S. Mark Roe

Overview

Best Publications

• Mechanism of Activation of the Raf-Erk Signaling Pathway by Oncogenic Mutations of B-Raf

  Paul T.C Wan;Mathew J Garnett;S.Mark Roe;Sharlene Lee

  3238
  Citations

• Identification and Structural Characterization of the ATP/ADP-Binding Site in the Hsp90 Molecular Chaperone

  Chrisostomos Prodromou;S. Mark Roe;Ronan O'Brien;John Edward Simon Durham Ladbury

  1636
  Citations

• Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin

  S M Roe;C Prodromou;R O'Brien;J E Ladbury

  1227
  Citations

• Crystal structure of an Hsp90–nucleotide–p23/Sba1 closed chaperone complex

  Maruf M. U. Ali;S. Mark Roe;Cara K. Vaughan;Phillipe Meyer;Phillipe Meyer

  1141
  Citations

• GSK-3-Selective Inhibitors Derived from Tyrian Purple Indirubins

  Laurent Meijer;Alexios-Leandros Skaltsounis;Prokopios Magiatis;Panagiotis Polychronopoulos

  991
  Citations

• ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo

  Barry Panaretou;Chrisostomos Prodromou;S. Mark Roe;Ronan O'Brien

  936
  Citations

• Crystal Structure of Glycogen Synthase Kinase 3β: Structural Basis for Phosphate-Primed Substrate Specificity and Autoinhibition

  Rana Dajani;Elizabeth Fraser;S. Mark Roe;Neville Young

  861
  Citations

• Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex.

  James S. Parker;S. Mark Roe;David Barford

  673
  Citations

• The ATPase cycle of Hsp90 drives a molecular ‘clamp’ via transient dimerization of the N-terminal domains

  Chrisostomos Prodromou;Barry Panaretou;Barry Panaretou;Shahzad Chohan;Giuliano Siligardi

  651
  Citations

• Structural and Functional Analysis of the Middle Segment of Hsp90 Implications for ATP Hydrolysis and Client Protein and Cochaperone Interactions

  Philippe Meyer;Chrisostomos Prodromou;Bin Hu;Cara Vaughan

  589
  Citations

• Chaperoned Ubiquitylation-Crystal Structures of the Chip U Box E3 Ubiquitin Ligase and a Chip-Ubc13-Uev1A Complex

  Minghao Zhang;Mark Windheim;S. Mark Roe;Mark Peggie

  463
  Citations

• Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity

  James S Parker;S Mark Roe;David Barford

  446
  Citations

• Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex

  Rana Dajani;Elizabeth Fraser;S. Mark Roe;Margaret Yeo

  437
  Citations

• The mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)

  S.Mark Roe;Maruf M.U Ali;Philippe Meyer;Cara K Vaughan

  426
  Citations

• Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery.

  Philippe Meyer;Chrisostomos Prodromou;Chunyan Liao;Bin Hu

  389
  Citations

• Structural basis for recruitment of translesion DNA polymerase Pol IV/DinB to the β-clamp

  Karen A. Bunting;S.Mark Roe;Laurence H. Pearl

  323
  Citations

• Structural Basis for the Requirement of Additional Factors for MLL1 SET Domain Activity and Recognition of Epigenetic Marks

  Stacey M. Southall;Poon-Sheng Wong;Zain Odho;S. Mark Roe

  309
  Citations

• A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone

  C Prodromou;S.M Roe;P.W Piper;L.H. Pearl

  289
  Citations

• The Identification, Synthesis, Protein Crystal Structure and in Vitro Biochemical Evaluation of a New 3,4-Diarylpyrazole Class of Hsp90 Inhibitors.

  Kwai-Ming J. Cheung;Thomas P. Matthews;Karen James;Martin G. Rowlands

  282
  Citations

• Molecular basis for TPR domain‐mediated regulation of protein phosphatase 5

  Jing Yang;S. Mark Roe;Matthew J. Cliff;Mark A. Williams

  240
  Citations