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Biology and Biochemistry

D-Index
84
Citations
29754
World Ranking
3278
National Ranking
1663

Overview

James Shorter is affiliated with the University of Pennsylvania in the United States and has a significant body of work spanning biochemistry, genetics, molecular biology, and medicine. Their research primarily focuses on molecular biology, neurology, genetics, cell biology, and aging, with a notable emphasis on the mechanisms related to RNA and protein regulation.

The scientist's recent publications include:

  • TDP-43 represses cryptic exon inclusion in the FTD-ALS gene UNC13A, 2022, Nature
  • FUS and TDP-43 Phases in Health and Disease, 2021, Trends in Biochemical Sciences
  • TDP-43 condensation properties specify its RNA-binding and regulatory repertoire, 2021, Cell
  • C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy, 2020, Science Translational Medicine
  • Higher-order organization of biomolecular condensates, 2021, Open Biology

The main topics covered in their work include:

  • RNA Research and Splicing
  • Amyotrophic Lateral Sclerosis Research
  • Neurogenetic and Muscular Disorders Research
  • Heat shock proteins research
  • RNA modifications and cancer
  • Prion Diseases and Protein Misfolding
  • RNA and protein synthesis mechanisms

Frequently collaborating with other researchers, James Shorter works closely with colleagues including Charlotte M. Fare, Sua Myong, Hana M. Odeh, Ryan R. Cupo, and Lin Guo. These collaborations have contributed to a diverse set of studies affecting several aspects of molecular and cellular biology.

Their research has been published extensively in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biophysical Journal
  • The FASEB Journal
  • Cell Reports
  • Molecular Cell

James Shorter's body of work is anchored in the study of molecular processes involving RNA and protein interactions, particularly regarding neurodegenerative diseases. Their contributions span both fundamental and applied aspects of biochemistry and molecular biology, with relevance to neurological disorders and cellular mechanisms underlying these conditions.

Best Publications

  • Protein Phase Separation: A New Phase in Cell Biology.

    Steven Boeynaems;Steven Boeynaems;Simon Alberti;Nicolas L. Fawzi;Tanja Mittag

  • Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

    Hong Joo Kim;Nam Chul Kim;Yong Dong Wang;Emily A. Scarborough

  • Stress granules as crucibles of ALS pathogenesis

    Yun R. Li;Yun R. Li;Oliver D. King;James Shorter;Aaron D. Gitler

  • TDP-43 Is Intrinsically Aggregation-prone, and Amyotrophic Lateral Sclerosis-linked Mutations Accelerate Aggregation and Increase Toxicity

    Brian S. Johnson;David Snead;Jonathan J. Lee;J. Michael McCaffery

  • The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease

    Oliver D. King;Aaron D. Gitler;James Shorter

  • Neurodegenerative disease: models, mechanisms, and a new hope.

    Aaron D. Gitler;Paraminder Dhillon;James Shorter

  • The molecular language of membraneless organelles

    Edward Gomes;James Shorter

  • The Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis

    Aaron D. Gitler;Brooke J. Bevis;James Shorter;Katherine E. Strathearn

  • Prions as adaptive conduits of memory and inheritance

    James Shorter;Susan Lindquist

  • A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways.

    Hemmo H Meyer;James G Shorter;Joachim Seemann;Darryl Pappin

  • Molecular Determinants and Genetic Modifiers of Aggregation and Toxicity for the ALS Disease Protein FUS/TLS

    Zhihui Sun;Zamia Diaz;Xiaodong Fang;Michael P. Hart

  • A yeast functional screen predicts new candidate ALS disease genes

    Julien Couthouis;Michael P. Hart;James Shorter;Mariely DeJesus-Hernandez

  • RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43.

    Jacob R. Mann;Amanda M. Gleixner;Jocelyn C. Mauna;Edward Gomes

  • Golgi Architecture and Inheritance

    James Shorter;Graham Warren

  • Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains

    Lin Guo;Hong Joo Kim;Hejia Wang;John Monaghan

  • Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization

    Leeanne McGurk;Edward Gomes;Lin Guo;Jelena Mojsilovic-Petrovic

  • Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death.

    Fatima Gasset-Rosa;Shan Lu;Haiyang Yu;Cong Chen

  • RNA-binding proteins with prion-like domains in health and disease

    Alice Ford Harrison;James Shorter

  • GRASP55, a second mammalian GRASP protein involved in the stacking of Golgi cisternae in a cell-free system

    James Shorter;Rose Watson;Maria‐Eleni Giannakou;Mairi Clarke

  • The Mammalian Disaggregase Machinery: Hsp110 Synergizes with Hsp70 and Hsp40 to Catalyze Protein Disaggregation and Reactivation in a Cell-Free System

    James Shorter

Frequent Co-Authors

Aaron D. Gitler
Aaron D. Gitler Stanford University
Graham Warren
Graham Warren Medical University of Vienna
Oliver D. King
Oliver D. King University of Massachusetts Chan Medical School
Nancy M. Bonini
Nancy M. Bonini University of Pennsylvania
Andrzej Joachimiak
Andrzej Joachimiak Argonne National Laboratory
Kim A. Caldwell
Kim A. Caldwell University of Alabama
J. Paul Taylor
J. Paul Taylor St. Jude Children's Research Hospital
Guy A. Caldwell
Guy A. Caldwell University of Alabama
Robert G. Kalb
Robert G. Kalb Northwestern University

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