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Medicine

D-Index
139
Citations
65996
World Ranking
1769
National Ranking
1011

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Neal Rosen is affiliated with the Memorial Sloan Kettering Cancer Center in the United States. Their research primarily focuses on molecular biology, oncology, and cancer research, with a significant emphasis on biochemistry, genetics, and molecular biology as broader fields of study.

Their work covers specialized subfields such as molecular biology, oncology, pulmonary and respiratory medicine, and immunology. Within these areas, Neal Rosen concentrates on topics including melanoma and MAPK pathways, PI3K/AKT/mTOR signaling in cancer, protein degradation and inhibitors, colorectal cancer treatments and studies, cancer genomics and diagnostics, cancer mechanisms and therapy, as well as protein kinase regulation and GTPase signaling.

Neal Rosen has a substantial publication record across various scientific venues. The frequent publication venues include:

  • Cancer Research
  • The Prostate
  • Cancer Discovery
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Clinical Cancer Research

Their recent papers illustrate an active engagement with cancer biology and targeted therapies. Some notable publications are:

  • "Targeted drug delivery strategies for precision medicines," 2021, Nature Reviews Materials
  • "EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer," 2020, Cancer Discovery
  • "HER2-Mediated Internalization of Cytotoxic Agents in ERBB2 Amplified or Mutant Lung Cancers," 2020, Cancer Discovery
  • "INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors," 2021, Cancer Discovery
  • "Mutant-selective degradation by BRAF-targeting PROTACs," 2021, Nature Communications

Throughout their career, Neal Rosen has collaborated frequently with other researchers. Their most frequent co-authors include:

  • Elisa de Stanchina
  • Rona Yaeger
  • David B. Solit
  • Sandra Misale
  • Radha Mukherjee

Among recognitions, Neal Rosen has been named a member of the Association of American Physicians.

Best Publications

  • mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt

    Kathryn E. O'Reilly;Fredi Rojo;Qing Bai She;David Solit

  • RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

    Poulikos I. Poulikakos;Chao Zhang;Gideon Bollag;Kevan M. Shokat

  • Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent

    C E Stebbins;A A Russo;C Schneider;N Rosen

  • RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

    Poulikos I. Poulikakos;Yogindra Persaud;Manickam Janakiraman;Xiangju Kong

  • BRAF mutation predicts sensitivity to MEK inhibition

    David B. Solit;Levi A. Garraway;Levi A. Garraway;Christine A. Pratilas;Ayana Sawai

  • Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer

    Brett S. Carver;Caren Chapinski;John Wongvipat;Haley Hieronymus

  • AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity

    Sarat Chandarlapaty;Ayana Sawai;Maurizio Scaltriti;Vanessa Rodrik-Outmezguine

  • Targeted drug delivery strategies for precision medicines

    Mandana T. Manzari;Yosi Shamay;Hiroto Kiguchi;Hiroto Kiguchi;Neal Rosen;Neal Rosen

  • Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function.

    Andrea D. Basso;Andrea D. Basso;David B. Solit;Gabriela Chiosis;Banabihari Giri

  • Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer

    Rona Yaeger;Walid K. Chatila;Marla D. Lipsyc;Jaclyn F. Hechtman

  • The Tyrosine Kinase Inhibitor ZD1839 ("Iressa") Inhibits HER2-driven Signaling and Suppresses the Growth of HER2-overexpressing Tumor Cells

    Mark M. Moasser;Andrea Basso;Steven D. Averbuch;Neal Rosen

  • Tumor adaptation and resistance to RAF inhibitors.

    Piro Lito;Neal Rosen;David B Solit

  • V600EBRAF is associated with disabled feedback inhibition of RAF–MEK signaling and elevated transcriptional output of the pathway

    Christine A. Pratilas;Barry S. Taylor;Barry S. Taylor;Qing Ye;Agnes Viale

  • Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity

    Lao H. Saal;Peter Johansson;Karolina Holm;Sofia K. Gruvberger-Saal

  • Drugging the cancer chaperone HSP90: combinatorial therapeutic exploitation of oncogene addiction and tumor stress.

    Paul Workman;Francis Burrows;Len Neckers;Neal Rosen

  • Relief of Profound Feedback Inhibition of Mitogenic Signaling by RAF Inhibitors Attenuates Their Activity in BRAFV600E Melanomas

    Piro Lito;Christine A. Pratilas;Eric W. Joseph;Madhavi Tadi

  • PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer

    V. Serra;M. Scaltriti;L. Prudkin;Pieter Eichhorn

  • Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors.

    Roberto Bianco;Incheol Shin;Christoph A. Ritter;F. Michael Yakes

  • 17-Allylamino-17-demethoxygeldanamycin Induces the Degradation of Androgen Receptor and HER-2/neu and Inhibits the Growth of Prostate Cancer Xenografts

    David B. Solit;Fuzhong F. Zheng;Maria Drobnjak;Pamela N. Münster

  • A Peptidomimetic Inhibitor of Farnesyl:Protein Transferase Blocks the Anchorage-dependent and -independent Growth of Human Tumor Cell Lines

    Laura Sepp-Lorenzino;Zhenping Ma;Elaine Rands;Nancy E. Kohl

Frequent Co-Authors

David B. Solit
David B. Solit Memorial Sloan Kettering Cancer Center
Sarat Chandarlapaty
Sarat Chandarlapaty Memorial Sloan Kettering Cancer Center
José Baselga
José Baselga Memorial Sloan Kettering Cancer Center
Barry S. Taylor
Barry S. Taylor Memorial Sloan Kettering Cancer Center
Michael F. Berger
Michael F. Berger Memorial Sloan Kettering Cancer Center
Gabriela Chiosis
Gabriela Chiosis Memorial Sloan Kettering Cancer Center
Omar Abdel-Wahab
Omar Abdel-Wahab Memorial Sloan Kettering Cancer Center
Howard I. Scher
Howard I. Scher Memorial Sloan Kettering Cancer Center
Paul B. Chapman
Paul B. Chapman Memorial Sloan Kettering Cancer Center
Samuel J. Danishefsky
Samuel J. Danishefsky Columbia University

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