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D-Index & Metrics

Biology and Biochemistry

D-Index
128
Citations
77981
World Ranking
438
National Ranking
280

Medicine

D-Index
128
Citations
78063
World Ranking
2662
National Ranking
1486

Research.com Recognitions

  • 2015 - Member of the National Academy of Medicine (NAM)

Overview

Amato J. Giaccia is affiliated with Stanford University in the United States and has an extensive research profile primarily focused on biochemistry, genetics, molecular biology, and medicine. Their work spans multiple interconnected fields, including molecular biology, immunology, cancer research, pulmonary and respiratory medicine, and oncology.

The primary topics of Giaccia's research encompass:

  • Cancer, Hypoxia, and Metabolism
  • Radiation Therapy and Dosimetry
  • Immune Cell Function and Interaction
  • Immunotherapy and Immune Responses
  • Cancer Immunotherapy and Biomarkers
  • Ferroptosis and cancer prognosis
  • RNA Research and Splicing

Giaccia has contributed to numerous scientific papers, several of which have received attention in prominent journals. Notable recent publications include:

  • "Mitochondrial copper depletion suppresses triple-negative breast cancer in mice," 2020, Nature Biotechnology
  • "Irradiation at Ultra-High (FLASH) Dose Rates Reduces Acute Normal Tissue Toxicity in the Mouse Gastrointestinal System," 2021, International Journal of Radiation Oncology*Biology*Physics
  • "The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling," 2021, Nature Communications
  • "ACSL3 regulates lipid droplet biogenesis and ferroptosis sensitivity in clear cell renal cell carcinoma," 2022, Cancer & Metabolism
  • "The m 6 A RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor," 2020, Proceedings of the National Academy of Sciences

Frequent collaborators in Giaccia's research include:

  • Eui Jung Moon
  • Quynh-Thu Le
  • Erinn B. Rankin
  • Yu Rebecca Miao
  • Edward L. LaGory

Giaccia's research has been published repeatedly in several key venues such as bioRxiv (Cold Spring Harbor Laboratory), the International Journal of Radiation Oncology*Biology*Physics, the Journal of Clinical Investigation, Proceedings of the National Academy of Sciences, and Cell Death and Disease.

In 2015, Giaccia was recognized as a member of the National Academy of Medicine (NAM).

Best Publications

  • Radiobiology for the radiologist

    Eric J. Hall;Amato J. Giaccia

  • Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

    Kandice R. Levental;Hongmei Yu;Laura Kass;Johnathon N. Lakins

  • Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

    Thomas G. Graeber;Cynthia Osmanian;Tyler Jacks;David E. Housman

  • The unique physiology of solid tumors: opportunities (and problems) for cancer therapy

    J M Brown;A J Giaccia

  • The complexity of p53 modulation: emerging patterns from divergent signals

    Amato J. Giaccia;Michael B. Kastan

  • Retraction Note: Lysyl oxidase is essential for hypoxia-induced metastasis

    Janine T. Erler;Kevin L. Bennewith;Monica Nicolau;Nadja Dornhöfer

  • Pre-metastatic niches: organ-specific homes for metastases

    Héctor Peinado;Haiying Zhang;Irina R. Matei;Bruno Costa-Silva

  • Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin

    Christine C. Hudson;Mei Liu;Gary G. Chiang;Diane M. Otterness

  • Hypoxic control of metastasis.

    Erinn B. Rankin;Amato J. Giaccia

  • Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche

    Janine T. Erler;Kevin L. Bennewith;Kevin L. Bennewith;Thomas R. Cox;Georgina Lang

  • Loss of PTEN facilitates HIF-1-mediated gene expression

    Wayne Zundel;Cornelia Schindler;Daphne Haas-Kogan;Albert Koong

  • The role of hypoxia-inducible factors in tumorigenesis.

    E B Rankin;A J Giaccia

  • Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.

    M S Soengas;R M Alarcón;H Yoshida;A J Giaccia

  • Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

    T G Graeber;J F Peterson;M Tsai;K Monica

  • JunD Reduces Tumor Angiogenesis by Protecting Cells from Oxidative Stress

    Damien Gerald;Edurne Berra;Yves M. Frapart;Denise A. Chan

  • HIF-1 as a target for drug development.

    Amato Giaccia;Bronwyn G. Siim;Randall S. Johnson

  • Gene Expression Programs in Response to Hypoxia: Cell Type Specificity and Prognostic Significance in Human Cancers

    Jen Tsan Chi;Jen Tsan Chi;Zhen Wang;Dimitry S.A. Nuyten;Edwin H. Rodriguez

  • Radiation oncology: a century of achievements.

    Jacques Bernier;Eric J. Hall;Amato Giaccia

  • Induction of Vascular Endothelial Growth Factor by Hypoxia Is Modulated by a Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Ha-ras-Transformed Cells Through a Hypoxia Inducible Factor-1 Transcriptional Element

    Nathalie M. Mazure;Eunice Y. Chen;Eunice Y. Chen;Keith R. Laderoute;Keith R. Laderoute;Amato J. Giaccia;Amato J. Giaccia

  • Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy

    Jeffrey M. Arbeit;J. Martin Brown;K. S.Clifford Chao;J. Donald Chapman

Frequent Co-Authors

Albert C. Koong
Albert C. Koong The University of Texas MD Anderson Cancer Center
Quynh-Thu Le
Quynh-Thu Le Stanford University
Janine T. Erler
Janine T. Erler University of Copenhagen
Ester M. Hammond
Ester M. Hammond University of Oxford
Michael T. Longaker
Michael T. Longaker Stanford University
Ernestina Schipani
Ernestina Schipani University of Michigan–Ann Arbor
Julia Brown
Julia Brown University of Leeds
Geoffrey C. Gurtner
Geoffrey C. Gurtner Stanford University
J. Martin Brown
J. Martin Brown Stanford University
Constantinos Koumenis
Constantinos Koumenis University of Pennsylvania

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