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D-Index & Metrics

Biology and Biochemistry

D-Index
73
Citations
26556
World Ranking
5823
National Ranking
2758

Overview

Sarat Chandarlapaty is affiliated with the Memorial Sloan Kettering Cancer Center in the United States. Their research primarily spans across the fields of Medicine and Biochemistry, Genetics, and Molecular Biology, with significant contributions within oncology and related subfields.

The scientist's work is disseminated through frequent publications in well-recognized venues, including:

  • Cancer Research
  • Journal of Clinical Oncology
  • Clinical Cancer Research
  • Annals of Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)

The main subfields that define their research focus include:

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research
  • Molecular Biology
  • Genetics

The core topics of their investigations emphasize:

  • Advanced Breast Cancer Therapies
  • HER2/EGFR in Cancer Research
  • Cancer Genomics and Diagnostics
  • Cancer Treatment and Pharmacology
  • Breast Cancer Treatment Studies
  • PI3K/AKT/mTOR signaling in cancer
  • Estrogen and related hormone effects

Selected recent publications include:

  • "Unlocking the potential of antibody-drug conjugates for cancer therapy" (2021) published in Nature Reviews Clinical Oncology
  • "Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients" (2022) published in Cell
  • "Enhanced specificity of clinical high-sensitivity tumor mutation profiling in cell-free DNA via paired normal sequencing using MSK-ACCESS" (2021) published in Nature Communications
  • "Alterations in PTEN and ESR1 promote clinical resistance to alpelisib plus aromatase inhibitors" (2020) published in Nature Cancer
  • "Independent real-world application of a clinical-grade automated prostate cancer detection system" (2021) published in The Journal of Pathology

Frequent coauthors collaborating with Sarat Chandarlapaty include:

  • Pedram Razavi
  • Jorge S. Reis-Filho
  • Fresia Pareja
  • Anton Safonov
  • Britta Weigelt

Best Publications

  • OncoKB: A Precision Oncology Knowledge Base.

    Debyani Chakravarty;Jianjiong Gao;Sarah Phillips;Ritika Kundra

  • Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer

    Brett S. Carver;Caren Chapinski;John Wongvipat;Haley Hieronymus

  • ESR1 ligand-binding domain mutations in hormone-resistant breast cancer

    Weiyi Toy;Yang Shen;Helen Won;Bradley Green

  • AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity

    Sarat Chandarlapaty;Ayana Sawai;Maurizio Scaltriti;Vanessa Rodrik-Outmezguine

  • The Genomic Landscape of Endocrine-Resistant Advanced Breast Cancers.

    Pedram Razavi;Matthew T. Chang;Guotai Xu;Chaitanya Bandlamudi

  • Unlocking the potential of antibody-drug conjugates for cancer therapy.

    Joshua Z. Drago;Shanu Modi;Shanu Modi;Sarat Chandarlapaty;Sarat Chandarlapaty

  • Relief of Profound Feedback Inhibition of Mitogenic Signaling by RAF Inhibitors Attenuates Their Activity in BRAFV600E Melanomas

    Piro Lito;Christine A. Pratilas;Eric W. Joseph;Madhavi Tadi

  • PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer

    V. Serra;M. Scaltriti;L. Prudkin;Pieter Eichhorn

  • HER2-amplified breast cancer: mechanisms of trastuzumab resistance and novel targeted therapies

    Devika Gajria;Sarat Chandarlapaty

  • Analysis of ESR1 mutation in circulating tumor DNA demonstrates evolution during therapy for metastatic breast cancer

    Gaia Schiavon;Gaia Schiavon;Sarah Hrebien;Isaac Garcia-Murillas;Rosalind J. Cutts

  • HSP90 Inhibition Is Effective in Breast Cancer: A Phase II Trial of Tanespimycin (17-AAG) Plus Trastuzumab in Patients with HER2-Positive Metastatic Breast Cancer Progressing on Trastuzumab

    Shanu Modi;Alison T. Stopeck;Hannah M. Linden;David B. Solit

  • mTOR Kinase Inhibition Causes Feedback-Dependent Biphasic Regulation of AKT Signaling

    Vanessa S. Rodrik-Outmezguine;Sarat Chandarlapaty;Nen C. Pagano;Poulikos I. Poulikakos

  • Prevalence of ESR1 Mutations in Cell-Free DNA and Outcomes in Metastatic Breast Cancer: A Secondary Analysis of the BOLERO-2 Clinical Trial.

    Sarat Chandarlapaty;David Chen;Wei He;Patricia Sung

  • Systemic Therapy for Patients With Advanced Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline

    Sharon H. Giordano;Sarah Temin;Jeffrey J. Kirshner;Sarat Chandarlapaty

  • Loss of the FAT1 Tumor Suppressor Promotes Resistance to CDK4/6 Inhibitors via the Hippo Pathway

    Zhiqiang Li;Pedram Razavi;Pedram Razavi;Qing Li;Weiyi Toy

  • PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor–positive breast cancer

    Ana Bosch;Zhiqiang Li;Anna Bergamaschi;Haley Ellis

  • Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2+ breast cancer patients

    Maurizio Scaltriti;Pieter J. Eichhorn;Javier Cortés;Ludmila Prudkin

  • Acquired CDK6 amplification promotes breast cancer resistance to CDK4/6 inhibitors and loss of ER signaling and dependence

    C Yang;Z Li;T Bhatt;M Dickler

  • Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling.

    Qing-Bai She;Sarat Chandarlapaty;Qing Ye;Jose Lobo

  • Accelerating Discovery of Functional Mutant Alleles in Cancer

    Matthew T. Chang;Matthew T. Chang;Tripti Shrestha Bhattarai;Alison M. Schram;Craig M. Bielski

Frequent Co-Authors

José Baselga
José Baselga Memorial Sloan Kettering Cancer Center
Neal Rosen
Neal Rosen Memorial Sloan Kettering Cancer Center
Jorge S. Reis-Filho
Jorge S. Reis-Filho Memorial Sloan Kettering Cancer Center
David B. Solit
David B. Solit Memorial Sloan Kettering Cancer Center
Michael F. Berger
Michael F. Berger Memorial Sloan Kettering Cancer Center
Clifford A. Hudis
Clifford A. Hudis Memorial Sloan Kettering Cancer Center
Larry Norton
Larry Norton Memorial Sloan Kettering Cancer Center
David M. Hyman
David M. Hyman Memorial Sloan Kettering Cancer Center
Mark E. Robson
Mark E. Robson Memorial Sloan Kettering Cancer Center
Geoffrey L. Greene
Geoffrey L. Greene University of Chicago

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