John S. Mort

Research.com Recognitions

• 2023 - Research.com Biology and Biochemistry in Canada Leader Award

Overview

Best Publications

• Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment.

  R. Coulombe;P. Grochulski;J. Sivaraman;R. Ménard

  456
  Citations

• The role of aggrecan in normal and osteoarthritic cartilage

  Peter J Roughley;John S Mort

  347
  Citations

• Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro.

  C E Hughes;B Caterson;A J Fosang;P J Roughley

  327
  Citations

• Role of the occluding loop in cathepsin B activity.

  Chantal Illy;Omar Quraishi;Omar Quraishi;Jing Wang;Enrico Purisima

  326
  Citations

• Aggrecan degradation in human intervertebral disc and articular cartilage.

  Robert Sztrolovics;Mauro Alini;Peter J. Roughley;John S. Mort

  311
  Citations

• Maturation of human procathepsin B. Proenzyme activation and proteolytic processing of the precursor to the mature proteinase, in vitro, are primarily unimolecular processes.

  L Mach;J S Mort;J Glössl

  259
  Citations

• Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.

  Chris B. Little;Carl R. Flannery;Clare E. Hughes;John S. Mort

  259
  Citations

• Potency and selectivity of the cathepsin L propeptide as an inhibitor of cysteine proteases.

  Euridice Carmona;Éric Dufour;Céline Plouffe;Sachiko Takebe

  257
  Citations

• Potent slow-binding inhibition of cathepsin B by its propeptide.

  Fox T;de Miguel E;Mort Js;Storer Ac

  252
  Citations

• Rat procathepsin B. Proteolytic processing to the mature form in vitro.

  A D Rowan;P Mason;L Mach;J S Mort

  245
  Citations

• Myeloid-related proteins S100A8/S100A9 regulate joint inflammation and cartilage destruction during antigen-induced arthritis

  P.L.E.M. van Lent;L.C. Grevers;A.B. Blom;A.W. Sloetjes

  241
  Citations

• Structure of rat procathepsin B: model for inhibition of cysteine protease activity by the proregion

  Miroslaw Cygler;J Sivaraman;Pawel Grochulski;René Coulombe

  238
  Citations

• Mutations in WNT1 are a cause of osteogenesis imperfecta

  Somayyeh Fahiminiya;Jacek Majewski;John Mort;Pierre Moffatt

  227
  Citations

• Articular cartilage and changes in arthritis: matrix degradation.

  John S Mort;Caron J Billington

  222
  Citations

• Extracellular presence of the lysosomal proteinase cathepsin B in rheumatoid synovium and its activity at neutral pH.

  J S Mort;J S Mort;A D Recklies;A R Poole

  219
  Citations

• Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll-like receptor 4.

  Rik F. P. Schelbergen;Arjen B. Blom;Martijn H. J. van den Bosch;Annet Slöetjes

  209
  Citations

• Increased collagen and aggrecan degradation with age in the joints of Timp3−/− mice

  Solmaz Sahebjam;Rama Khokha;John S. Mort

  197
  Citations

• Non-proteoglycan forms of biglycan increase with age in human articular cartilage

  P J Roughley;R J White;M C Magny;J Liu

  191
  Citations

• Autocatalytic Processing of Recombinant Human Procathepsin L CONTRIBUTION OF BOTH INTERMOLECULAR AND UNIMOLECULAR EVENTS IN THE PROCESSING OF PROCATHEPSIN L IN VITRO

  Robert Ménard;Euridice Carmona;Sachiko Takebe;Éric Dufour

  181
  Citations

• Degradation of proteoglycan aggregate by a cartilage metalloproteinase. Evidence for the involvement of stromelysin in the generation of link protein heterogeneity in situ.

  Q Nguyen;G Murphy;P J Roughley;J S Mort

  156
  Citations