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Neuroscience
Japan
2026
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Medicine
Japan
2023

D-Index & Metrics

Neuroscience

D-Index
121
Citations
60337
World Ranking
372
National Ranking
4

Medicine

D-Index
121
Citations
60427
World Ranking
3581
National Ranking
69

Research.com Recognitions

  • 2026 - Research.com Neuroscience in Japan Leader Award
  • 2025 - Research.com Neuroscience in Japan Leader Award
  • 2023 - Research.com Medicine in Japan Leader Award

Overview

Gen Sobue is affiliated with Aichi Medical University in Japan and has an extensive publication record primarily focused on neurological diseases and related biomedical research. Their work spans several main fields of study including Medicine and Neuroscience, with notable contributions especially within the subfields of Neurology, Genetics, Molecular Biology, Cellular and Molecular Neuroscience, and Cognitive Neuroscience.

The primary topics covered in Sobue's research encompass Amyotrophic Lateral Sclerosis Research, Neurogenetic and Muscular Disorders Research, mechanisms and treatments of Parkinson's Disease, Functional Brain Connectivity Studies, Genetic Neurodegenerative Diseases, Peripheral Neuropathies and Disorders, and Neurological diseases and metabolism.

Sobue has published multiple papers in various high-profile journals and venues. Their frequently appearing publication venues include:

  • Neurology
  • Journal of Neurology Neurosurgery & Psychiatry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Clinical Neurophysiology
  • Parkinsonism & Related Disorders

Selected recent papers authored by Sobue include:

  • "Amyotrophic lateral sclerosis" (2022) published in The Lancet
  • "YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology" (2020) published in Nature Communications
  • "Differential clinicopathologic features of EGPA-associated neuropathy with and without ANCA" (2020) published in Neurology
  • "Efficacy and Safety of Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis" (2022) published in JAMA Neurology
  • "ALS is a multistep process in South Korean, Japanese, and Australian patients" (2020) published in Neurology

Throughout Sobue's career, several researchers have frequently collaborated with them. These frequent coauthors include:

  • Masahisa Katsuno
  • Hirohisa Watanabe
  • Masashi Aoki
  • Kazuhiro Hara
  • Kazuya Kawabata

Gen Sobue's research record demonstrates a focus on neurodegenerative diseases, particularly amyotrophic lateral sclerosis, as well as related neurological and genetic disorders. The work covers molecular and clinical investigations contributing to the understanding of disease mechanisms and potential therapeutic approaches.

Best Publications

  • Amyotrophic lateral sclerosis

    Unknown

  • Amyotrophic lateral sclerosis

    Unknown

  • Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS.

    Unknown

  • A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)

    Hiroshi Inoue;Yukio Tanizawa;Jon Wasson;Philip Behn

  • Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial

    Koji Abe;Masashi Aoki;Shoji Tsuji;Yasuto Itoyama

  • A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ

    Yuichi Hashimoto;Takako Niikura;Hirohisa Tajima;Takashi Yasukawa

  • Progression and prognosis in multiple system atrophy: an analysis of 230 Japanese patients.

    Hirohisa Watanabe;Yufuko Saito;Shinichi Terao;Tetsuo Ando

  • CREB-binding protein sequestration by expanded polyglutamine

    Alexander McCampbell;J. Paul Taylor;Addis A. Taye;Jon Robitschek

  • The wide spectrum of clinical manifestations in Sjögren's syndrome-associated neuropathy

    Keiko Mori;Masahiro Iijima;Haruki Koike;Naoki Hattori

  • Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy.

    Masahisa Katsuno;Hiroaki Adachi;Akito Kume;Mei Li

  • Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent.

    Koki Fujimori;Mitsuru Ishikawa;Asako Otomo;Naoki Atsuta

  • 17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration.

    Masahiro Waza;Hiroaki Adachi;Masahisa Katsuno;Makoto Minamiyama

  • Retinoic-acid-concentration-dependent acquisition of neural cell identity during in vitro differentiation of mouse embryonic stem cells

    Yohei Okada;Takuya Shimazaki;Gen Sobue;Hideyuki Okano

  • Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy

    Mei Li;S. Miwa;Y. Kobayashi;Y. Kobayashi;D. E. Merry

  • Long-read sequencing identifies GGC repeat expansions in NOTCH2NLC associated with neuronal intranuclear inclusion disease.

    Jun Sone;Satomi Mitsuhashi;Atsushi Fujita;Takeshi Mizuguchi

  • X-linked recessive bulbospinal neuronopathy. A clinicopathological study.

    Gen Sobue;Yoshio Hashizume;Eiichiro Mukai;Masaaki Hirayama

  • Mutations in COQ2 in familial and sporadic multiple-system atrophy the multiple-system atrophy research collaboration

    Jun Mitsui;Takashi Matsukawa;Hiroyuki Ishiura;Yoko Fukuda;Yoko Fukuda

  • Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy

    Masahisa Katsuno;Hiroaki Adachi;Manabu Doyu;Makoto Minamiyama

  • Confirmatory double-blind, parallel-group, placebo-controlled study of efficacy and safety of edaravone (MCI-186) in amyotrophic lateral sclerosis patients

    Koji Abe;Yasuto Itoyama;Gen Sobue;Shoji Tsuji

  • Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3, and GDNF) and their receptors (p75NGFR, trkA, trkB, and trkC) in the adult human peripheral nervous system and nonneural tissues.

    Yamamoto M;Sobue G;Yamamoto K;Terao S

  • Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract.

    Yasushi Kobayashi;Akito Kume;Mei Li;Manabu Doyu

  • Heat Shock Protein 70 Chaperone Overexpression Ameliorates Phenotypes of the Spinal and Bulbar Muscular Atrophy Transgenic Mouse Model by Reducing Nuclear-Localized Mutant Androgen Receptor Protein

    Hiroaki Adachi;Masahisa Katsuno;Makoto Minamiyama;Chen Sang

  • Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

    Makoto Minamiyama;Masahisa Katsuno;Hiroaki Adachi;Masahiro Waza

Frequent Co-Authors

Masahisa Katsuno
Masahisa Katsuno Nagoya University
Fumiaki Tanaka
Fumiaki Tanaka Yokohama City University
Hiroaki Adachi
Hiroaki Adachi University of East Anglia
Shinji Naganawa
Shinji Naganawa Nagoya University
Satoshi Kuwabara
Satoshi Kuwabara Chiba University
Nobutaka Hattori
Nobutaka Hattori Juntendo University
Shoji Tsuji
Shoji Tsuji University of Tokyo
David R. Cornblath
David R. Cornblath Johns Hopkins University School of Medicine
David E Pleasure
David E Pleasure University of California, Davis
Koji Abe
Koji Abe Okayama University

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