Leonard M. Neckers

What is he best known for?

The fields of study he is best known for:

• Gene
• Enzyme
• Cancer

His scientific interests lie mostly in Hsp90, Geldanamycin, Cancer research, Heat shock protein and Cell biology. Len Neckers is involved in the study of Hsp90 that focuses on Hsp90 inhibitor in particular. His Geldanamycin research is multidisciplinary, incorporating elements of Endoplasmic reticulum, Receptor tyrosine kinase, Ansamycin and Cell-free system.

His Cancer research study combines topics in areas such as Cancer cell, Tyrosine kinase, Kinase and Mast cell. His studies examine the connections between Heat shock protein and genetics, as well as such issues in Cell, with regards to Extracellular, Matrix metalloproteinase, MMP2, 3T3 cells and Cytosol. His research in Cell biology intersects with topics in Carcinogenesis, Regulation of gene expression, Reporter gene and MRNA stabilization.

His most cited work include:

• Targeting the dynamic HSP90 complex in cancer (1052 citations)
• HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability (707 citations)
• Hsp90 molecular chaperone inhibitors: are we there yet? (690 citations)

What are the main themes of his work throughout his whole career to date?

Len Neckers mostly deals with Hsp90, Cancer research, Cell biology, Heat shock protein and Chaperone. His Hsp90 study combines topics from a wide range of disciplines, such as Cancer cell and Signal transduction. Len Neckers interconnects Cancer, Protein kinase B, Tyrosine kinase, Hsp90 inhibitor and Kinase in the investigation of issues within Cancer research.

His biological study deals with issues like HSF1, which deal with fields such as Transcription factor. His studies in Heat shock protein integrate themes in fields like Internal medicine, Prostate cancer and Intracellular. His research integrates issues of Protein structure, CDC37, Metastasis and Acetylation in his study of Chaperone.

He most often published in these fields:

• Hsp90 (42.29%)
• Cancer research (38.33%)
• Cell biology (28.19%)

What were the highlights of his more recent work (between 2013-2020)?

• Hsp90 (42.29%)
• Heat shock protein (27.75%)
• Cancer research (38.33%)

In recent papers he was focusing on the following fields of study:

Len Neckers mainly investigates Hsp90, Heat shock protein, Cancer research, Cell biology and Chaperone. Hsp90 is a subfield of Biochemistry that he explores. The concepts of his Heat shock protein study are interwoven with issues in Proteome, ATPase and Yeast.

Len Neckers has included themes like Cell growth, Gene knockdown, Hsp90 inhibitor, Kinase and Androgen receptor in his Cancer research study. His work deals with themes such as SUMO protein, HSF1 and Folding, which intersect with Cell biology. The study incorporates disciplines such as Protein structure, CDC37, Atpase activity and Phosphorylation in addition to Chaperone.

Between 2013 and 2020, his most popular works were:

• Asymmetric Hsp90 N Domain SUMOylation Recruits Aha1 and ATP-Competitive Inhibitors (76 citations)
• Regulation and function of the human HSP90AA1 gene. (75 citations)
• Targeting ABL1-Mediated Oxidative Stress Adaptation in Fumarate Hydratase-Deficient Cancer (63 citations)

In his most recent research, the most cited papers focused on:

• Gene
• Enzyme
• Cancer

His primary scientific interests are in Hsp90, Heat shock protein, Chaperone, Biochemistry and Cell biology. His Hsp90 study incorporates themes from Cancer, Disease and Small molecule. Len Neckers works in the field of Heat shock protein, focusing on Hsp90 inhibitor in particular.

His Chaperone research incorporates themes from Protein structure, Cancer cell, Kinase and Phosphorylation. In his work, Protein kinase B is strongly intertwined with Cancer research, which is a subfield of Biochemistry. His Cell biology study deals with ATPase intersecting with Saccharomyces cerevisiae, Adenosine triphosphate and SUMO protein.