What is he best known for?
The fields of study he is best known for:
- Internal medicine
- Gene
- Disease
His primary scientific interests are in Pathology, Spinal and bulbar muscular atrophy, Internal medicine, Cell biology and Amyotrophic lateral sclerosis.
The various areas that Gen Sobue examines in his Pathology study include Central nervous system disease and Spinal cord.
His Spinal and bulbar muscular atrophy research is multidisciplinary, relying on both Heat shock protein, Receptor, Polyglutamine tract, Genetically modified mouse and Atrophy.
His Internal medicine research is multidisciplinary, incorporating perspectives in Gastroenterology, Endocrinology, Surgery and Cardiology.
As a part of the same scientific family, Gen Sobue mostly works in the field of Cell biology, focusing on Mutant and, on occasion, Ubiquitin ligase.
As part of one scientific family, Gen Sobue deals mainly with the area of Amyotrophic lateral sclerosis, narrowing it down to issues related to the Motor neuron, and often Neurodegeneration.
His most cited work include:
- A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome) (585 citations)
- CREB-binding protein sequestration by expanded polyglutamine (498 citations)
- Progression and prognosis in multiple system atrophy: an analysis of 230 Japanese patients. (424 citations)
What are the main themes of his work throughout his whole career to date?
His primary areas of investigation include Pathology, Internal medicine, Amyotrophic lateral sclerosis, Spinal and bulbar muscular atrophy and Endocrinology.
His work in Pathology tackles topics such as Spinal cord which are related to areas like Anatomy.
Gen Sobue interconnects Gastroenterology, Surgery, Chronic inflammatory demyelinating polyneuropathy and Cardiology in the investigation of issues within Internal medicine.
His Amyotrophic lateral sclerosis research incorporates elements of Genetics, Gene and Neuroscience.
His Spinal and bulbar muscular atrophy study integrates concerns from other disciplines, such as Neurodegeneration, Motor neuron, Polyglutamine tract, Cell biology and Genetically modified mouse.
Gen Sobue frequently studies issues relating to Amyloidosis and Transthyretin.
He most often published in these fields:
- Pathology (28.57%)
- Internal medicine (25.36%)
- Amyotrophic lateral sclerosis (15.89%)
What were the highlights of his more recent work (between 2015-2021)?
- Pathology (28.57%)
- Internal medicine (25.36%)
- Amyotrophic lateral sclerosis (15.89%)
In recent papers he was focusing on the following fields of study:
Gen Sobue mostly deals with Pathology, Internal medicine, Amyotrophic lateral sclerosis, Neuroscience and Chronic inflammatory demyelinating polyneuropathy.
Pathogenesis, Transthyretin, Skin biopsy, Leukoencephalopathy and Amyloidosis are the core of his Pathology study.
His work in Internal medicine covers topics such as Placebo which are related to areas like Adverse effect.
His Amyotrophic lateral sclerosis study combines topics from a wide range of disciplines, such as Frontotemporal lobar degeneration, Frontotemporal dementia, Genetics, Gene and Spinal and bulbar muscular atrophy.
Neuroscience is closely attributed to Parkinson's disease in his work.
Gen Sobue has included themes like Polyneuropathy and Polyradiculoneuropathy in his Chronic inflammatory demyelinating polyneuropathy study.
Between 2015 and 2021, his most popular works were:
- Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial (325 citations)
- Exosome secretion is a key pathway for clearance of pathological TDP-43. (133 citations)
- Subcutaneous immunoglobulin for maintenance treatment in chronic inflammatory demyelinating polyneuropathy (PATH): a randomised, double-blind, placebo-controlled, phase 3 trial (117 citations)
In his most recent research, the most cited papers focused on:
- Internal medicine
- Gene
- Disease
His primary areas of study are Pathology, Amyotrophic lateral sclerosis, Internal medicine, Cell biology and Neuroscience.
His Amyotrophic lateral sclerosis research includes themes of Frontotemporal lobar degeneration, Mutation, Gene, Anatomy and RNA-binding protein.
His research in Internal medicine intersects with topics in Endocrinology, Surgery, Cardiology, Placebo and Spinal and bulbar muscular atrophy.
His Endocrinology research is multidisciplinary, relying on both Neuromuscular junction and Acetylcholine receptor.
His work deals with themes such as Gastroenterology, Creatinine and Bioinformatics, which intersect with Spinal and bulbar muscular atrophy.
His biological study spans a wide range of topics, including HSF1, Microglia and TAF15.
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