Shaun R. Stauffer

Overview

Best Publications

• Pyrazole Ligands: Structure−Affinity/Activity Relationships and Estrogen Receptor-α-Selective Agonists

  Shaun R. Stauffer;Christopher J. Coletta;Rosanna Tedesco;Gisele Nishiguchi

  933
  Citations

• High turnover number and rapid, room-temperature amination of chloroarenes using saturated carbene ligands.

  Shaun R. Stauffer;Sunwoo Lee;James P. Stambuli;Sheila I. Hauck

  460
  Citations

• Novel structural templates for estrogen-receptor ligands and prospects for combinatorial synthesis of estrogens

  Brian E Fink;Deborah S Mortensen;Shaun R Stauffer;Zachary D Aron

  311
  Citations

• Copper-facilitated Suzuki reactions: application to 2-heterocyclic boronates.

  James Z Deng;Daniel V Paone;Anthony T Ginnetti;Hideki Kurihara

  253
  Citations

• Discovery, synthesis, and structure-based optimization of a series of N -(tert -Butyl)-2-(N -arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease

  Jon Jacobs;Valerie Grum-Tokars;Ya Zhou;Mark Turlington

  247
  Citations

• Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity.

  Alice L. Rodriguez;Mark D. Grier;Carrie K. Jones;Elizabeth J. Herman

  241
  Citations

• Functional Impact of Allosteric Agonist Activity of Selective Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 in Regulating Central Nervous System Function

  Meredith J. Noetzel;Jerri M. Rook;Paige N. Vinson;Hyekyung P. Cho

  181
  Citations

• Palladium-catalyzed arylation of ethyl cyanoacetate. Fluorescence resonance energy transfer as a tool for reaction discovery.

  Shaun R. Stauffer;Neil A. Beare;James P. Stambuli;John F. Hartwig

  178
  Citations

• Advancing Biological Understanding and Therapeutics Discovery with Small Molecule Probes

  Stuart L. Schreiber;Stuart L. Schreiber;Joanne D. Kotz;Min Li;Min Li;Jeffrey Aubé

  172
  Citations

• Fluorescence Resonance Energy Transfer (FRET) as a High-Throughput Assay for Coupling Reactions. Arylation of Amines as a Case Study

  Shaun R. Stauffer;John F. Hartwig

  149
  Citations

• Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding.

  Mark Turlington;Aspen Chun;Aspen Chun;Sakshi Tomar;Aimee Eggler

  147
  Citations

• Estrogen pyrazoles: defining the pyrazole core structure and the orientation of substituents in the ligand binding pocket of the estrogen receptor.

  Shaun R Stauffer;Ying Huang;Christopher J Coletta;Rosanna Tedesco

  129
  Citations

• Estrogen receptor ligands

  John A. Katzenellenbogen;Benita S. Katzenellenbogen;Brian E. Fink;Shaun R. Stauffer

  123
  Citations

• First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates.

  Sethu Sankaranarayanan;Marie A. Holahan;Dennis Colussi;Ming-Chih Crouthamel

  123
  Citations

• Triarylpyrazoles with basic side chains: development of pyrazole-based estrogen receptor antagonists.

  Shaun R Stauffer;Ying R Huang;Zachary D Aron;Christopher J Coletta

  115
  Citations

• High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein–Protein Interaction

  Shihan He;Timothy J. Senter;Jonathan Pollock;Changho Han

  111
  Citations

• Unique Signaling Profiles of Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Determine Differences in In Vivo Activity

  Jerri M. Rook;Meredith J. Noetzel;Wendy A. Pouliot;Thomas M. Bridges

  109
  Citations

• Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model.

  A Ghoshal;J M Rook;J W Dickerson;G N Roop

  103
  Citations

• Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4--The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS).

  Sarah E. St. John;Sakshi Tomar;Shaun R. Stauffer;Andrew D. Mesecar

  97
  Citations

• Solid-Phase Synthesis of Tetrasubstituted Pyrazoles, Novel Ligands for the Estrogen Receptor

  Shaun R. Stauffer;John A. Katzenellenbogen

  95
  Citations

• Investigating Metabotropic Glutamate Receptor 5 Allosteric Modulator Cooperativity, Affinity, and Agonism: Enriching Structure-Function Studies and Structure-Activity Relationships

  Karen J. Gregory;Meredith J. Noetzel;Jerri M. Rook;Paige N. Vinson

  84
  Citations