World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
99
Citations
38897
World Ranking
550
National Ranking
44

Laurence H. Pearl publication distribution in Molecular Biology in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Molecular Biology in 2026. The highlighted bar marks where Laurence H. Pearl sits on this spectrum.

47–56 publications: 7 scientists 57–66 publications: 17 scientists 67–76 publications: 65 scientists 77–86 publications: 90 scientists 87–96 publications: 125 scientists 97–106 publications: 131 scientists 107–116 publications: 162 scientists 117–126 publications: 177 scientists 127–136 publications: 158 scientists 137–146 publications: 158 scientists 147–156 publications: 146 scientists 157–166 publications: 159 scientists 167–176 publications: 131 scientists 177–186 publications: 110 scientists 187–196 publications: 112 scientists 197–206 publications: 100 scientists 207–216 publications: 89 scientists 217–226 publications: 98 scientists 227–236 publications: 74 scientists 237–246 publications: 72 scientists 247–256 publications: 63 scientists 257–266 publications: 53 scientists 267–276 publications: 54 scientists 277–286 publications: 49 scientists 287–296 publications: 52 scientists 297–306 publications: 43 scientists 307–316 publications: 46 scientists 317–326 publications: 41 scientists 327–336 publications: 42 scientists 337–346 publications: 31 scientists 347–356 publications: 28 scientists 357–366 publications: 29 scientists 367–376 publications: 26 scientists 377–386 publications: 24 scientists 387–396 publications: 24 scientists 397–406 publications: 14 scientists 407–416 publications: 13 scientists 417–426 publications: 20 scientists 427–436 publications: 12 scientists 437–446 publications: 20 scientists 447–456 publications: 11 scientists 457–466 publications: 10 scientists 467–476 publications: 14 scientists 477–486 publications: 14 scientists 487–496 publications: 10 scientists 497–506 publications: 13 scientists 507–516 publications: 13 scientists 517–526 publications: 2 scientists 527–536 publications: 4 scientists 537–546 publications: 6 scientists 547–556 publications: 8 scientists 557–563 publications: 6 scientists 564+ publications: 100 scientists
47 publications 564+

This scientist: 302 publications — 81st percentile

81% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 564 publications or more.

Laurence H. Pearl D-index placement in Molecular Biology in 2026

The chart shows the D-index (discipline H-index) distribution of Molecular Biology scientists ranked by Research.com in 2026. The highlighted bar marks where Laurence H. Pearl sits on this spectrum.

40–41 D-Index: 36 scientists 42–43 D-Index: 101 scientists 44–45 D-Index: 115 scientists 46–47 D-Index: 121 scientists 48–49 D-Index: 118 scientists 50–51 D-Index: 130 scientists 52–53 D-Index: 106 scientists 54–55 D-Index: 116 scientists 56–57 D-Index: 113 scientists 58–59 D-Index: 129 scientists 60–61 D-Index: 120 scientists 62–63 D-Index: 105 scientists 64–65 D-Index: 131 scientists 66–67 D-Index: 95 scientists 68–69 D-Index: 97 scientists 70–71 D-Index: 106 scientists 72–73 D-Index: 83 scientists 74–75 D-Index: 89 scientists 76–77 D-Index: 77 scientists 78–79 D-Index: 70 scientists 80–81 D-Index: 73 scientists 82–83 D-Index: 60 scientists 84–85 D-Index: 48 scientists 86–87 D-Index: 45 scientists 88–89 D-Index: 50 scientists 90–91 D-Index: 31 scientists 92–93 D-Index: 51 scientists 94–95 D-Index: 43 scientists 96–97 D-Index: 38 scientists 98–99 D-Index: 39 scientists 100–101 D-Index: 41 scientists 102–103 D-Index: 29 scientists 104–105 D-Index: 33 scientists 106–107 D-Index: 35 scientists 108–109 D-Index: 20 scientists 110–111 D-Index: 38 scientists 112–113 D-Index: 19 scientists 114–115 D-Index: 28 scientists 116–117 D-Index: 13 scientists 118–119 D-Index: 23 scientists 120–121 D-Index: 16 scientists 122–123 D-Index: 15 scientists 124–125 D-Index: 11 scientists 126–127 D-Index: 21 scientists 128–129 D-Index: 7 scientists 130–131 D-Index: 13 scientists 132–133 D-Index: 14 scientists 134–135 D-Index: 17 scientists 136–137 D-Index: 9 scientists 138–139 D-Index: 8 scientists 140–141 D-Index: 16 scientists 142–143 D-Index: 7 scientists 144 D-Index: 7 scientists 145+ D-Index: 100 scientists
40 D-Index 145+

This scientist: 99 D-Index — 82nd percentile

82% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 145 D-Index or more.

Research.com Recognitions

  • 2012 - Member of Academia Europaea
  • 2008 - Fellow of the Royal Society, United Kingdom

Overview

Laurence H. Pearl is affiliated with the University of Sussex in the United Kingdom. Their research primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with a particular focus on Molecular Biology as a subfield. Additional areas of study include Oncology, Materials Chemistry, Genetics, and Epidemiology.

