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Patrick Cramer

Patrick Cramer

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Genetics and Molecular Biology
Germany
2024

D-Index & Metrics

Molecular Biology

D-Index
115
Citations
47305
World Ranking
311
National Ranking
27

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in Germany Leader Award
  • 2020 - Member of the National Academy of Sciences
  • 2017 - Member of Academia Europaea

Overview

Patrick Cramer is affiliated with the Max Planck Society in Germany and has a significant publication record primarily in the fields of Biochemistry, Genetics, and Molecular Biology. Their research spans multiple specialized subfields including Molecular Biology, Infectious Diseases, Plant Science, Animal Science and Zoology, and Cardiology and Cardiovascular Medicine.

The scientist's work focuses notably on several key research topics, which include:

  • RNA Research and Splicing
  • Genomics and Chromatin Dynamics
  • RNA and Protein Synthesis Mechanisms
  • RNA Modifications and Cancer
  • SARS-CoV-2 and COVID-19 Research
  • CRISPR and Genetic Engineering
  • Viral Gastroenteritis Research and Epidemiology

Patrick Cramer has contributed to numerous papers, with notable recent publications including:

  • "Structure of replicating SARS-CoV-2 polymerase" (2020), published in Nature
  • "Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis" (2021), published in Nature Structural & Molecular Biology
  • "Mechanism of SARS-CoV-2 polymerase stalling by remdesivir" (2021), published in Nature Communications
  • "Multi-particle cryo-EM refinement with M visualizes ribosome-antibiotic complex at 3.5 Å in cells" (2021), published in Nature Methods
  • "AlphaFold2 and the future of structural biology" (2021), published in Nature Structural & Molecular Biology

Their research outputs frequently appear in select publication venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Structural & Molecular Biology
  • Molecular Cell
  • Nature
  • Nature Communications

Patrick Cramer has worked extensively with various co-authors, with frequent collaborators such as:

  • Christian Dienemann
  • Michael Lidschreiber
  • Henning Urlaub
  • Dimitry Tegunov
  • Lucas Farnung

In recognition of their scientific contributions, Patrick Cramer was elected as a Member of the National Academy of Sciences in 2020 and as a Member of Academia Europaea in 2017.

Best Publications

  • RNA velocity of single cells

    Gioele La Manno;Gioele La Manno;Ruslan Soldatov;Amit Zeisel;Amit Zeisel;Emelie Braun;Emelie Braun

  • Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution.

    Patrick Cramer;David A. Bushnell;Roger D. Kornberg

  • Structural Basis of Transcription: An RNA Polymerase II Elongation Complex at 3.3 Å Resolution

    Averell L. Gnatt;Patrick Cramer;T. Jianhua Fu;David A. Bushnell

  • Structure of replicating SARS-CoV-2 polymerase.

    Hauke S. Hillen;Goran Kokic;Lucas Farnung;Christian Dienemann

  • Architecture of RNA polymerase II and implications for the transcription mechanism.

    Patrick Cramer;David A. Bushnell;Jianhua Fu;Averell L. Gnatt

  • Organization and regulation of gene transcription.

    Patrick Cramer

  • RNA polymerase II clustering through carboxy-terminal domain phase separation

    Marc Boehning;Claire Dugast-Darzacq;Marija Rankovic;Anders S Hansen

  • Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis.

    Florian Kabinger;Carina Stiller;Jana Schmitzová;Christian Dienemann

  • Uniform transitions of the general RNA polymerase II transcription complex.

    Andreas Mayer;Michael Lidschreiber;Matthias Siebert;Kristin Leike

  • Complete RNA Polymerase II Elongation Complex Structure and Its Interactions with NTP and TFIIS

    Hubert Kettenberger;Karim-Jean Armache;Patrick Cramer

  • Mechanism of SARS-CoV-2 polymerase stalling by remdesivir.

    Goran Kokic;Hauke S. Hillen;Hauke S. Hillen;Dimitry Tegunov;Christian Dienemann

  • TT-seq maps the human transient transcriptome

    Björn Schwalb;Margaux Michel;Benedikt Zacher;Katja Frühauf

  • Structural basis of transcription initiation by RNA polymerase II

    Sarah Sainsbury;Carrie A Bernecky;Patrick Cramer

  • A structural perspective of CTD function

    Anton Meinhart;Tomislav Kamenski;Sabine Hoeppner;Sonja Baumli

  • Conservation between the RNA Polymerase I, II, and III Transcription Initiation Machineries

    Alessandro Vannini;Patrick Cramer

  • Architecture of the RNA polymerase II–TFIIF complex revealed by cross-linking and mass spectrometry

    Zhuo Angel Chen;Anass Jawhari;Lutz Fischer;Claudia Buchen

  • Dynamic transcriptome analysis measures rates of mRNA synthesis and decay in yeast

    Christian Miller;Björn Schwalb;Kerstin Maier;Daniel Schulz

  • Architecture of the RNA Polymerase II-TFIIS Complex and Implications for mRNA Cleavage

    Hubert Kettenberger;Karim-Jean Armache;Patrick Cramer

  • Structure of eukaryotic RNA polymerases.

    Patrick Cramer;Karim J. Armache;Sonja Baumli;Stefan Benkert

  • Structural basis of RNA polymerase II backtracking, arrest and reactivation

    Alan C. M. Cheung;Patrick Cramer

Frequent Co-Authors

Henning Urlaub
Henning Urlaub University of Göttingen
Julien Gagneur
Julien Gagneur Technical University of Munich
Roger D. Kornberg
Roger D. Kornberg Stanford University
Jussi Taipale
Jussi Taipale University of Cambridge
Franz Herzog
Franz Herzog Ludwig-Maximilians-Universität München
Johannes Söding
Johannes Söding Max Planck Society
Thomas Carell
Thomas Carell Ludwig-Maximilians-Universität München
Michael Thomm
Michael Thomm University of Regensburg
Juri Rappsilber
Juri Rappsilber Technical University of Berlin

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