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Biology and Biochemistry

D-Index
73
Citations
17942
World Ranking
5967
National Ranking
2819

Overview

Gabriela Chiosis is affiliated with the Memorial Sloan Kettering Cancer Center in the United States. Their research spans several key areas within biochemistry, genetics, and molecular biology, with a strong focus on molecular and cell biology, as well as radiology, nuclear medicine, imaging, computational theory, mathematics, and immunology. Their work frequently addresses complex molecular mechanisms and cellular processes related to disease states.

The main topics of Gabriela Chiosis's research include:

  • Heat shock proteins research
  • Endoplasmic reticulum stress and disease
  • Bioinformatics and genomic networks
  • Computational drug discovery methods
  • Protein structure and dynamics
  • Alzheimer's disease research and treatments
  • Medical imaging techniques and applications

Gabriela Chiosis has contributed to notable scientific journals, with frequent publications in:

  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biomolecules
  • Cancer Research
  • Biomedicines

Their recent published papers include:

  • Structural and functional complexity of HSP90 in cellular homeostasis and disease, 2023, Nature Reviews Molecular Cell Biology
  • Gold/alpha-lactalbumin nanoprobes for the imaging and treatment of breast cancer, 2020, Nature Biomedical Engineering
  • The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction, 2020, Nature Communications
  • Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone, 2020, Cell Reports
  • Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation, 2023, Nature Communications

Gabriela Chiosis collaborates frequently with a range of researchers in their field. Prominent coauthors include:

  • Sahil Sharma
  • Chander Singh Digwal
  • Palak Panchal
  • Stephen D. Ginsberg
  • Anna Rodina

Gabriela Chiosis's research contributions reflect a multidisciplinary approach, integrating molecular biology techniques with computational methods and biomedical applications. Their scientific output highlights a consistent engagement with protein dynamics, stress-related cellular mechanisms, and innovative imaging methods in the context of disease research. This body of work contributes to a better understanding of cellular homeostasis and disorders at the molecular level.

Best Publications

  • Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function.

    Andrea D. Basso;Andrea D. Basso;David B. Solit;Gabriela Chiosis;Banabihari Giri

  • Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators

    Haley Hieronymus;Justin Lamb;Kenneth N. Ross;Xiao P. Peng;Xiao P. Peng

  • Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers.

    Komal Jhaveri;Tony Taldone;Shanu Modi;Gabriela Chiosis;Gabriela Chiosis

  • New Arylthioindoles: Potent Inhibitors of Tubulin Polymerization. 2. Structure−Activity Relationships and Molecular Modeling Studies

    Gabriella De Martino;Michael C. Edler;Giuseppe La Regina;Antonio Coluccia

  • Heterodimeric JAK–STAT activation as a mechanism of persistence to JAK2 inhibitor therapy

    Priya Koppikar;Neha Bhagwat;Outi Kilpivaara;Taghi Manshouri

  • BCR-ABL point mutants isolated from patients with imatinib mesylate–resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90

    Mercedes E. Gorre;Katharine Ellwood-Yen;Katharine Ellwood-Yen;Gabriela Chiosis;Gabriela Chiosis;Neal Rosen;Neal Rosen

  • Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models

    Eloisi Caldas-Lopes;Leandro Cerchietti;James H. Ahn;Cristina C. Clement

  • Targeting Hsp90: small-molecule inhibitors and their clinical development

    Tony Taldone;Alexander Gozman;Ronnie Maharaj;Gabriela Chiosis

  • A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells

    Gabriela Chiosis;Merna N Timaul;Brian Lucas;Pamela N Munster

  • Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies.

    Wenjie Luo;Fei Dou;Anna Rodina;Sophorn Chip

  • Development and application of Hsp90 inhibitors.

    David B. Solit;Gabriela Chiosis

  • Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms

    Raajit Rampal;Jihae Ahn;Omar Abdel-Wahab;Michelle Nahas

  • Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

    Kamalika Moulick;James H Ahn;Hongliang Zong;Anna Rodina

  • Hsp90: the vulnerable chaperone.

    Gabriela Chiosis;Maria Vilenchik;Joungnam Kim;David Solit

  • Heat shock protein 90 in neurodegenerative diseases

    Wenjie Luo;Weilin Sun;Tony Taldone;Anna Rodina

  • The epichaperome is an integrated chaperome network that facilitates tumour survival

    Anna Rodina;Tai Wang;Pengrong Yan;Erica DaGama Gomes

  • HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans

    Sachie Marubayashi;Priya Koppikar;Tony Taldone;Omar Abdel-Wahab

  • Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase.

    Gabriela Chiosis;Brian Lucas;Alexander Shtil;Henri Huezo

  • Hsp70 molecular chaperones: emerging roles in human disease and identification of small molecule modulators.

    Jeffrey L Brodsky;Gabriela Chiosis

  • Heterodimeric JAK-STAT Activation As a Mechanism of Persistence to JAK2 Inhibitor Therapy

    Neha Bhagwat;Priya Koppikar;Outi Kilpivaara;Taghi Manshouri

Frequent Co-Authors

Neal Rosen
Neal Rosen Memorial Sloan Kettering Cancer Center
Ari Melnick
Ari Melnick Cornell University
Jason S. Lewis
Jason S. Lewis Memorial Sloan Kettering Cancer Center
Steven M. Larson
Steven M. Larson Memorial Sloan Kettering Cancer Center
Ross L. Levine
Ross L. Levine Memorial Sloan Kettering Cancer Center
Hediye Erdjument-Bromage
Hediye Erdjument-Bromage New York University
Jeffrey L. Brodsky
Jeffrey L. Brodsky University of Pittsburgh
Zihai Li
Zihai Li The Ohio State University
David B. Solit
David B. Solit Memorial Sloan Kettering Cancer Center
Ethel Cesarman
Ethel Cesarman Cornell University

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