Cheryl A. Janson

Overview

Best Publications

• Novel subunit-subunit interactions in the structure of glutamine synthetase.

  Robert J. Almassy;Cheryl A. Janson;R. Hamlin;N. H. Xuong

  380
  Citations

• Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality.

  Dennis Lee;Scott A. Long;Jerry L. Adams;George Chan

  323
  Citations

• Structure of and kinetic channelling in bifunctional dihydrofolate reductase-thymidylate synthase.

  Daniel R. Knighton;Chen-Chen Kan;Eleanor Howland;Cheryl A. Janson

  271
  Citations

• Refined structures of beta-ketoacyl-acyl carrier protein synthase III.

  Xiayang Qiu;Cheryl A Janson;Ward W Smith;Martha Head

  240
  Citations

• 4-Aryl-1,2,3-triazole: a novel template for a reversible methionine aminopeptidase 2 inhibitor, optimized to inhibit angiogenesis in vivo.

  Lara S. Kallander;Qing Lu;Wenfang Chen;Thaddeus Tomaszek

  238
  Citations

• Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors.

  Xiayang Qiu;Cheryl A. Janson;Ward W. Smith;Susan M. Green

  233
  Citations

• Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinones.

  Stephen E. Webber;Ted M. Bleckman;John Attard;Judith G. Deal

  229
  Citations

• Discovery of a Novel and Potent Class of FabI-Directed Antibacterial Agents

  David J. Payne;William H. Miller;Valerie Berry;John Brosky

  217
  Citations

• Structure of the C-terminally truncated human ProMMP9, a gelatin-binding matrix metalloproteinase

  Patricia A. Elkins;Yen Sen Ho;Ward W. Smith;Cheryl A. Janson

  212
  Citations

• Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK.

  Mark A. Seefeld;William H. Miller;Kenneth A. Newlander;Walter J. Burgess

  209
  Citations

• Unique fold and active site in cytomegalovirus protease

  Xiayang Qiu;Jeffrey S. Culp;Anthony G. DiLella;Brian Hellmig

  205
  Citations

• Refined atomic model of glutamine synthetase at 3.5 A resolution.

  M M Yamashita;R J Almassy;C A Janson;D Cascio

  204
  Citations

• Crystal structure of beta-ketoacyl-acyl carrier protein synthase III. A key condensing enzyme in bacterial fatty acid biosynthesis.

  Xiayang Qiu;Cheryl A. Janson;Alex K. Konstantinidis;Silas Nwagwu

  199
  Citations

• Design of potent and selective human cathepsin K inhibitors that span the active site

  S K Thompson;S M Halbert;M J Bossard;T A Tomaszek

  179
  Citations

• Crystal structure and substrate specificity of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus.

  Xiayang Qiu;Anthony E. Choudhry;Cheryl A. Janson;Michael Grooms

  172
  Citations

• Stereochemical mechanism of action for thymidylate synthase based on the X-ray structure of the covalent inhibitory ternary complex with 5-fluoro-2′-deoxyuridylate and 5,10-methylenetetrahydrofolate

  D.A. Matthews;J.E. Villafranca;C.A. Janson;W.W. Smith

  158
  Citations

• Molecular basis for triclosan activity involves a flipping loop in the active site.

  Xiayang Qiu;Cheryl A. Janson;Robert I. Court;Martin G. Smyth

  154
  Citations

• Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI).

  William H. Miller;Mark A. Seefeld;Kenneth A. Newlander;Irene N. Uzinskas

  153
  Citations

• Crystal structure of human osteoclast cathepsin K complex with E-64.

  Baoguang Zhao;Cheryl A. Janson;Bernard Y. Amegadzie;Karla D'Alessio

  152
  Citations

• 1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI).

  Dirk A Heerding;George Chan;Walter E DeWolf;Andrew P Fosberry

  151
  Citations

• Identification of a Series of Tricyclic Natural Products as Potent Broad-Spectrum Inhibitors of Metallo-β-Lactamases

  David J. Payne;Juan Antonio Hueso-Rodríguez;Helen Boyd;Néstor O. Concha

  142
  Citations