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Neuroscience

D-Index
41
Citations
5921
World Ranking
7912
National Ranking
3402

Overview

Michael Bubser is affiliated with Vanderbilt University in the United States and conducts research primarily in the fields of Biochemistry, Genetics and Molecular Biology, as well as Neuroscience. Their work focuses on molecular biology and cellular and molecular neuroscience within these broader disciplines, with additional interests in cognitive neuroscience, endocrine and autonomic systems, and pharmacology.

The main topics that define Bubser's research include receptor mechanisms and signaling, neuroscience and neuropharmacology research, and nicotinic acetylcholine receptors study. They have also contributed to understanding neurotransmitter receptor influence on behavior, memory and neural mechanisms, pharmacological receptor mechanisms and effects, and circadian rhythm and melatonin.

They have published notably in several venues with multiple papers in the following journals:

  • Journal of Medicinal Chemistry
  • ACS Chemical Neuroscience
  • Alzheimer's & Dementia
  • Neuropsychopharmacology
  • Neuropharmacology

Frequent collaborators of Michael Bubser include Craig W. Lindsley, Carrie K. Jones, P. Jeffrey Conn, Sichen Chang, and Olivier Boutaud.

Their recent scientific articles demonstrate a focus on muscarinic acetylcholine receptor pharmacology and neuropharmacological approaches to opioid use disorder and neural modulation. Selected recent papers are:

  • Development of VU6019650: A Potent, Highly Selective, and Systemically Active Orthosteric Antagonist of the M5 Muscarinic Acetylcholine Receptor for the Treatment of Opioid Use Disorder, 2022, Journal of Medicinal Chemistry
  • Modulation of arousal and sleep/wake architecture by M1 PAM VU0453595 across young and aged rodents and nonhuman primates, 2020, Neuropsychopharmacology
  • Selective M5 muscarinic acetylcholine receptor negative allosteric modulator VU6008667 blocks acquisition of opioid self-administration, 2023, Neuropharmacology
  • Development of VU6036864: A Triazolopyridine-Based High-Quality Antagonist Tool Compound of the M5 Muscarinic Acetylcholine Receptor, 2024, Journal of Medicinal Chemistry
  • Discovery of VU6016235: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM), 2024, ACS Chemical Neuroscience

Best Publications

  • 6-Hydroxydopamine lesion of the rat prefrontal cortex increases locomotor activity, impairs acquisition of delayed alternation tasks, but does not affect uninterrupted tasks in the radial maze.

    Michael Bubser;Werner J. Schmidt

  • Novel Selective Allosteric Activator of the M1 Muscarinic Acetylcholine Receptor Regulates Amyloid Processing and Produces Antipsychotic-Like Activity in Rats

    Carrie K. Jones;Ashley E. Brady;Albert A. Davis;Zixiu Xiang

  • Muscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophrenia.

    Carrie K Jones;Nellie Byun;Michael Bubser

  • Differential Activation of Orexin Neurons by Antipsychotic Drugs Associated with Weight Gain

    Jim Fadel;Michael Bubser;Ariel Y. Deutch

  • Prepulse inhibition of the acoustic startle response of rats is reduced by 6-hydroxydopamine lesions of the medial prefrontal cortex.

    Michael Bubser;Michael Koch

  • Anticataleptic effects of the N-methyl-D-aspartate antagonist MK-801 in rats.

    Werner J. Schmidt;Michael Bubser

  • 5-HT2 Receptor Regulation of Extracellular GABA Levels in the Prefrontal Cortex

    Walid M. Abi-Saab;Michael Bubser;Robert H. Roth;Ariel Y. Deutch

  • DOI-Induced Activation of the Cortex: Dependence on 5-HT2A Heteroceptors on Thalamocortical Glutamatergic Neurons

    Jennifer L. Scruggs;Sachin Patel;Michael Bubser;Ariel Y. Deutch

  • Differential behavioural and neurochemical effects of competitive and non-competitive NMDA receptor antagonists in rats.

    Michael Bubser;Ute Keseberg;Petra K. Notz;Werner J. Schmidt

  • Deficient sensorimotor gating after 6-hydroxydopamine lesion of the rat medial prefrontal cortex is reversed by haloperidol.

    Michael Koch;Michael Bubser

  • Stress induces Fos expression in neurons of the thalamic paraventricular nucleus that innervate limbic forebrain sites.

    Michael Bubser;Ariel Y. Deutch

  • Selective Activation of M4 Muscarinic Acetylcholine Receptors Reverses MK-801-Induced Behavioral Impairments and Enhances Associative Learning in Rodents

    Michael Bubser;Thomas M Bridges;Thomas M Bridges;Ditte Dencker;Robert W Gould

  • Muscarinic Receptor Pharmacology and Circuitry for the Modulation of Cognition

    Michael Bubser;Nellie Byun;Michael R. Wood;Carrie K. Jones

  • The Metabotropic Glutamate Receptor 4-Positive Allosteric Modulator VU0364770 Produces Efficacy Alone and in Combination with l-DOPA or an Adenosine 2A Antagonist in Preclinical Rodent Models of Parkinson's Disease

    Carrie K. Jones;Michael Bubser;Analisa D. Thompson;Jonathan W. Dickerson

  • Biased mGlu5-positive allosteric modulators provide in vivo efficacy without potentiating mGlu5 modulation of NMDAR currents

    Jerri M. Rook;Zixiu Xiang;Xiaohui Lv;Ayan Ghoshal

  • Antipsychotic drug-like effects of the selective M4 muscarinic acetylcholine receptor positive allosteric modulator VU0152100.

    Nellie E Byun;Michael Grannan;Michael Bubser;Robert L Barry

  • Novel Allosteric Agonists of M1 Muscarinic Acetylcholine Receptors Induce Brain Region-Specific Responses That Correspond with Behavioral Effects in Animal Models

    G. J. Digby;M. J. Noetzel;M. Bubser;T. J. Utley

  • Tissue-specific variation of Ube3a protein expression in rodents and in a mouse model of Angelman syndrome.

    Richard M. Gustin;Terry Jo Bichell;Michael Bubser;Jennifer Daily

  • Behavioural pharmacology of glutamate in the basal ganglia.

    Werner J. Schmidt;Michael Bubser;Wolfgang Hauber

  • Dopaminergic regulation of orexin neurons.

    Michael Bubser;Jim R. Fadel;Lela L. Jackson;James H. Meador-Woodruff

Frequent Co-Authors

Carrie K. Jones
Carrie K. Jones Vanderbilt University
Colleen M. Niswender
Colleen M. Niswender Vanderbilt University
Ariel Y. Deutch
Ariel Y. Deutch Vanderbilt University
Nicholas J. Brandon
Nicholas J. Brandon Neumora Therapeutics Inc
Werner J. Schmidt
Werner J. Schmidt University of Tübingen
Wolfgang Hauber
Wolfgang Hauber University of Stuttgart
Michael Koch
Michael Koch University of Bremen
Jim R. Fadel
Jim R. Fadel University of South Carolina
Jeremy Veenstra-VanderWeele
Jeremy Veenstra-VanderWeele Columbia University
Elaine Sanders-Bush
Elaine Sanders-Bush Vanderbilt University

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