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D-Index & Metrics

Molecular Biology

D-Index
115
Citations
54912
World Ranking
303
National Ranking
182

Research.com Recognitions

  • 2025 - Member of the National Academy of Sciences
  • 2023 - Member, American Academy of Arts and Sciences
  • 2016 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Ali Shilatifard is a researcher affiliated with Northwestern University in the United States. Their work primarily focuses on the fields of Biochemistry, Genetics, and Molecular Biology, with significant contributions in Molecular Biology, Genetics, Surgery, Cancer Research, and Epidemiology.

Their research covers several main topics, including:

  • Genomics and Chromatin Dynamics
  • Epigenetics and DNA Methylation
  • Cancer-related gene regulation
  • Protein Degradation and Inhibitors
  • RNA modifications and cancer
  • RNA Research and Splicing
  • Ubiquitin and proteasome pathways

Ali Shilatifard has published numerous articles in a variety of scientific journals. Frequent publication venues include:

  • Science Advances
  • Molecular Cell
  • Neuro-Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Clinical Investigation

Their recent papers reflect a range of topics intersecting immunology, molecular biology, and disease research:

  • "Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia," 2021, Nature
  • "The roles of Polycomb repressive complexes in mammalian development and cancer," 2021, Nature Reviews Molecular Cell Biology
  • "Reevaluating the roles of histone-modifying enzymes and their associated chromatin modifications in transcriptional regulation," 2020, Nature Genetics
  • "Lung transplantation for patients with severe COVID-19," 2020, Science Translational Medicine
  • "COMPASS and SWI/SNF complexes in development and disease," 2020, Nature Reviews Genetics

Collaborative research is a part of their scientific activities, with frequent co-authors including:

  • Yuki Aoi
  • Andrea Piunti
  • Marc A. Morgan
  • Elizabeth T. Bartom
  • Emily J. Rendleman

Throughout their career, Ali Shilatifard has received recognition such as being named a Fellow of the American Association for the Advancement of Science (AAAS) in 2016.

Best Publications

  • Global landscape of protein complexes in the yeast Saccharomyces cerevisiae

    Nevan J. Krogan;Gerard Cagney;Gerard Cagney;Haiyuan Yu;Gouqing Zhong

  • An operational definition of epigenetics

    Shelley L. Berger;Tony Kouzarides;Ramin Shiekhattar;Ali Shilatifard

  • Chromatin Modifications by Methylation and Ubiquitination: Implications in the Regulation of Gene Expression

    Ali Shilatifard

  • Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis.

    Paul Andrew Reyfman;James McCauley Walter;Nikita Joshi;Kishore R. Anekalla

  • New nomenclature for chromatin-modifying enzymes.

    C. David Allis;Shelley L. Berger;Jacques Cote;Sharon R Dent

  • The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis.

    Ali Shilatifard

  • The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation.

    Nevan J. Krogan;Jim Dover;Adam Wood;Jessica Schneider

  • Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span.

    Alexander V. Misharin;Luisa Morales-Nebreda;Paul A. Reyfman;Carla M. Cuda

  • Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II.

    Nevan J. Krogan;Minkyu Kim;Amy Tong;Ashkan Golshani

  • Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8

    Karl W. Henry;Anastasia Wyce;Wan Sheng Lo;Laura J. Duggan

  • Covalent modifications of histones during development and disease pathogenesis.

    Sukesh R Bhaumik;Edwin Smith;Ali Shilatifard

  • Histone H2B Monoubiquitination Functions Cooperatively with FACT to Regulate Elongation by RNA Polymerase II

    Rushad Pavri;Bing Zhu;Guohong Li;Patrick Trojer

  • Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia.

    Rogan A Grant;Luisa Morales-Nebreda;Nikolay S Markov;Suchitra Swaminathan

  • COMPASS: A complex of proteins associated with a trithorax-related SET domain protein

    Trissa Miller;Nevan J. Krogan;Jim Dover;H. Erdjument-Bromage

  • Histone H4 lysine-16 acetylation regulates cellular lifespan

    Weiwei Dang;Kristan K. Steffen;Rocco Perry;Jean A. Dorsey

  • Methylation of Histone H3 by COMPASS Requires Ubiquitination of Histone H2B by Rad6

    Jim Dover;Jessica Schneider;Mary Anne Tawiah-Boateng;Adam Wood

  • The language of histone crosstalk.

    Jung Shin Lee;Edwin Smith;Ali Shilatifard

  • RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach.

    Nevan J. Krogan;Minkyu Kim;Seong Hoon Ahn;Guoqing Zhong

  • Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter.

    Adam Wood;Nevan J Krogan;Jim Dover;Jessica Schneider

  • AFF4, a Component of the ELL/P-TEFb Elongation Complex and a Shared Subunit of MLL Chimeras, Can Link Transcription Elongation to Leukemia

    Chengqi Lin;Edwin R. Smith;Hidehisa Takahashi;Ka Chun Lai

Frequent Co-Authors

Edwin R. Smith
Edwin R. Smith Northwestern University
Joan Weliky Conaway
Joan Weliky Conaway The University of Texas Southwestern Medical Center
Michael P. Washburn
Michael P. Washburn University of Kansas
Ronald C. Conaway
Ronald C. Conaway The University of Texas Southwestern Medical Center
Ramin Shiekhattar
Ramin Shiekhattar University of Miami
Laurence Florens
Laurence Florens Stowers Institute for Medical Research
Joel C. Eissenberg
Joel C. Eissenberg Saint Louis University
Nevan J. Krogan
Nevan J. Krogan University of California, San Francisco
Jack Greenblatt
Jack Greenblatt University of Toronto
C. David James
C. David James Northwestern University

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