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Chemistry

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56
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11179
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11616
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3135

Biology and Biochemistry

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57
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13863
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Overview

Kathryn E. Carlson is affiliated with the University of Illinois at Urbana-Champaign in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant work also in the field of medicine.

Their main subfields of study include molecular biology, genetics, radiology, nuclear medicine and imaging, oncology, and immunology. Their work encompasses various topics, particularly in estrogen and related hormone effects, receptor mechanisms and signaling, ubiquitin and proteasome pathways, computational drug discovery methods, cutaneous lymphoproliferative disorders research, genomics and chromatin dynamics, and medicinal plant pharmacodynamics research.

Some of the recent papers authored by Kathryn E. Carlson include:

  • Discovery of ERD-12310A as an Exceptionally Potent and Orally Efficacious PROTAC Degrader of Estrogen Receptor α (ERα), 2024, Journal of Medicinal Chemistry
  • Phthalates Impair Estrogenic Regulation of HIF2α and Extracellular Vesicle Secretion by Human Endometrial Stromal Cells, 2025, Endocrinology
  • Somatic estrogen receptor α mutations that induce dimerization promote receptor activity and breast cancer proliferation, 2023, Journal of Clinical Investigation
  • Defining the Energetic Basis for a Conformational Switch Mediating Ligand-Independent Activation of Mutant Estrogen Receptors in Breast Cancer, 2021, Molecular Cancer Research
  • A mutant form of ERα associated with estrogen insensitivity affects the coupling between ligand binding and coactivator recruitment, 2020, Science Signaling

Frequent co-authors collaborating with Carlson include:

  • John A. Katzenellenbogen
  • Benita S. Katzenellenbogen
  • Yvonne Ziegler
  • René Houtman
  • J.C. Nwachukwu

Kathryn E. Carlson has published multiple articles in prominent venues. The most frequent publication venues for their work are:

  • Cancer Research
  • Journal of Investigative Dermatology
  • Journal of Clinical Investigation
  • Science Signaling
  • Journal of Medicinal Chemistry

Best Publications

  • Pyrazole Ligands: Structure−Affinity/Activity Relationships and Estrogen Receptor-α-Selective Agonists

    Shaun R. Stauffer;Christopher J. Coletta;Rosanna Tedesco;Gisele Nishiguchi

  • Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues.

    Marvin J. Meyers;Jun Sun;Kathryn E. Carlson;Gwendolyn A. Marriner

  • The estradiol pharmacophore: Ligand structure-estrogen receptor binding affinity relationships and a model for the receptor binding site

    Gregory M. Anstead;Kathryn E. Carlson;John A. Katzenellenbogen

  • Studies on the uterine, cytoplasmic estrogen binding protein. Thermal stability and ligand dissociation rate. An assay of empty and filled sites by exchange.

    John A. Katzenellenbogen;Howard J. Johnson;Kathryn E. Carlson

  • Activating ESR1 Mutations Differentially Affect the Efficacy of ER Antagonists

    Weiyi Toy;Hazel Weir;Pedram Razavi;Mandy Lawson

  • Synthesis and biological evaluation of a novel series of furans: Ligands selective for estrogen receptor α

    Deborah S. Mortensen;Alice L. Rodriguez;Kathryn E. Carlson;Jun Sun

  • Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation

    Sean W Fanning;Christopher G Mayne;Venkatasubramanian Dharmarajan;Kathryn E Carlson

  • Altered Ligand Binding Properties and Enhanced Stability of a Constitutively Active Estrogen Receptor: Evidence That an Open Pocket Conformation Is Required for Ligand Interaction†

    Kathryn E. Carlson;Inho Choi;Arvin Gee;Benita S. Katzenellenbogen

  • Pyrazolo[1,5-a]pyrimidines: Estrogen Receptor Ligands Possessing Estrogen Receptor β Antagonist Activity

