Rebecca C. Wade focuses on Protein structure, Active site, Molecular dynamics, Biochemistry and Stereochemistry. The concepts of her Protein structure study are interwoven with issues in Cysteine, Cysteine synthase, Peptide sequence, Cell biology and Lipid bilayer. Her Active site research incorporates elements of Ligand, Ionic bonding, Protein Data Bank, Substrate and Cytochrome.
Her Molecular dynamics research is included under the broader classification of Computational chemistry. Her work deals with themes such as Directed evolution, Dehalogenase, Haloalkane dehalogenase and Binding site, which intersect with Stereochemistry. Rebecca C. Wade has researched Binding site in several fields, including Docking and DNA-binding protein.
Her primary areas of study are Biochemistry, Molecular dynamics, Stereochemistry, Biophysics and Protein structure. Many of her research projects under Biochemistry are closely connected to Thymidylate synthase with Thymidylate synthase, tying the diverse disciplines of science together. Her study in Molecular dynamics is interdisciplinary in nature, drawing from both Chemical physics, Crystallography and Biological system.
Her research integrates issues of Binding energy, Haloalkane dehalogenase, Binding site and Active site in her study of Stereochemistry. Her Binding site research integrates issues from Plasma protein binding, Ligand and Ligand. Her work investigates the relationship between Protein structure and topics such as Computational biology that intersect with problems in Kinetics and Drug discovery.
Her primary scientific interests are in Molecular dynamics, Biophysics, Cell biology, Computational biology and Biological system. Her studies deal with areas such as Chemical physics, Lipid bilayer, Dissociation and Binding pocket as well as Molecular dynamics. Her Biophysics research incorporates themes from Membrane, Receptor–ligand kinetics and Histone.
The study incorporates disciplines such as Druggability, Natural product, Trypanosoma brucei and Kinetics in addition to Computational biology. Her work in Druggability covers topics such as Protein dynamics which are related to areas like Binding site. Her Biological system research includes themes of Drug target and Drug discovery.
Rebecca C. Wade spends much of her time researching Molecular dynamics, Cell biology, Drug target, Chromatosome and Histone. Her Molecular dynamics research is multidisciplinary, incorporating perspectives in Proteins metabolism, Biological system, Kinetics and Ligand. Her research in Cell biology intersects with topics in Trans-splicing, Polyadenylation, RNA, Protein domain and Trypanosoma brucei.
Her study in Drug target is interdisciplinary in nature, drawing from both Biophysics, In silico, Force field and Binding energy. Her study on Biophysics is intertwined with other disciplines of science such as Linker and Brownian dynamics. Her Histone research is multidisciplinary, incorporating elements of Computational biology and Sequence.
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Electrostatics and diffusion of molecules in solution: simulations with the University of Houston Brownian dynamics program
Jeffry D. Madura;James M. Briggs;Rebecca C. Wade;Malcolm E. Davis.
Computer Physics Communications (1995)
New hydrogen-bond potentials for use in determining energetically favorable binding sites on molecules of known structure.
David N. A. Boobbyer;Peter J. Goodford;Peter M. McWhinnie;Rebecca C. Wade.
Journal of Medicinal Chemistry (1989)
Simulation of the diffusional association of barnase and barstar.
R.R. Gabdoulline;R.C. Wade.
Biophysical Journal (1997)
The ins and outs of cytochrome P450s
Vlad Cojocaru;Peter J. Winn;Rebecca C. Wade.
Biochimica et Biophysica Acta (2007)
Improving the Continuum Dielectric Approach to Calculating pKas of Ionizable Groups in Proteins
Eugene Demchuk;Rebecca C. Wade.
The Journal of Physical Chemistry (1996)
Prediction of drug binding affinities by comparative binding energy analysis
Ortiz Ar;Pisabarro Mt;Gago F;Wade Rc.
Journal of Medicinal Chemistry (1995)
Redesigning Dehalogenase Access Tunnels as a Strategy for Degrading an Anthropogenic Substrate.
Martina Pavlova;Martin Klvana;Zbynek Prokop;Radka Chaloupkova.
Nature Chemical Biology (2009)
Protein-protein association: investigation of factors influencing association rates by brownian dynamics simulations.
Razif R. Gabdoulline;Rebecca C. Wade.
Journal of Molecular Biology (2001)
How do substrates enter and products exit the buried active site of cytochrome P450cam? 1. Random expulsion molecular dynamics investigation of ligand access channels and mechanisms.
Susanna K Lüdemann;Valère Lounnas;Rebecca C Wade.
Journal of Molecular Biology (2000)
Biomolecular diffusional association.
Razif R. Gabdoulline;Rebecca C. Wade.
Current Opinion in Structural Biology (2002)
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