2023 - Research.com Biology and Biochemistry in Australia Leader Award
His main research concerns Receptor, Allosteric regulation, G protein-coupled receptor, Functional selectivity and Cell biology. His Receptor study combines topics in areas such as Endocrinology, Signal transduction and Pharmacology. His Allosteric regulation study incorporates themes from Biophysics, Muscarinic acetylcholine receptor and Stereochemistry.
His G protein-coupled receptor study is concerned with Biochemistry in general. His research in Functional selectivity intersects with topics in Ligand, Drug action and Calcium signaling. He interconnects RAMP1, Glucagon-like peptide 1 receptor, Transmembrane domain and Receptor Activity-Modifying Protein 1 in the investigation of issues within Cell biology.
Receptor, G protein-coupled receptor, Allosteric regulation, Biochemistry and Cell biology are his primary areas of study. Patrick M. Sexton combines subjects such as Signal transduction and Pharmacology with his study of Receptor. His G protein-coupled receptor research is multidisciplinary, incorporating perspectives in Binding site, G protein, Computational biology, Peptide and Drug discovery.
His study in Allosteric regulation is interdisciplinary in nature, drawing from both Biophysics, Muscarinic acetylcholine receptor, Stereochemistry and Cooperativity. His Biophysics research includes elements of Structural biology and Gs alpha subunit. His Cell biology research includes themes of Receptor activity-modifying protein and Transmembrane domain.
The scientist’s investigation covers issues in Receptor, G protein-coupled receptor, Cell biology, Agonist and Biophysics. His Receptor course of study focuses on Peptide and Corticotropin-releasing hormone receptor 1. His G protein-coupled receptor study integrates concerns from other disciplines, such as Calcitonin, Calcitonin receptor, Structural biology, Computational biology and Drug discovery.
The various areas that Patrick M. Sexton examines in his Cell biology study include RAMP1, Transmembrane protein, Transmembrane domain and Receptor Activity-Modifying Protein 1. His Agonist study combines topics from a wide range of disciplines, such as Extracellular, Pharmacology, Function and Ligand. He studied Biophysics and Glucagon-like peptide 1 receptor that intersect with Receptor complex.
Patrick M. Sexton spends much of his time researching Receptor, G protein-coupled receptor, G protein, Cell biology and Glucagon-like peptide 1 receptor. His study in Functional selectivity and Agonist are all subfields of Receptor. The concepts of his G protein-coupled receptor study are interwoven with issues in Structural biology, Computational biology, Drug discovery and Insulin resistance.
The Cell biology study combines topics in areas such as RAMP1 and Receptor Activity-Modifying Protein 1. His Glucagon-like peptide 1 receptor research is multidisciplinary, incorporating perspectives in Biophysics, Transmembrane domain and Receptor complex. His Receptor complex study deals with Protein domain intersecting with Allosteric regulation.
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Functional Selectivity and Classical Concepts of Quantitative Pharmacology
Jonathan D. Urban;William P. Clarke;Mark Von Zastrow;David E. Nichols.
Journal of Pharmacology and Experimental Therapeutics (2007)
International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors.
David R. Poyner;Patrick M. Sexton;Ian Marshall;David M. Smith.
Pharmacological Reviews (2002)
Activation and allosteric modulation of a muscarinic acetylcholine receptor
Andrew C. Kruse;Aaron M. Ring;Aashish Manglik;Jianxin Hu.
Allosteric modulation of G protein-coupled receptors.
Lauren T May;Katie Leach;Patrick M Sexton;Arthur Christopoulos.
Annual Review of Pharmacology and Toxicology (2007)
Abundant calcitonin receptors in isolated rat osteoclasts. Biochemical and autoradiographic characterization.
G.C. Nicholson;J.M. Moseley;P.M. Sexton;F.A.O. Mendelsohn.
Journal of Clinical Investigation (1986)
G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor
Evi Kostenis;Graeme Milligan;Arthur Christopoulos;Carlos F. Sanchez-Ferrer.
Multiple Amylin Receptors Arise from Receptor Activity- Modifying Protein Interaction with the Calcitonin Receptor Gene Product
George Christopoulos;Katie J. Perry;Maria Morfis;Nanda Tilakaratne.
Molecular Pharmacology (1999)
Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs
Ron O. Dror;Hillary F. Green;Celine Valant;David W. Borhani.
Emerging paradigms in GPCR allostery: implications for drug discovery
Denise Laura Wootten;Arthur Christopoulos;Patrick Sexton.
Nature Reviews Drug Discovery (2013)
Mechanisms of signalling and biased agonism in G protein-coupled receptors
Denise L Wootten;Arthur Christopoulos;Maria Marti-Solano;M. Madan Babu.
Nature Reviews Molecular Cell Biology (2018)
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