World's Best Scientists 2026 revealed!
Jack Greenblatt

Jack Greenblatt

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Molecular Biology
Canada
2026

D-Index & Metrics

Molecular Biology

D-Index
114
Citations
52348
World Ranking
318
National Ranking
9

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in Canada Leader Award
  • 2025 - Research.com Molecular Biology in Canada Leader Award
  • 2023 - Research.com Molecular Biology in Canada Leader Award
  • 1992 - Fellow of the Royal Society of Canada Academy of Science

Overview

Jack Greenblatt is affiliated with the University of Toronto in Canada, specializing in Biochemistry, Genetics, and Molecular Biology. Their research primarily focuses on Molecular Biology, with additional work in Infectious Diseases, Immunology, Cancer Research, and Oncology. The main topics covered by their work include RNA modifications and cancer, RNA research and splicing, genomics and chromatin dynamics, epigenetics and DNA methylation, interferon and immune responses, cancer-related molecular mechanisms research, and SARS-CoV-2 and COVID-19 research.

The scientist's recent published papers include:

  • Nucleolar RNA polymerase II drives ribosome biogenesis, 2020, Nature
  • SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response, 2021, iScience
  • A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization, 2021, Nature Chemical Biology
  • A central chaperone-like role for 14-3-3 proteins in human cells, 2023, Molecular Cell
  • Discovery and significance of protein-protein interactions in health and disease, 2024, Cell

Frequent co-authors in Greenblatt's publications are:

  • Edyta Marcon
  • Syed Nabeel-Shah
  • Shuye Pu
  • Benjamin J. Blencowe
  • Hyunmin Lee

Greenblatt's work has been published repeatedly in several venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Cell
  • PLoS Pathogens
  • Zenodo (CERN European Organization for Nuclear Research)
  • Nature

Award recognition includes being named a Fellow of the Royal Society of Canada in 1992 by the Academy of Science.

Best Publications

  • Global landscape of protein complexes in the yeast Saccharomyces cerevisiae

    Nevan J. Krogan;Gerard Cagney;Gerard Cagney;Haiyuan Yu;Gouqing Zhong

  • Global Mapping of the Yeast Genetic Interaction Network

    Amy Hin Yan Tong;Guillaume Lesage;Gary D. Bader;Huiming Ding

  • A Bayesian networks approach for predicting protein-protein interactions from genomic data.

    Ronald Jansen;Haiyuan Yu;Dov Greenbaum;Yuval Kluger

  • Interaction network containing conserved and essential protein complexes in Escherichia coli

    Gareth Butland;José Manuel Peregrín-Alvarez;Joyce Li;Wehong Yang

  • The C-terminal domain of RNA polymerase II couples mRNA processing to transcription.

    Susan McCracken;Nova Fong;Krassimir Yankulov;Scott Ballantyne

  • Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map

    Sean R. Collins;Kyle M. Miller;Nancy L. Maas;Assen Roguev

  • Exploration of the Function and Organization of the Yeast Early Secretory Pathway through an Epistatic Miniarray Profile

    Maya Schuldiner;Sean R. Collins;Natalie J. Thompson;Vladimir Denic

  • Toward a Comprehensive Atlas of the Physical Interactome of Saccharomyces cerevisiae

    Sean R. Collins;Sean R. Collins;Patrick Kemmeren;Patrick Kemmeren;Xue-Chu Zhao;Jack F. Greenblatt

  • Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex.

    Michael Christopher Keogh;Siavash K. Kurdistani;Stephanie A. Morris;Seong Hoon Ahn

  • Navigating the Chaperone Network: An Integrative Map of Physical and Genetic Interactions Mediated by the Hsp90 Chaperone

    Rongmin Zhao;Mike Davey;Ya-Chieh Hsu;Pia Kaplanek

  • The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation.

    Nevan J. Krogan;Jim Dover;Adam Wood;Jessica Schneider

  • Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II.

    Nevan J. Krogan;Minkyu Kim;Amy Tong;Ashkan Golshani

  • Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIID

    K F Stringer;C J Ingles;J Greenblatt

  • A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1.

    Nevan J. Krogan;Michael-Christopher Keogh;Nira Datta;Chika Sawa

  • Exploration of essential gene functions via titratable promoter alleles

    Sanie Mnaimneh;Armaity P Davierwala;Jennifer Haynes;Jason Moffat

  • COMPASS: A complex of proteins associated with a trithorax-related SET domain protein

    Trissa Miller;Nevan J. Krogan;Jim Dover;H. Erdjument-Bromage

  • INO80 and γ-H2AX Interaction Links ATP-Dependent Chromatin Remodeling to DNA Damage Repair

    Ashby J. Morrison;Jessica Highland;Nevan J. Krogan;Ayelet Arbel-Eden

  • Methods for Measurement of Intermolecular NOEs by Multinuclear NMR Spectroscopy: Application to a Bacteriophage λ N-Peptide/boxB RNA Complex

    Catherine Zwahlen;Pascale Legault;Sébastien J. F. Vincent;Jack Greenblatt

  • The yeast Rat1 exonuclease promotes transcription termination by RNA polymerase II

    Minkyu Kim;Nevan J. Krogan;Lidia Vasiljeva;Oliver J. Rando

  • RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach.

    Nevan J. Krogan;Minkyu Kim;Seong Hoon Ahn;Guoqing Zhong

Frequent Co-Authors

Andrew Emili
Andrew Emili Boston University
Nevan J. Krogan
Nevan J. Krogan University of California, San Francisco
Cheryl H. Arrowsmith
Cheryl H. Arrowsmith Structural Genomics Consortium
Stephen Buratowski
Stephen Buratowski Harvard University
Shoshana J. Wodak
Shoshana J. Wodak Vrije Universiteit Brussel
Michael S. Kobor
Michael S. Kobor University of British Columbia
John Parkinson
John Parkinson University of Toronto
Jinrong Min
Jinrong Min Structural Genomics Consortium
Lori Frappier
Lori Frappier University of Toronto
Gerard Cagney
Gerard Cagney University College Dublin

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