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D-Index & Metrics

Genetics

D-Index
74
Citations
25822
World Ranking
1944
National Ranking
891

Research.com Recognitions

  • 2014 - Fellow of the American Academy of Arts and Sciences
  • 2012 - Member of the National Academy of Sciences
  • 2011 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Nancy M. Bonini is affiliated with the University of Pennsylvania in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine. Within these broad areas, their work focuses extensively on Molecular Biology and Neurology, with additional interests in Physiology, Cancer Research, and Epidemiology.

The scientist's main research topics include:

  • RNA Research and Splicing
  • RNA modifications and cancer
  • Alzheimer's disease research and treatments
  • Histone Deacetylase Inhibitors Research
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Mitochondrial Function and Pathology
  • Traumatic Brain Injury and Neurovascular Disturbances

Recent publication venues where Nancy M. Bonini has frequently contributed are:

  • Nature
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Aging Cell
  • Nature Genetics
  • Innovation in Aging

The scientist's recent papers reflect a multidisciplinary approach towards neurodegenerative diseases and cellular pathology. Key papers include:

  • "An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer's disease," 2020, Nature Genetics
  • "Senescent glia link mitochondrial dysfunction and lipid accumulation," 2024, Nature
  • "m1A in CAG repeat RNA binds to TDP-43 and induces neurodegeneration," 2023, Nature
  • "Dynamic neural and glial responses of a head-specific model for traumatic brain injury in Drosophila," 2020, Proceedings of the National Academy of Sciences
  • "Glial AP1 is activated with aging and accelerated by traumatic brain injury," 2021, Nature Aging

Frequent coauthors collaborating with Nancy M. Bonini include:

  • China N. Byrns
  • Alexandra E. Perlegos
  • Ananth Srinivasan
  • Oksana Shcherbakova
  • Shelley L. Berger

Throughout their career, Nancy M. Bonini has been recognized by several prestigious institutions. They were elected a Member of the National Academy of Sciences in 2012, named a Fellow of the American Association for the Advancement of Science (AAAS) in 2011, and became a Fellow of the American Academy of Arts and Sciences in 2014.

Best Publications

  • α-Synuclein Blocks ER-Golgi Traffic and Rab1 Rescues Neuron Loss in Parkinson's Models

    Antony A. Cooper;Aaron D. Gitler;Anil Cashikar;Cole M. Haynes

  • Chaperone Suppression of α-Synuclein Toxicity in a Drosophila Model for Parkinson's Disease

    Pavan K. Auluck;H. Y. Edwin Chan;John Q. Trojanowski;Virginia M.-Y. Lee

  • Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS

    Andrew C. Elden;Hyung Jun Kim;Michael P. Hart;Alice S. Chen-Plotkin

  • Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

    John M. Warrick;H. Y.Edwin Chan;Gladys L. Gray-Board;Yaohui Chai

  • Expanded Polyglutamine Protein Forms Nuclear Inclusions and Causes Neural Degeneration in Drosophila

    John M Warrick;Henry L Paulson;Gladys L Gray-Board;Quang T Bui

  • Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila

    Shermali Gunawardena;Lu-Shiun Her;Richard G. Brusch;Robert A. Laymon

  • The eyes absent gene: Genetic control of cell survival and differentiation in the developing Drosophila eye

    Nancy M. Bonini;William M. Leiserson;Seymour Benzer

  • Analysis of the Role of Heat Shock Protein (Hsp) Molecular Chaperones in Polyglutamine Disease

    Yaohui Chai;Stacia L. Koppenhafer;Nancy M. Bonini;Henry L. Paulson

  • Drosophila as a Model for Human Neurodegenerative Disease

    Julide Bilen;Nancy M Bonini

  • Reward learning in normal and mutant Drosophila

    Bruce L. Tempel;Nancy Bonini;Douglas R. Dawson;William G. Quinn

  • A yeast functional screen predicts new candidate ALS disease genes

    Julien Couthouis;Michael P. Hart;James Shorter;Mariely DeJesus-Hernandez

  • The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila

    Nan Liu;Michael Landreh;Michael Landreh;Kajia Cao;Masashi Abe

  • Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

    Hyung-Jun Kim;Alya R Raphael;Eva S LaDow;Leeanne McGurk

  • Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization

    Leeanne McGurk;Edward Gomes;Lin Guo;Jelena Mojsilovic-Petrovic

  • Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila

    H.Y. Edwin Chan;John M. Warrick;Gladys L. Gray-Board;Henry L. Paulson

  • Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease.

    Marc Meulener;Alexander J. Whitworth;Cecilia E. Armstrong-Gold;Patrizia Rizzu

  • Recruitment and the Role of Nuclear Localization in Polyglutamine-mediated Aggregation

    Matthew K. Perez;Henry L. Paulson;Sagun J. Pendse;Sarah J. Saionz

  • RNA toxicity is a component of ataxin-3 degeneration in Drosophila

    Ling-Bo Li;Zhenming Yu;Xiuyin Teng;Nancy M. Bonini

  • Pharmacological prevention of Parkinson disease in Drosophila.

    Pavan K Auluck;Nancy M Bonini

  • DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function

    Ling-Yang Hao;Benoit I. Giasson;Nancy M. Bonini

Frequent Co-Authors

Virginia M.-Y. Lee
Virginia M.-Y. Lee University of Pennsylvania
John Q. Trojanowski
John Q. Trojanowski University of Pennsylvania
Aaron D. Gitler
Aaron D. Gitler Stanford University
Vivianna M. Van Deerlin
Vivianna M. Van Deerlin University of Pennsylvania
Robert G. Kalb
Robert G. Kalb Northwestern University
Henry L. Paulson
Henry L. Paulson University of Michigan–Ann Arbor
Shelley L. Berger
Shelley L. Berger University of Pennsylvania
Benoit I. Giasson
Benoit I. Giasson University of Florida
James Shorter
James Shorter University of Pennsylvania
F. Brad Johnson
F. Brad Johnson University of Pennsylvania

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