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Genetics and Molecular Biology
Finland
2024

D-Index & Metrics

Genetics

D-Index
79
Citations
42661
World Ranking
1613
National Ranking
211

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in Finland Leader Award
  • 2023 - Research.com Genetics and Molecular Biology in Finland Leader Award
  • 2022 - Research.com Genetics and Molecular Biology in Finland Leader Award
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Jussi Taipale is affiliated with the University of Cambridge in the United Kingdom, where their research focuses on molecular biology, genetics, and medicine. Their work spans several subfields including molecular biology, genetics, oncology, surgery, and obstetrics and gynecology.

Their primary research topics include genomics and chromatin dynamics, RNA research and splicing, RNA and protein synthesis mechanisms, CRISPR and genetic engineering, RNA modifications and cancer, pancreatic function and diabetes, and diabetes alongside associated disorders.

Among recent publications of note are:

  • Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function, 2020, Nature
  • A comprehensive library of human transcription factors for cell fate engineering, 2020, Nature Biotechnology
  • Genetic and Epigenetic Characteristics of Inflammatory Bowel Disease-Associated Colorectal Cancer, 2021, Gastroenterology
  • Sequence determinants of human gene regulatory elements, 2022, Nature Genetics
  • Systematic analysis of binding of transcription factors to noncoding variants, 2021, Nature

Jussi Taipale frequently collaborates with several researchers, including Biswajyoti Sahu, Lauri A. Aaltonen, Teemu Kivioja, Eevi Kaasinen, and Kimmo Palin.

They have published extensively in venues such as bioRxiv (Cold Spring Harbor Laboratory), Zenodo (CERN European Organization for Nuclear Research), Nature, Nature Biotechnology, and Gastroenterology.

Jussi Taipale holds the distinction of being a Member of the European Molecular Biology Organization (EMBO).

Best Publications

  • The Human Transcription Factors.

    Samuel A. Lambert;Arttu Jolma;Laura F. Campitelli;Pratyush K. Das

  • The Hedgehog and Wnt signalling pathways in cancer

    Jussi Taipale;Philip A. Beachy

  • Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.

    James K. Chen;Jussi Taipale;Michael K. Cooper;Philip A. Beachy

  • Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

    Jussi Taipale;James K. Chen;Michael K. Cooper;Baolin Wang

  • Hedgehog: functions and mechanisms

    Markku Varjosalo;Jussi Taipale

  • DNA-Binding Specificities of Human Transcription Factors

    Arttu Jolma;Jian Yan;Thomas Whitington;Jarkko Toivonen

  • Growth factors in the extracellular matrix.

    Jussi Taipale;Jorma Keski-Oja

  • Small molecule modulation of Smoothened activity.

    James K. Chen;Jussi Taipale;Keith E. Young;Tapan Maiti

  • Counting absolute numbers of molecules using unique molecular identifiers

    Teemu Kivioja;Anna Vähärautio;Anna Vähärautio;Kasper Karlsson;Martin Bonke

  • Cardiovascular Failure in Mouse Embryos Deficient in VEGF Receptor-3

    Daniel J. Dumont;Lotta Jussila;Jussi Taipale;Athina Lymboussaki

  • Impact of cytosine methylation on DNA binding specificities of human transcription factors.

    Yimeng Yin;Ekaterina Morgunova;Arttu Jolma;Eevi Kaasinen

  • CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response.

    Emma Haapaniemi;Emma Haapaniemi;Sandeep Botla;Jenna Persson;Bernhard Schmierer

  • Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade

    David M. Berman;Sunil S. Karhadkar;Andrew R. Hallahan;Joel I. Pritchard

  • Patched acts catalytically to suppress the activity of Smoothened

    J. Taipale;M. K. Cooper;T. Maiti;P. A. Beachy

  • VEGFR-3 and Its Ligand VEGF-C Are Associated with Angiogenesis in Breast Cancer

    Reija Valtola;Petri Salven;Päivi Heikkilä;Jussi Taipale

  • MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas.

    Netta Mäkinen;Miika Mehine;Jaana Tolvanen;Eevi Kaasinen

  • Genome-Wide Analysis of ETS-Family DNA-Binding In Vitro and In Vivo

    Gong-Hong Wei;Gwenael Badis;Michael F. Berger;Teemu Kivioja;Teemu Kivioja

  • Latent transforming growth factor-beta 1 associates to fibroblast extracellular matrix via latent TGF-beta binding protein

    Jussi Taipale;Kohei Miyazono;Carl-Henrik Heldin;Jorma Keski-Oja

  • Comprehensive evaluation of coding region point mutations in microsatellite‐unstable colorectal cancer

    Johanna Kondelin;Kari Salokas;Lilli Saarinen;Kristian Ovaska

  • Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial Share Alike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resultingworkunderthesameorsimilarlicensetothisone.Theworkmustbeattributedbacktotheoriginalauthorand commercial use is not permitted without specific permission.

    Gong-Hong Wei;Gwenael Badis;Michael F Berger;Teemu Kivioja

Frequent Co-Authors

Lauri A. Aaltonen
Lauri A. Aaltonen University of Helsinki
Markku Varjosalo
Markku Varjosalo University of Helsinki
Jukka-Pekka Mecklin
Jukka-Pekka Mecklin University of Jyväskylä
Jorma Keski-Oja
Jorma Keski-Oja University of Helsinki
Heikki Järvinen
Heikki Järvinen University of Helsinki
Philip A. Beachy
Philip A. Beachy Stanford University
Esko Ukkonen
Esko Ukkonen University of Helsinki
Kari Alitalo
Kari Alitalo University of Helsinki
Ari Ristimäki
Ari Ristimäki University of Helsinki
Richard S. Houlston
Richard S. Houlston Institute of Cancer Research

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