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D-Index & Metrics

Biology and Biochemistry

D-Index
104
Citations
35102
World Ranking
1270
National Ranking
747

Overview

Jürgen Wess is affiliated with the National Institutes of Health in the United States and is active in research primarily within the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their subfields of specialization include Molecular Biology, Physiology, Surgery, Cellular and Molecular Neuroscience, and Endocrinology, Diabetes and Metabolism.

Their work prominently focuses on topics related to receptor mechanisms and signaling, pancreatic function and diabetes, adipose tissue and metabolism, diabetes treatment and management, neuroscience and neuropharmacology research, neuropeptides and animal physiology, and the regulation of appetite and obesity.

Recent notable papers published by Jürgen Wess or in collaboration include:

  • β−Arrestins: Structure, Function, Physiology, and Pharmacological Perspectives, 2023, Pharmacological Reviews
  • Functional Selectivity of a Biased Cannabinoid-1 Receptor (CB1R) Antagonist, 2021, ACS Pharmacology & Translational Science
  • Novel metabolic role for BDNF in pancreatic β-cell insulin secretion, 2020, Nature Communications
  • Lack of adipocyte purinergic P2Y 6 receptor greatly improves whole body glucose homeostasis, 2020, Proceedings of the National Academy of Sciences
  • Use of DREADD Technology to Identify Novel Targets for Antidiabetic Drugs, 2020, The Annual Review of Pharmacology and Toxicology

Jürgen Wess frequently publishes in several key scientific journals, with the greatest number of publications appearing in:

  • Diabetes (11 publications)
  • Nature Communications (8 publications)
  • IUPHAR/BPS Guide to Pharmacology CITE (4 publications)
  • Science Advances (3 publications)
  • JCI Insight (2 publications)

Collaboration is an important aspect of their research activity. Frequent coauthors include:

  • Sai P. Pydi (22 coauthored works)
  • Yinghong Cui (19 coauthored works)
  • Luiz F. Barella (18 coauthored works)
  • Oksana Gavrilova (16 coauthored works)
  • Jaroslawna Meister (11 coauthored works)

The scope of Jürgen Wess's research spans molecular and physiological mechanisms underlying diabetes and metabolism. Their studies often focus on receptor signaling pathways and the cellular function of pancreatic beta cells, which are relevant to advances in diabetes treatment and management. The integration of neuroscience perspectives and pharmacological approaches is also evident in their work.

Best Publications

  • Activation and allosteric modulation of a muscarinic acetylcholine receptor

    Andrew C. Kruse;Aaron M. Ring;Aashish Manglik;Jianxin Hu

  • Structure and dynamics of the M3 muscarinic acetylcholine receptor

    Andrew C. Kruse;Jianxin Hu;Albert C. Pan;Daniel H. Arlow

  • G-protein-coupled receptors: molecular mechanisms involved in receptor activation and selectivity of G-protein recognition.

    Jürgen Wess

  • Antagonist binding profiles of five cloned human muscarinic receptor subtypes.

    F Dörje;J Wess;G Lambrecht;R Tacke

  • Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development.

    Jürgen Wess;Richard M. Eglen;Dinesh Gautam

  • Molecular biology of muscarinic acetylcholine receptors.

    Jurgen Wess

  • Molecular basis of receptor/G-protein-coupling selectivity.

    Jürgen Wess

  • Muscarinic acetylcholine receptor knockout mice: novel phenotypes and clinical implications.

    Jürgen Wess

  • Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean

    Masahisa Yamada;Tsuyoshi Miyakawa;Tsuyoshi Miyakawa;Alokesh Duttaroy;Akihiro Yamanaka

  • Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice

    Jesus Gomeza;Harlan Shannon;Evi Kostenis;Christian Felder

  • Hyperactivity and Intact Hippocampus-Dependent Learning in Mice Lacking the M1 Muscarinic Acetylcholine Receptor

    Tsuyoshi Miyakawa;Masahisa Yamada;Alokesh Duttaroy;Jürgen Wess

  • Coexpression studies with mutant muscarinic/adrenergic receptors provide evidence for intermolecular "cross-talk" between G-protein-linked receptors

    Roberto Maggio;Zvi Vogel;Jurgen Wess

  • Muscarinic acetylcholine receptors: novel opportunities for drug development

    Andrew C. Kruse;Brian K. Kobilka;Dinesh Gautam;Patrick M. Sexton

  • Lack of beta-arrestin signaling in the absence of active G proteins

    Manuel Grundmann;Nicole Merten;Davide Malfacini;Asuka Inoue;Asuka Inoue

  • Characterization of central inhibitory muscarinic autoreceptors by the use of muscarinic acetylcholine receptor knock-out mice

    Weilie Zhang;Anthony S. Basile;Jesus Gomeza;Laura A. Volpicelli

  • Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M4 muscarinic acetylcholine receptor knockout mice

    Jesus Gomeza;Lu Zhang;Evi Kostenis;Christian Felder

  • A chemical-genetic approach to study G protein regulation of β cell function in vivo

    Jean Marc Guettier;Dinesh Gautam;Marco Scarselli;Marco Scarselli;Inigo Ruiz De Azua

  • Gigantism and Acromegaly Due to Xq26 Microduplications and GPR101 Mutation

    Giampaolo Trivellin;Adrian F. Daly;Fabio R. Faucz;Bo Yuan

  • Cholinergic dilation of cerebral blood vessels is abolished in M 5 muscarinic acetylcholine receptor knockout mice

    Masahisa Yamada;Kathryn G. Lamping;Alokesh Duttaroy;Weilie Zhang

  • A critical role for β cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo

    Dinesh Gautam;Sung-Jun Han;Fadi F. Hamdan;Jongrye Jeon

Frequent Co-Authors

Oksana Gavrilova
Oksana Gavrilova National Institutes of Health
Fadi F. Hamdan
Fadi F. Hamdan University of Montreal
Chu-Xia Deng
Chu-Xia Deng University of Macau
Kenneth A. Jacobson
Kenneth A. Jacobson National Institutes of Health
Torsten Schöneberg
Torsten Schöneberg Leipzig University
Craig W. Lindsley
Craig W. Lindsley Vanderbilt University
Jie Liu
Jie Liu National Institutes of Health
P. Jeffrey Conn
P. Jeffrey Conn Vanderbilt University
Gitta Wörtwein
Gitta Wörtwein University of Copenhagen
David P.D. Woldbye
David P.D. Woldbye University of Copenhagen

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