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Chemistry

D-Index
40
Citations
5364
World Ranking
17918
National Ranking
4369

Overview

C. David Weaver is a researcher affiliated with Vanderbilt University in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with notable contributions to medicine. Key subfields of their work include molecular biology, cellular and molecular neuroscience, organic chemistry, psychiatry and mental health, and pharmacology.

The researcher's main topics of investigation encompass ion channel regulation and function, neuroscience and neuropharmacology research, receptor mechanisms and signaling, epilepsy research and treatment, cardiac electrophysiology and arrhythmias, neuropeptides and animal physiology, as well as cannabis and cannabinoid research.

C. David Weaver has contributed to several scientific publications. Some of their recent papers include:

  • Next-generation inward rectifier potassium channel modulators: discovery and molecular pharmacology, 2021, American Journal of Physiology-Cell Physiology
  • VU0606170, a Selective Slack Channels Inhibitor, Decreases Calcium Oscillations in Cultured Cortical Neurons, 2020, ACS Chemical Neuroscience
  • A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function, 2023, Proceedings of the National Academy of Sciences
  • Highly Selective Y4 Receptor Antagonist Binds in an Allosteric Binding Pocket, 2021, Journal of Medicinal Chemistry
  • Symmetrically substituted dichlorophenes inhibit N-acyl-phosphatidylethanolamine phospholipase D, 2020, Journal of Biological Chemistry

The professional collaborations of C. David Weaver include frequent co-authors such as Brittany D. Spitznagel, Kyle A. Emmitte, Yu Du, Alshaima'a M. Qunies, and Nigam M. Mishra. These partnerships have been instrumental in advancing research across various interconnected topics.

Publications by Weaver and collaborators have appeared multiple times in journals such as:

  • Journal of Medicinal Chemistry
  • Molecular Pharmacology
  • Journal of Biological Chemistry
  • Molecules
  • eLife

Best Publications

  • Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity.

    Alice L. Rodriguez;Mark D. Grier;Carrie K. Jones;Elizabeth J. Herman

  • Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4.

    Colleen M. Niswender;Kari A. Johnson;C. David Weaver;Carrie K. Jones

  • A thallium-sensitive, fluorescence-based assay for detecting and characterizing potassium channel modulators in mammalian cells.

    C. David Weaver;David Harden;Steven I. Dworetzky;Barbara Robertson

  • Identification of ML204, a Novel Potent Antagonist That Selectively Modulates Native TRPC4/C5 Ion Channels

    Melissa Miller;Jie Shi;Yingmin Zhu;Maksym Kustov

  • Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2

    Eric Delpire;Emily Days;L. Michelle Lewis;Dehui Mi

  • Functional Impact of Allosteric Agonist Activity of Selective Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 in Regulating Central Nervous System Function

    Meredith J. Noetzel;Jerri M. Rook;Paige N. Vinson;Hyekyung P. Cho

  • Calcium-dependent phosphorylation of symbiosome membrane proteins from nitrogen-fixing soybean nodules : evidence for phosphorylation of nodulin-26.

    C. David Weaver;Burnette Crombie;Gary Stacey;Daniel M. Roberts

  • Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity.

    Joy E. Marlo;Colleen M. Niswender;Emily L. Days;Thomas M. Bridges

  • ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice.

    Kristian Kaufmann;Ian Romaine;Emily Days;Conrado Pascual

  • High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1.

    L. Michelle Lewis;Gautam Bhave;Brian A. Chauder;Sreedatta Banerjee

  • A Novel Assay of Gi/o-Linked G Protein-Coupled Receptor Coupling to Potassium Channels Provides New Insights into the Pharmacology of the Group III Metabotropic Glutamate Receptors

    Colleen M. Niswender;Kari A. Johnson;Qingwei Luo;Jennifer E. Ayala

  • Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins.

    Thomas M. Bridges;Joy E. Marlo;Colleen M. Niswender;Carrie K. Jones

  • The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson's Disease

    Zixiu Xiang;Analisa D. Thompson;John T. Brogan;Michael L. Schulte

  • Development of a Selective Small-Molecule Inhibitor of Kir1.1, the Renal Outer Medullary Potassium Channel

    Gautam Bhave;Brian A. Chauder;Wen Liu;Eric S. Dawson

  • Mechanisms underlying the activation of G-protein-gated inwardly rectifying K+ (GIRK) channels by the novel anxiolytic drug, ML297

    Nicole Wydeven;Ezequiel Marron Fernandez de Velasco;Yu Du;Michael A. Benneyworth

  • Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M1 receptor function in the central nervous system

    Evan P Lebois;Thomas M Bridges;L. Michelle Lewis;Eric S Dawson

  • Protein phosphorylation stimulates the rate of malate uptake across the peribacteroid membrane of soybean nodules

    Li-Jun Ouyang;James Whelan;C.David Weaver;Daniel M. Roberts

  • Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe.

    Eric Delpire;Aleksandra Baranczak;Alex G. Waterson;Kwangho Kim

  • Sign Inversion in Photopharmacology: Incorporation of Cyclic Azobenzenes in Photoswitchable Potassium Channel Blockers and Openers

    Julie B. Trads;Julie B. Trads;Katharina Hüll;Katharina Hüll;Bryan S. Matsuura;Bryan S. Matsuura;Laura Laprell

  • A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer

    Stefanie Blättermann;Lucas Peters;Philipp Aaron Ottersbach;Andreas Bock

  • Phosphorylation of Nodulin 26 on Serine 262 Affects Its Voltage-sensitive Channel Activity in Planar Lipid Bilayers*

    Jung Weon Lee;Yuxin Zhang;C. David Weaver;Nirah H. Shomer

Frequent Co-Authors

Colleen M. Niswender
Colleen M. Niswender Vanderbilt University
P. Jeffrey Conn
P. Jeffrey Conn Vanderbilt University
Craig W. Lindsley
Craig W. Lindsley Vanderbilt University
Carrie K. Jones
Carrie K. Jones Vanderbilt University
Jens Meiler
Jens Meiler Vanderbilt University
Shaun R. Stauffer
Shaun R. Stauffer Cleveland Clinic
Eric Delpire
Eric Delpire Vanderbilt University
Annette G. Beck-Sickinger
Annette G. Beck-Sickinger Leipzig University
Min Li
Min Li Chinese Academy of Sciences
Dirk Trauner
Dirk Trauner University of Pennsylvania

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