D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Genetics and Molecular Biology D-index 75 Citations 34,407 150 World Ranking 1222 National Ranking 9

Research.com Recognitions

Awards & Achievements

Member of the European Molecular Biology Organization (EMBO)

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Genetics

Jussi Taipale focuses on Transcription factor, Genetics, Cell biology, Gene and DNA. His research integrates issues of Wnt signaling pathway, Gene expression, Genome, Computational biology and Transcription in his study of Transcription factor. His Gene expression research is multidisciplinary, relying on both Chromatin, Regulation of gene expression, Human genome and Zinc finger.

His Cell biology research includes elements of Cell cycle and Cell. His research on Gene frequently connects to adjacent areas such as Mediator. His DNA study frequently links to other fields, such as Chromatin immunoprecipitation.

His most cited work include:

  • Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened (1222 citations)
  • The Hedgehog and Wnt signalling pathways in cancer (1190 citations)
  • Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine (1167 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of investigation include Transcription factor, Genetics, Cell biology, Gene and Computational biology. He combines subjects such as Chromatin, DNA, Transcription and Human genome with his study of Transcription factor. Jussi Taipale has researched Human genome in several fields, including Systematic evolution of ligands by exponential enrichment and Zinc finger.

His work deals with themes such as Cancer cell and Cell cycle, which intersect with Cell biology. His study on Gene is mostly dedicated to connecting different topics, such as Cell. His biological study spans a wide range of topics, including CRISPR, RNA, Genome, Cell type and Binding selectivity.

He most often published in these fields:

  • Transcription factor (70.17%)
  • Genetics (55.04%)
  • Cell biology (52.52%)

What were the highlights of his more recent work (between 2018-2021)?

  • Transcription factor (70.17%)
  • Computational biology (48.74%)
  • Gene (62.61%)

In recent papers he was focusing on the following fields of study:

His main research concerns Transcription factor, Computational biology, Gene, Cell biology and Transcription. His work carried out in the field of Transcription factor brings together such families of science as Phenotype, Promoter, Cell type and Functional genomics. His Computational biology study combines topics from a wide range of disciplines, such as Cytoplasm, CRISPR, RNA, Rna protein and Messenger RNA.

His Gene study combines topics in areas such as Developmental biology and Modelling biological systems. His Cell biology research is multidisciplinary, incorporating elements of Histone octamer, Nucleosome, Gene expression, Cellular differentiation and Carcinogenesis. Jussi Taipale has included themes like Chromatin and Human genome in his Transcription study.

Between 2018 and 2021, his most popular works were:

  • Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function (43 citations)
  • Population-scale testing can suppress the spread of COVID-19 (37 citations)
  • Impact of constitutional TET2 haploinsufficiency on molecular and clinical phenotype in humans. (31 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Mutation

The scientist’s investigation covers issues in Computational biology, RNA, Cytoplasm, Messenger RNA and RNA splicing. His Computational biology research includes themes of Primary cell, Gene, Developmental biology and Induced pluripotent stem cell. His RNA study incorporates themes from HEK 293 cells and DNA-binding protein.

The study incorporates disciplines such as AU-rich element, RNA-binding protein, RNase P and Binding selectivity in addition to Cytoplasm.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

The Hedgehog and Wnt signalling pathways in cancer

Jussi Taipale;Philip A. Beachy.
Nature (2001)

1757 Citations

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

James K. Chen;Jussi Taipale;Michael K. Cooper;Philip A. Beachy.
Genes & Development (2002)

1595 Citations

Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins.

Marika J Karkkainen;Paula Haiko;Kirsi Sainio;Juha Partanen.
Nature Immunology (2004)

1519 Citations

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

Jussi Taipale;James K. Chen;Michael K. Cooper;Baolin Wang.
Nature (2000)

1465 Citations

Hedgehog: functions and mechanisms

Markku Varjosalo;Jussi Taipale.
Genes & Development (2008)

1251 Citations

Growth factors in the extracellular matrix.

Jussi Taipale;Jorma Keski‐Oja.
The FASEB Journal (1997)

1105 Citations

Cardiovascular Failure in Mouse Embryos Deficient in VEGF Receptor-3

Daniel J. Dumont;Lotta Jussila;Jussi Taipale;Athina Lymboussaki.
Science (1998)

1074 Citations

Small molecule modulation of Smoothened activity.

James K. Chen;Jussi Taipale;Keith E. Young;Tapan Maiti.
Proceedings of the National Academy of Sciences of the United States of America (2002)

1021 Citations

DNA-Binding Specificities of Human Transcription Factors

Arttu Jolma;Jian Yan;Thomas Whitington;Jarkko Toivonen.
Cell (2013)

993 Citations

Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade

David M. Berman;Sunil S. Karhadkar;Andrew R. Hallahan;Joel I. Pritchard.
Science (2002)

988 Citations

Best Scientists Citing Jussi Taipale

Kari Alitalo

Kari Alitalo

University of Helsinki

Publications: 224

Philip A. Beachy

Philip A. Beachy

Stanford University

Publications: 63

Daniel B. Rifkin

Daniel B. Rifkin

New York University

Publications: 58

Mathieu Lupien

Mathieu Lupien

Princess Margaret Cancer Centre

Publications: 52

Bing Ren

Bing Ren

University of California, San Diego

Publications: 48

Jorma Keski-Oja

Jorma Keski-Oja

University of Helsinki

Publications: 47

Norbert Perrimon

Norbert Perrimon

Harvard University

Publications: 47

Michael Detmar

Michael Detmar

École Polytechnique Fédérale de Lausanne

Publications: 46

Lauri A. Aaltonen

Lauri A. Aaltonen

University of Helsinki

Publications: 46

Tatiana V. Petrova

Tatiana V. Petrova

Ludwig Cancer Research

Publications: 45

Seppo Ylä-Herttuala

Seppo Ylä-Herttuala

University of Eastern Finland

Publications: 45

Juha Kere

Juha Kere

University of Helsinki

Publications: 43

Ian Tomlinson

Ian Tomlinson

University of Birmingham

Publications: 38

Matthew L. Freedman

Matthew L. Freedman

Harvard University

Publications: 38

Andrew P. McMahon

Andrew P. McMahon

University of Southern California

Publications: 36

Richard S. Houlston

Richard S. Houlston

Institute of Cancer Research

Publications: 36

Profile was last updated on December 6th, 2021.
Research.com Ranking is based on data retrieved from the Microsoft Academic Graph (MAG).
The ranking d-index is inferred from publications deemed to belong to the considered discipline.

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