    Dennis R. Compton;Shubin Sheng;Kathryn E. Carlson;Natalie A. Rebacz

  • Efficient and highly selective covalent labeling of the estrogen receptor with [3H]tamoxifen aziridine

    J A Katzenellenbogen;K E Carlson;D F Heiman;D W Robertson

  • Estrogen Receptor Dimerization: Ligand Binding Regulates Dimer Affinity and Dimer Dissociation Rate

    Anobel Tamrazi;Kathryn E. Carlson;Jonathan R. Daniels;Kyle M. Hurth

  • Coactivator peptides have a differential stabilizing effect on the binding of estrogens and antiestrogens with the estrogen receptor.

    Arvin C. Gee;Kathryn E. Carlson;Paolo G. V. Martini;Benita S. Katzenellenbogen

  • 11 beta-methoxy-, 11 beta-ethyl- and 17 alpha-ethynyl-substituted 16 alpha-fluoroestradiols: receptor-based imaging agents with enhanced uptake efficiency and selectivity.

    Martin G. Pomper;Henry VanBrocklin;Andrea M. Thieme;Ralph D. Thomas

  • Estrogen receptor subtype-selective ligands: asymmetric synthesis and biological evaluation of cis- and trans-5,11-dialkyl- 5,6,11, 12-tetrahydrochrysenes.

    Marvin J. Meyers;Jun Sun;Kathryn E. Carlson;Benita S. Katzenellenbogen

  • Lipophilic impurities, not phenolsulfonphthalein, account for the estrogenic activity in commercial preparations of phenol red

    Rajeshwar D. Bindal;Kathryn E. Carlson;Benita S. Katzenellenbogen;John A. Katzenellenbogen

  • Facile geometric isomerization of phenolic non-steroidal estrogens and antiestrogens: Limitations to the interpretation of experiments characterizing the activity of individual isomers

    John A. Katzenellenbogen;Kathryn E. Carlson;Benita S. Katzenellenbogen

  • Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells.

    Joshua D. Stender;Jerome C. Nwachukwu;Irida Kastrati;Yohan Kim

  • Mechanisms enforcing the estrogen receptor β selectivity of botanical estrogens

    Yan Jiang;Ping Gong;Zeynep Madak-Erdogan;Teresa Anne Martin

  • Exploration of dimensions of estrogen potency: parsing ligand binding and coactivator binding affinities

    M. Jeyakumar;Kathryn E. Carlson;Jillian R. Gunther;John A. Katzenellenbogen

  • Photoreactivity of some light-sensitive estrogen derivatives. Use of an exchange assay to determine their photointeraction with the rat uterine estrogen binding protein.

    John A. Katzenellenbogen;Howard J. Johnson;Kathryn E. Carlson;Harvey N. Myers

  • Synthesis of high affinity fluorine-substituted ligands for the androgen receptor. Potential agents for imaging prostatic cancer by positron emission tomography.

    Aijun Liu;Kathryn E. Carlson;John A. Katzenellenbogen

Frequent Co-Authors

John A. Katzenellenbogen
John A. Katzenellenbogen University of Illinois at Urbana-Champaign
Benita S. Katzenellenbogen
Benita S. Katzenellenbogen University of Illinois at Urbana-Champaign
Michael J. Welch
Michael J. Welch Washington University in St. Louis
Geoffrey L. Greene
Geoffrey L. Greene University of Chicago
Tiziano Tuccinardi
Tiziano Tuccinardi University of Pisa
Sarat Chandarlapaty
Sarat Chandarlapaty Memorial Sloan Kettering Cancer Center
Patrick R. Griffin
Patrick R. Griffin Scripps Research Institute
Emad Tajkhorshid
Emad Tajkhorshid University of Illinois at Urbana-Champaign
Michael R. Kilbourn
Michael R. Kilbourn University of Michigan–Ann Arbor
Myles Brown
Myles Brown Harvard University

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