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Colleen M. Niswender

Colleen M. Niswender

D-Index & Metrics

Neuroscience

D-Index
59
Citations
14575
World Ranking
3966
National Ranking
1802

Overview

Colleen M. Niswender is affiliated with Vanderbilt University in the United States. Their research spans key areas within biochemistry, genetics, molecular biology, and neuroscience, focusing particularly on cellular and molecular mechanisms related to neuropharmacology and neurodevelopmental disorders.

The main fields of study for Niswender include:

  • Biochemistry, Genetics and Molecular Biology
  • Neuroscience

Within these broader fields, their notable subfields of research address:

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Genetics
  • Cognitive Neuroscience
  • Pharmacology

The principal topics covered in their body of work are:

  • Neuroscience and Neuropharmacology Research
  • Receptor Mechanisms and Signaling
  • Genetics and Neurodevelopmental Disorders
  • Nicotinic Acetylcholine Receptors Study
  • Photoreceptor and optogenetics research
  • RNA regulation and disease
  • Pharmacological Receptor Mechanisms and Effects

Among recent publications by Niswender are:

  • Activating mGlu3 Metabotropic Glutamate Receptors Rescues Schizophrenia-like Cognitive Deficits Through Metaplastic Adaptations Within the Hippocampus (2021, Biological Psychiatry)
  • mGlu1 potentiation enhances prelimbic somatostatin interneuron activity to rescue schizophrenia-like physiological and cognitive deficits (2021, Cell Reports)
  • Phenotypic profiling of mGlu7 knockout mice reveals new implications for neurodevelopmental disorders (2020, Genes Brain & Behavior)
  • A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes (2021, JCI Insight)
  • Input-specific regulation of glutamatergic synaptic transmission in the medial prefrontal cortex by mGlu 2 /mGlu 4 receptor heterodimers (2021, Science Signaling)

Frequent publication venues include:

  • Bioorganic & Medicinal Chemistry Letters
  • ACS Chemical Neuroscience
  • Journal of Pharmacology and Experimental Therapeutics
  • ACS Medicinal Chemistry Letters
  • The FASEB Journal

Collaborations appear significant in Niswender's research, with frequent co-authors being:

  • Craig W. Lindsley
  • P. Jeffrey Conn
  • Alice L. Rodriguez
  • Sichen Chang
  • Olivier Boutaud

Best Publications

  • Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

    Colleen M. Niswender;P. Jeffrey Conn

  • Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator

    Huixian Wu;Chong Wang;Karen J. Gregory;Karen J. Gregory;Gye Won Han

  • RNA EDITING OF THE HUMAN SEROTONIN 5-HYDROXYTRYPTAMINE 2C RECEPTOR SILENCES CONSTITUTIVE ACTIVITY

    Colleen M. Niswender;Sara C. Copeland;Katharine Herrick-Davis;Ronald B. Emeson

  • Glutamate receptors as therapeutic targets for Parkinson's disease.

    Kari A. Johnson;P. Jeffrey Conn;Colleen M. Niswender

  • RNA editing of the human serotonin 5-HT2C receptor. alterations in suicide and implications for serotonergic pharmacotherapy.

    Colleen M Niswender;Colleen M Niswender;Katherine Herrick-Davis;Ginney E Dilley;Herbert Y Meltzer

  • Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders

    P. Jeffrey Conn;Craig W. Lindsley;Jens Meiler;Colleen M. Niswender

  • Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery.

    Bruce J. Melancon;Corey R. Hopkins;Michael R. Wood;Kyle A. Emmitte

  • Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity.

    Alice L. Rodriguez;Mark D. Grier;Carrie K. Jones;Elizabeth J. Herman

  • Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4.

    Colleen M. Niswender;Kari A. Johnson;C. David Weaver;Carrie K. Jones

  • Serotonin 5-HT2C receptor RNA editing alters receptor basal activity: implications for serotonergic signal transduction.

    Katharine Herrick-Davis;Ellinor Grinde;Colleen M. Niswender

  • Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors

    Craig W. Lindsley;Kyle A. Emmitte;Corey R. Hopkins;Thomas M. Bridges

  • An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission.

    Jana K Shirey;Zixiu Xiang;Darren Orton;Ashley E Brady

  • Functional Impact of Allosteric Agonist Activity of Selective Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 in Regulating Central Nervous System Function

    Meredith J. Noetzel;Jerri M. Rook;Paige N. Vinson;Hyekyung P. Cho

  • Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity.

    Joy E. Marlo;Colleen M. Niswender;Emily L. Days;Thomas M. Bridges

  • RNA-editing of the 5-HT(2C) receptor alters agonist-receptor-effector coupling specificity.

    Kelly A Berg;Jodie D Cropper;Colleen M Niswender;Elaine Sanders-Bush

  • ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice.

    Kristian Kaufmann;Ian Romaine;Emily Days;Conrado Pascual

  • Selective Activation of M4 Muscarinic Acetylcholine Receptors Reverses MK-801-Induced Behavioral Impairments and Enhances Associative Learning in Rodents

    Michael Bubser;Thomas M Bridges;Thomas M Bridges;Ditte Dencker;Robert W Gould

  • Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release

    Daniel J. Foster;Jermaine M. Wilson;Daniel H. Remke;M. Suhaib Mahmood

  • A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning.

    Douglas J. Sheffler;Richard Williams;Thomas M. Bridges;Zixiu Xiang

  • Selective Actions of Novel Allosteric Modulators Reveal Functional Heteromers of Metabotropic Glutamate Receptors in the CNS

    Shen Yin;Meredith J Noetzel;Kari A Johnson;Rocio Zamorano

  • The Metabotropic Glutamate Receptor 4-Positive Allosteric Modulator VU0364770 Produces Efficacy Alone and in Combination with l-DOPA or an Adenosine 2A Antagonist in Preclinical Rodent Models of Parkinson's Disease

    Carrie K. Jones;Michael Bubser;Analisa D. Thompson;Jonathan W. Dickerson

  • A Novel Assay of Gi/o-Linked G Protein-Coupled Receptor Coupling to Potassium Channels Provides New Insights into the Pharmacology of the Group III Metabotropic Glutamate Receptors

    Colleen M. Niswender;Kari A. Johnson;Qingwei Luo;Jennifer E. Ayala

Frequent Co-Authors

Carrie K. Jones
Carrie K. Jones Vanderbilt University
Michael Bubser
Michael Bubser Vanderbilt University
Nicholas J. Brandon
Nicholas J. Brandon Neumora Therapeutics Inc
Elaine Sanders-Bush
Elaine Sanders-Bush Vanderbilt University
Gilles Tamagnan
Gilles Tamagnan Yale University
Francesco Ferraguti
Francesco Ferraguti Innsbruck Medical University

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