World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
123
Citations
69274
World Ranking
547
National Ranking
348

Research.com Recognitions

  • 2021 - Fellow of the Mineralogical Society of America
  • 2021 - Distinguished Scientist Award, Mineralogical Society of America
  • 2009 - Fellow of the American Academy of Arts and Sciences
  • 2007 - Member of the National Academy of Sciences

Overview

David A. Agard is affiliated with the University of California, San Francisco in the United States. Their research primarily falls within the field of Biochemistry, Genetics and Molecular Biology, with a specific focus on Molecular Biology, Cell Biology, Structural Biology, Materials Chemistry, and Surfaces, Coatings and Films.

The main topics of David A. Agard's work include:

  • Advanced Electron Microscopy Techniques and Applications
  • Microtubule and mitosis dynamics
  • Heat shock proteins research
  • Enzyme Structure and Function
  • Electron and X-Ray Spectroscopy Techniques
  • Bacteriophages and microbial interactions
  • Protein Structure and Dynamics

They have frequently published in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Nature
  • Proceedings of the National Academy of Sciences
  • Journal of Biological Chemistry

Notable recent papers by David A. Agard include:

  • A SARS-CoV-2 protein interaction map reveals targets for drug repurposing, 2020, Nature
  • A molecular pore spans the double membrane of the coronavirus replication organelle, 2020, Science
  • A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • AreTomo: An integrated software package for automated marker-free, motion-corrected cryo-electron tomographic alignment and reconstruction, 2022, Journal of Structural Biology X
  • Structure of Hsp90-Hsp70-Hop-GR reveals the Hsp90 client-loading mechanism, 2021, Nature

Frequent collaborators include:

  • Yifan Cheng
  • Kliment A. Verba
  • Shawn Zheng
  • Chari M. Noddings
  • Feng Wang

David A. Agard has received several awards including the Distinguished Scientist Award from the Mineralogical Society of America in 2021, was named a Fellow of the Mineralogical Society of America the same year, and has been a Fellow of the American Academy of Arts and Sciences since 2009. They also became a Member of the National Academy of Sciences in 2007.

Best Publications

  • MotionCor2: Anisotropic Correction of Beam-Induced Motion for Improved Cryo-Electron Microscopy

    Shawn Q. Zheng;Eugene Palovcak;Jean Paul Armache;Kliment A. Verba

  • A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.

    David E. Gordon;Gwendolyn M. Jang;Mehdi Bouhaddou;Jiewei Xu

  • The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen

    Andrew K. Shiau;Danielle Barstad;Paula M. Loria;Lin Cheng

  • Microtubule nucleation by γ-tubulin complexes

    Justin M. Kollman;Andreas Merdes;Lionel Mourey;David A. Agard

  • Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM

    Xueming Li;Paul Mooney;Shawn Zheng;Shawn Zheng;Christopher R Booth

  • Three-Dimensional Resolution Doubling in Wide-Field Fluorescence Microscopy by Structured Illumination

    Mats G.L. Gustafsson;Lin Shao;Peter M. Carlton;C. J. Rachel Wang

  • Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

    Adam G. Larson;Daniel Elnatan;Madeline M. Keenen;Michael J. Trnka

  • Subdiffraction Multicolor Imaging of the Nuclear Periphery with 3D Structured Illumination Microscopy

    Lothar Schermelleh;Peter M. Carlton;Sebastian Haase;Lin Shao

  • Estrogen receptor pathways to AP-1.

    Peter J. Kushner;David A. Agard;Geoffrey L. Greene;Thomas S. Scanlan

  • Fluorescence microscopy in three dimensions.

    David A. Agard;Yasushi Hiraoka;Peter Shaw;John W. Sedat

  • Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E.

    Charles Wilson;Mark R. Wardell;Karl H. Weisgraber;Robert W. Mahley

  • Interphase chromosomes undergo constrained diffusional motion in living cells.

    W.F Marshall;A Straight;J.F Marko;J Swedlow

  • Microtubule nucleation by γ-tubulin-containing rings in the centrosome

    Michelle Moritz;Michael B. Braunfeld;John W. Sedat;Bruce Alberts

  • Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

    David E. Gordon;Joseph Hiatt;Mehdi Bouhaddou;Veronica V. Rezelj

  • Optical Sectioning Microscopy: Cellular Architecture in Three Dimensions

    D A Agard

  • Three-dimensional architecture of a polytene nucleus

    David A. Agard;John W. Sedat

  • I5M: 3D widefield light microscopy with better than 100 nm axial resolution.

    M. G. L. Gustafsson;D. A. Agard;J. W. Sedat

  • Structural Analysis of E. coli hsp90 Reveals Dramatic Nucleotide-Dependent Conformational Rearrangements

    Andrew K. Shiau;Seth F. Harris;Seth F. Harris;Daniel R. Southworth;David A. Agard

  • Structural studies of the scrapie prion protein by electron crystallography

    Holger Wille;Melissa D. Michelitsch;Vincent Guénebaut;Surachai Supattapone

  • Perturbation of Nuclear Architecture by Long-Distance Chromosome Interactions

    Abby F. Dernburg;Karl W. Broman;Jennifer C. Fung;Wallace F. Marshall

Frequent Co-Authors

John W. Sedat
John W. Sedat University of California, San Francisco
Yifan Cheng
Yifan Cheng University of California, San Francisco
Richard J. Spontak
Richard J. Spontak North Carolina State University
Wallace F. Marshall
Wallace F. Marshall University of California, San Francisco
Andrej Sali
Andrej Sali University of California, San Francisco
David Baker
David Baker University of Washington
Trisha N. Davis
Trisha N. Davis University of Washington
Yasushi Hiraoka
Yasushi Hiraoka Osaka University
Feng Wang
Feng Wang University of California, Berkeley
Jason R. Swedlow
Jason R. Swedlow University of Dundee

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