The scientist's research topics cover a range of subjects related to molecular and cellular biology. These topics include DNA Repair Mechanisms, Enzyme Structure and Function, Heat shock proteins research, PARP inhibition in cancer therapy, Genomics and Chromatin Dynamics, Epigenetics and DNA Methylation, and Protein Structure and Dynamics.

Research outputs include publications in multiple academic venues. Notable frequent publication venues are bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, SSRN Electronic Journal, Science Advances, and DNA repair.

Among the recent papers are:

  • HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation, 2022, Nature Communications
  • The structure-function relationship of oncogenic LMTK3, 2020, Science Advances
  • Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1, 2021, DNA repair
  • Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone, 2021, Cell Reports
  • CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle, 2021, mBio

Collaboration is a significant element of their scientific work. Frequent co-authors include Antony W. Oliver, M.W. Day, Jyoti S. Choudhary, Mohinder Pal, and Hugo Muñoz-Hernández.

Laurence H. Pearl has been recognized by professional bodies, including being named a Member of Academia Europaea in 2012 and a Fellow of the Royal Society in the United Kingdom in 2008.

Best Publications

  • Identification and Structural Characterization of the ATP/ADP-Binding Site in the Hsp90 Molecular Chaperone

    Chrisostomos Prodromou;S. Mark Roe;Ronan O'Brien;John Edward Simon Durham Ladbury

  • Structure and Mechanism of the Hsp90 Molecular Chaperone Machinery

    Laurence H. Pearl;Chrisostomos Prodromou

  • Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin

    S M Roe;C Prodromou;R O'Brien;J E Ladbury

  • Crystal structure of an Hsp90–nucleotide–p23/Sba1 closed chaperone complex

    Maruf M. U. Ali;S. Mark Roe;Cara K. Vaughan;Phillipe Meyer;Phillipe Meyer

  • GSK-3-Selective Inhibitors Derived from Tyrian Purple Indirubins

    Laurent Meijer;Alexios-Leandros Skaltsounis;Prokopios Magiatis;Panagiotis Polychronopoulos

  • ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo

    Barry Panaretou;Chrisostomos Prodromou;S. Mark Roe;Ronan O'Brien

  • A structural model for the retroviral proteases.

    Laurence H. Pearl;William R. Taylor;William R. Taylor

  • Crystal Structure of Glycogen Synthase Kinase 3β: Structural Basis for Phosphate-Primed Substrate Specificity and Autoinhibition

    Rana Dajani;Elizabeth Fraser;S. Mark Roe;Neville Young

  • DNA repair, genome stability and cancer: a historical perspective

    Penny A. Jeggo;Laurence H. Pearl;Antony M. Carr

  • The ATPase cycle of Hsp90 drives a molecular ‘clamp’ via transient dimerization of the N-terminal domains

    Chrisostomos Prodromou;Barry Panaretou;Barry Panaretou;Shahzad Chohan;Giuliano Siligardi

  • Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1.

    Barry Panaretou;Giuliano Siligardi;Philippe Meyer;Alison Maloney

  • Structural and Functional Analysis of the Middle Segment of Hsp90 Implications for ATP Hydrolysis and Client Protein and Cochaperone Interactions

    Philippe Meyer;Chrisostomos Prodromou;Bin Hu;Cara Vaughan

  • Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones

    Chrisostomos Prodromou;Giuliano Siligardi;Ronan O'Brien;Derek N. Woolfson

  • NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis

    Suzanne A Eccles;Andy Massey;Florence I Raynaud;Swee Y Sharp

  • The Hsp90 molecular chaperone: an open and shut case for treatment

    Laurence H. Pearl;Chrisostomos Prodromou;Paul Workman

  • 4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer

    Paul A. Brough;Wynne Aherne;Xavier Barril;Jenifer Borgognoni

  • Therapeutic opportunities within the DNA damage response

    Laurence H. Pearl;Amanda C. Schierz;Simon E. Ward;Bissan Al-Lazikani

  • The structural basis of specific base-excision repair by uracil–DNA glycosylase

    Renos Savva;Katherine McAuley-Hecht;Tom Brown;Laurence Pearl

  • Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases.

    Panagiotis Polychronopoulos;Prokopios Magiatis;Alexios-Leandros Skaltsounis;Vassilios Myrianthopoulos

  • Chaperoned Ubiquitylation-Crystal Structures of the Chip U Box E3 Ubiquitin Ligase and a Chip-Ubc13-Uev1A Complex

    Minghao Zhang;Mark Windheim;S. Mark Roe;Mark Peggie

Frequent Co-Authors

Chrisostomos Prodromou
Chrisostomos Prodromou University of Sussex
S. Mark Roe
S. Mark Roe University of Sussex
Peter W. Piper
Peter W. Piper University of Sheffield
Paul Workman
Paul Workman Institute of Cancer Research
Oscar Llorca
Oscar Llorca Spanish National Research Council
Tom L. Blundell
Tom L. Blundell University of Cambridge
Tom Brown
Tom Brown University of Oxford
Ian Collins
Ian Collins PharmEnable Therapeutics
David A. Isenberg
David A. Isenberg University College London
David S. Latchman
David S. Latchman University College London

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