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Chemistry

D-Index
64
Citations
12822
World Ranking
8143
National Ranking
2347

Research.com Recognitions

  • 2019 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2001 - Fellow of Alfred P. Sloan Foundation

Overview

Peter J. Tonge is affiliated with Stony Brook University in the United States. Their research spans several interrelated fields, primarily focusing on biochemistry, genetics, and molecular biology, alongside significant work in medicine. The subfields of their study include molecular biology, cellular and molecular neuroscience, plant science, organic chemistry, and genetics.

The scientist's research topics prominently cover photoreceptor and optogenetics research, light effects on plants, and photosynthetic processes and mechanisms. Additional focal areas include bioluminescence and chemiluminescence research, antibiotic resistance in bacteria, antibiotics pharmacokinetics and efficacy, as well as chronic lymphocytic leukemia research.

Tonge has published extensively, with their work appearing frequently in several scientific journals. Their main publication venues include:

  • ACS Infectious Diseases
  • Journal of Medicinal Chemistry
  • ACS Chemical Biology
  • Journal of the American Chemical Society
  • bioRxiv (Cold Spring Harbor Laboratory)

Selected recent research papers authored or co-authored by Tonge include:

  • "Unraveling the Mechanism of a LOV Domain Optogenetic Sensor: A Glutamine Lever Induces Unfolding of the Jα Helix" (2020), published in ACS Chemical Biology
  • "High Accuracy Prediction of PROTAC Complex Structures" (2023), published in Journal of the American Chemical Society
  • "Correlating Drug-Target Residence Time and Post-antibiotic Effect: Insight into Target Vulnerability" (2020), published in ACS Infectious Diseases
  • "Photophysics of the Blue Light Using Flavin Domain" (2022), published in Accounts of Chemical Research
  • "Functional dynamics of a single tryptophan residue in a BLUF protein revealed by fluorescence spectroscopy" (2020), published in Scientific Reports

Frequent collaborators in their work include Jinnette Tolentino Collado, András Lukács, Stephen R. Meech, James N. Iuliano, and Stephen G. Walker.

Peter J. Tonge has received recognition through awards such as Fellow of the American Association for the Advancement of Science (AAAS) in 2019 and Fellow of the Alfred P. Sloan Foundation in 2001.

Best Publications

  • Drug–target residence time: critical information for lead optimization

    Hao Lu;Peter J Tonge

  • The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: adduct affinity and drug resistance.

    Richa Rawat;Adrian Whitty;Peter J. Tonge

  • Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis.

    Sarah L. Kinnings;Nina Liu;Nancy Buchmeier;Peter J. Tonge

  • Inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis, by triclosan and isoniazid.

    Sapan L. Parikh;Guoping Xiao;Peter J. Tonge

  • High Affinity InhA Inhibitors with Activity against Drug-Resistant Strains of Mycobacterium tuberculosis

    Todd J. Sullivan;James J. Truglio;James J. Truglio;Melissa E. Boyne;Polina Novichenok

  • Inhibitors of FabI, an enzyme drug target in the bacterial fatty acid biosynthesis pathway.

    Hao Lu;Peter J. Tonge

  • Structural basis and mechanism of enoyl reductase inhibition by triclosan.

    Michael J Stewart;Sapan Parikh;Guoping Xiao;Peter J Tonge

  • Drug–Target Kinetics in Drug Discovery

    Peter J. Tonge

  • A Machine Learning-Based Method To Improve Docking Scoring Functions and Its Application to Drug Repurposing

    Sarah L. Kinnings;Nina Liu;Peter J. Tonge;Richard M. Jackson

  • Observation of excited-state proton transfer in green fluorescent protein using ultrafast vibrational spectroscopy.

    Deborah Stoner-Ma;Andrew A. Jaye;Pavel Matousek;Michael Towrie

  • A slow, tight binding inhibitor of InhA, the enoyl-acyl carrier protein reductase from Mycobacterium tuberculosis.

    Sylvia R. Luckner;Nina Liu;Christopher W. am Ende;Peter J. Tonge

  • Probing the ground state structure of the green fluorescent protein chromophore using Raman spectroscopy.

    Alasdair F. Bell;Xiang He;Rebekka M. Wachter;Peter J. Tonge

  • Roles of tyrosine 158 and lysine 165 in the catalytic mechanism of InhA, the enoyl-ACP reductase from Mycobacterium tuberculosis.

    Sapan Parikh;Daniel P. Moynihan;Guoping Xiao;Peter J. Tonge

  • Novel Trisubstituted Benzimidazoles, Targeting Mtb FtsZ, as a New Class of Antitubercular Agents

    Kunal Kumar;Divya Awasthi;Seung-Yub Lee;Ilaria Zanardi

  • Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli.

    Deniz Tasdemir;Bülent Topaloglu;Remo Perozzo;Reto Brun

  • Translating slow-binding inhibition kinetics into cellular and in vivo effects

    Grant K Walkup;Zhiping You;Philip L Ross;Eleanor K H Allen

  • Inhibition of the Bacterial Enoyl Reductase FabI by Triclosan: A Structure−Reactivity Analysis of FabI Inhibition by Triclosan Analogues†

    Sharada Sivaraman;Todd J. Sullivan;Francis Johnson;Polina Novichenok

  • Structure of Acyl Carrier Protein Bound to FabI, the FASII Enoyl Reductase from Escherichia coli

    Salma Rafi;Polina Novichenok;Subramaniapillai Kolappan;Xujie Zhang

  • Structure-activity studies of the inhibition of FabI, the enoyl reductase from Escherichia coli, by triclosan: kinetic analysis of mutant FabIs.

    Sharada Sivaraman;Jacque Zwahlen;Alasdair F Bell;Lizbeth Hedstrom

  • Direct inhibitors of InhA are active against Mycobacterium tuberculosis

    Ujjini H. Manjunatha;Ujjini H. Manjunatha;Srinivasa P. S. Rao;Ravinder Reddy Kondreddi;Christian G. Noble

  • Isotopic labeling and normal-mode analysis of a model green fluorescent protein chromophore

    Xiang He;and Alasdair F. Bell;Peter J. Tonge

Frequent Co-Authors

Caroline Kisker
Caroline Kisker University of Würzburg
Stephen R. Meech
Stephen R. Meech University of East Anglia
Michael Towrie
Michael Towrie Rutherford Appleton Laboratory
Carlos Simmerling
Carlos Simmerling Stony Brook University
Christoph A. Sotriffer
Christoph A. Sotriffer University of Würzburg
Rui Fausto
Rui Fausto University of Coimbra
Kevin H. Gardner
Kevin H. Gardner City University of New York
Martin J. Mueller
Martin J. Mueller University of Würzburg
Vernon E. Anderson
Vernon E. Anderson Case Western Reserve University
Joanna S. Fowler
Joanna S. Fowler Brookhaven National Laboratory

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