    Michael Ohh;Cheol Won Park;Cheol Won Park;Mircea Ivan;Michael A. Hoffman

  • The updated biology of hypoxia‐inducible factor

    Samantha N Greer;Julie L Metcalf;Yi Wang;Michael Ohh

  • The von Hippel-Lindau Tumor Suppressor Protein Is Required for Proper Assembly of an Extracellular Fibronectin Matrix

    Michael Ohh;Robert L. Yauch;Kim M. Lonergan;Jean M. Whaley

  • Regulation of Hypoxia-Inducible mRNAs by the von Hippel-Lindau Tumor Suppressor Protein Requires Binding to Complexes Containing Elongins B/C and Cul2

    Kim M. Lonergan;Othon Iliopoulos;Othon Iliopoulos;Michael Ohh;Michael Ohh;Takumi Kamura

  • von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF

    Michael A. Hoffman;Michael Ohh;Haifeng Yang;Jeff M. Klco

  • Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia

    Charlotte M. Niemeyer;Michelle W. Kang;Danielle H. Shin;Ingrid Furlan

  • Multiple Splice Variants of the Human HIF-3α Locus Are Targets of the von Hippel-Lindau E3 Ubiquitin Ligase Complex

    Mindy A. Maynard;Heng Qi;Jacky Chung;Eric H.L. Lee

  • Differential Dependence of Hypoxia-inducible Factors 1α and 2α on mTORC1 and mTORC2

    Alfredo Toschi;Evan Lee;Noga Gadir;Michael Ohh

  • pVHL19 is a biologically active product of the von Hippel–Lindau gene arising from internal translation initiation

    Othon Iliopoulos;Michael Ohh;William G. Kaelin

  • VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail

    Andrew J. Evans;Ryan C. Russell;Olga Roche;T. Nadine Burry

  • Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression

    Rónán C. O'Hagan;Michael Ohh;Gregory David;Ignacio Moreno de Alboran

  • pVHL Modification by NEDD8 Is Required for Fibronectin Matrix Assembly and Suppression of Tumor Development

    Natalie H. Stickle;Jacky Chung;Jeffery M. Klco;Richard P. Hill

  • Human HIF-3α4 is a dominant-negative regulator of HIF-1 and is down-regulated in renal cell carcinoma

    Mindy A. Maynard;Andrew J. Evans;Andrew J. Evans;Tomoko Hosomi;Shuntaro Hara

  • Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis

    Severa Bunda;Kelly Burrell;Pardeep Heir;Lifan Zeng

  • Regulation of endocytosis via the oxygen-sensing pathway

    Yi Wang;Olga Roche;Mathew S Yan;Greg Finak

  • An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells

    Michael Ohh;William Y Kim;Javid J Moslehi;Yuzhi Chen

  • NEDD8 pathways in cancer, Sine Quibus Non.

    Ian R. Watson;Meredith S. Irwin;Michael Ohh

  • Functional Importance of Dicer Protein in the Adaptive Cellular Response to Hypoxia

    J.J.David Ho;Julie L. Metcalf;Matthew S. Yan;Paul J. Turgeon

  • Hypoxia-inducible expression of a natural cis-antisense transcript inhibits endothelial nitric-oxide synthase.

    Jason E. Fish;Charles C. Matouk;Elizabeth Yeboah;Sian C. Bevan

Frequent Co-Authors

William G. Kaelin
William G. Kaelin Harvard University
Bin Tean Teh
Bin Tean Teh National University of Singapore
Mitsuhiko Ikura
Mitsuhiko Ikura Princess Margaret Cancer Centre
Zhong Yin Zhang
Zhong Yin Zhang Purdue University West Lafayette
David A. Foster
David A. Foster City University of New York
Julie St-Pierre
Julie St-Pierre McGill University
Ming-Sound Tsao
Ming-Sound Tsao Princess Margaret Cancer Centre
Michael A.S. Jewett
Michael A.S. Jewett University of Toronto
Yi Wang
Yi Wang Cornell University
Brian Raught
Brian Raught Princess Margaret Cancer Centre

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