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Molecular Biology

D-Index
99
Citations
38897
World Ranking
550
National Ranking
44

Research.com Recognitions

  • 2012 - Member of Academia Europaea
  • 2008 - Fellow of the Royal Society, United Kingdom

Overview

Laurence H. Pearl is affiliated with the University of Sussex in the United Kingdom. Their research primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with a particular focus on Molecular Biology as a subfield. Additional areas of study include Oncology, Materials Chemistry, Genetics, and Epidemiology.

The scientist's research topics cover a range of subjects related to molecular and cellular biology. These topics include DNA Repair Mechanisms, Enzyme Structure and Function, Heat shock proteins research, PARP inhibition in cancer therapy, Genomics and Chromatin Dynamics, Epigenetics and DNA Methylation, and Protein Structure and Dynamics.

Research outputs include publications in multiple academic venues. Notable frequent publication venues are bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, SSRN Electronic Journal, Science Advances, and DNA repair.

Among the recent papers are:

  • HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation, 2022, Nature Communications
  • The structure-function relationship of oncogenic LMTK3, 2020, Science Advances
  • Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1, 2021, DNA repair
  • Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone, 2021, Cell Reports
  • CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle, 2021, mBio

Collaboration is a significant element of their scientific work. Frequent co-authors include Antony W. Oliver, M.W. Day, Jyoti S. Choudhary, Mohinder Pal, and Hugo Muñoz-Hernández.

Laurence H. Pearl has been recognized by professional bodies, including being named a Member of Academia Europaea in 2012 and a Fellow of the Royal Society in the United Kingdom in 2008.

Best Publications

  • Identification and Structural Characterization of the ATP/ADP-Binding Site in the Hsp90 Molecular Chaperone

    Chrisostomos Prodromou;S. Mark Roe;Ronan O'Brien;John Edward Simon Durham Ladbury

  • Structure and Mechanism of the Hsp90 Molecular Chaperone Machinery

    Laurence H. Pearl;Chrisostomos Prodromou

  • Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin

    S M Roe;C Prodromou;R O'Brien;J E Ladbury

  • Crystal structure of an Hsp90–nucleotide–p23/Sba1 closed chaperone complex

    Maruf M. U. Ali;S. Mark Roe;Cara K. Vaughan;Phillipe Meyer;Phillipe Meyer

  • GSK-3-Selective Inhibitors Derived from Tyrian Purple Indirubins

    Laurent Meijer;Alexios-Leandros Skaltsounis;Prokopios Magiatis;Panagiotis Polychronopoulos

  • ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo

    Barry Panaretou;Chrisostomos Prodromou;S. Mark Roe;Ronan O'Brien

  • A structural model for the retroviral proteases.

    Laurence H. Pearl;William R. Taylor;William R. Taylor

  • Crystal Structure of Glycogen Synthase Kinase 3β: Structural Basis for Phosphate-Primed Substrate Specificity and Autoinhibition

    Rana Dajani;Elizabeth Fraser;S. Mark Roe;Neville Young

  • DNA repair, genome stability and cancer: a historical perspective

    Penny A. Jeggo;Laurence H. Pearl;Antony M. Carr

  • The ATPase cycle of Hsp90 drives a molecular ‘clamp’ via transient dimerization of the N-terminal domains

    Chrisostomos Prodromou;Barry Panaretou;Barry Panaretou;Shahzad Chohan;Giuliano Siligardi

  • Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1.

    Barry Panaretou;Giuliano Siligardi;Philippe Meyer;Alison Maloney

  • Structural and Functional Analysis of the Middle Segment of Hsp90 Implications for ATP Hydrolysis and Client Protein and Cochaperone Interactions

    Philippe Meyer;Chrisostomos Prodromou;Bin Hu;Cara Vaughan

  • Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones

    Chrisostomos Prodromou;Giuliano Siligardi;Ronan O'Brien;Derek N. Woolfson

  • NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis

    Suzanne A Eccles;Andy Massey;Florence I Raynaud;Swee Y Sharp

  • The Hsp90 molecular chaperone: an open and shut case for treatment

    Laurence H. Pearl;Chrisostomos Prodromou;Paul Workman

  • 4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer

    Paul A. Brough;Wynne Aherne;Xavier Barril;Jenifer Borgognoni

  • Therapeutic opportunities within the DNA damage response

    Laurence H. Pearl;Amanda C. Schierz;Simon E. Ward;Bissan Al-Lazikani

  • The structural basis of specific base-excision repair by uracil–DNA glycosylase

    Renos Savva;Katherine McAuley-Hecht;Tom Brown;Laurence Pearl

  • Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases.

    Panagiotis Polychronopoulos;Prokopios Magiatis;Alexios-Leandros Skaltsounis;Vassilios Myrianthopoulos

  • Chaperoned Ubiquitylation-Crystal Structures of the Chip U Box E3 Ubiquitin Ligase and a Chip-Ubc13-Uev1A Complex

    Minghao Zhang;Mark Windheim;S. Mark Roe;Mark Peggie

Frequent Co-Authors

Chrisostomos Prodromou
Chrisostomos Prodromou University of Sussex
S. Mark Roe
S. Mark Roe University of Sussex
Peter W. Piper
Peter W. Piper University of Sheffield
Paul Workman
Paul Workman Institute of Cancer Research
Oscar Llorca
Oscar Llorca Spanish National Research Council
Tom L. Blundell
Tom L. Blundell University of Cambridge
Tom Brown
Tom Brown University of Oxford
Ian Collins
Ian Collins PharmEnable Therapeutics
David A. Isenberg
David A. Isenberg University College London
David S. Latchman
David S. Latchman University College London

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