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Biology and Biochemistry

D-Index
68
Citations
13874
World Ranking
7932
National Ranking
273

Overview

Frank Beier is affiliated with the University of Western Ontario in Canada. Their research primarily focuses on the fields of medicine, with particular attention to rheumatology, molecular biology, pharmacology, surgery, and oncology.

The scientist's work centers on several main topics, including:

  • Osteoarthritis Treatment and Mechanisms
  • Inflammatory mediators and NSAID effects
  • Total Knee Arthroplasty Outcomes
  • Cell Adhesion Molecules Research
  • Knee injuries and reconstruction techniques
  • Cytokine Signaling Pathways and Interactions
  • Cancer-related molecular mechanisms research

Beier has contributed extensively to scientific literature, with frequent publications in the following venues:

  • Journal of Biological Chemistry
  • Osteoarthritis and Cartilage
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Arthritis Research & Therapy
  • Nature Reviews Rheumatology

Among recent papers authored or co-authored by Beier are:

  • "Targeting cartilage EGFR pathway for osteoarthritis treatment" (2021), published in Science Translational Medicine
  • "Interplay between genetics and epigenetics in osteoarthritis" (2020), published in Nature Reviews Rheumatology
  • "Global Deletion of Pannexin 3 Resulting in Accelerated Development of Aging-Induced Osteoarthritis in Mice" (2021), published in Arthritis & Rheumatology
  • "EGFR Signaling Is Required for Maintaining Adult Cartilage Homeostasis and Attenuating Osteoarthritis Progression" (2020), published in Journal of Bone and Mineral Research
  • "Expansion of myeloid-derived suppressor cells contributes to metabolic osteoarthritis through subchondral bone remodeling" (2021), published in Arthritis Research & Therapy

Frequent collaborators in Beier's research include:

  • Lila M. Gierasch
  • F. Peter Guengerich
  • Ruma Banerjee
  • Roger Colbran
  • Peter Cresswell

Best Publications

  • Fluorouracil, Leucovorin, and Irinotecan Plus Cetuximab Treatment and RAS Mutations in Colorectal Cancer

    Eric Van Cutsem;Heinz Josef Lenz;Claus Henning Köhne;Volker Heinemann

  • Prognostic and Predictive Relevance of Primary Tumor Location in Patients With RAS Wild-Type Metastatic Colorectal Cancer Retrospective Analyses of the CRYSTAL and FIRE-3 Trials

    Sabine Tejpar;Sebastian Stintzing;Fortunato Ciardiello;Josep Tabernero

  • RhoA/ROCK Signaling Regulates Sox9 Expression and Actin Organization during Chondrogenesis

    Anita Woods;Guoyan Wang;Frank Beier

  • Regulation of chondrocyte differentiation by the actin cytoskeleton and adhesive interactions.

    Anita Woods;Guoyan Wang;Frank Beier

  • Global analyses of gene expression in early experimental osteoarthritis.

    C. T. G. Appleton;V. Pitelka;J. Henry;F. Beier

  • FOLFOX4 plus cetuximab treatment and RAS mutations in colorectal cancer

    C. Bokemeyer;C.H. Kohne;F. Ciardiello;H.J. Lenz

  • Cartilage biology in osteoarthritis—lessons from developmental biology

    Andrew A. Pitsillides;Frank Beier

  • RhoA/ROCK signaling regulates chondrogenesis in a context-dependent manner.

    Anita Woods;Frank Beier

  • Forced mobilization accelerates pathogenesis: characterization of a preclinical surgical model of osteoarthritis

    C Thomas G Appleton;David D McErlain;David D McErlain;Vasek Pitelka;Neil Schwartz

  • CCN2 Is Necessary for Adhesive Responses to Transforming Growth Factor-β1 in Embryonic Fibroblasts

    Xu Shi-wen;Lee Anne Stanton;Laura Kennedy;Daphne Pala

  • Mouse models of osteoarthritis: modelling risk factors and assessing outcomes

    Hang Fang;Frank Beier

  • Identification of the cyclin D1 gene as a target of activating transcription factor 2 in chondrocytes

    Frank Beier;Richard J. Lee;Allison C. Taylor;Richard G. Pestell

  • MAP kinases in chondrocyte differentiation

    Lee-Anne Stanton;T.Michael Underhill;Frank Beier

  • Early Changes of Articular Cartilage and Subchondral Bone in The DMM Mouse Model of Osteoarthritis.

    Hang Fang;Lisi Huang;Ian Welch;Chris Norley

  • p38 MAP kinase signalling is required for hypertrophic chondrocyte differentiation.

    Lee-Anne Stanton;Shalev Sabari;Arthur V. Sampaio;T. Michael Underhill

  • TGFβ and PTHrP Control Chondrocyte Proliferation by Activating Cyclin D1 Expression

    Frank Beier;Zenobia Ali;Dereck Mok;Allison C. Taylor

  • RhoA/ROCK signaling suppresses hypertrophic chondrocyte differentiation.

    Guoyan Wang;Anita Woods;Shalev Sabari;Luca Pagnotta

  • Biology and pathology of rho GTPase, PI-3 kinase-Akt, and MAP kinase signaling pathways in chondrocytes

    Frank Beier;Richard F. Loeser

  • Microarray analyses of gene expression during chondrocyte differentiation identifies novel regulators of hypertrophy.

    Claudine G. James;C. Thomas G. Appleton;Veronica Ulici;T. Michael Underhill;T. Michael Underhill

  • Chondrocyte hypertrophy in skeletal development, growth, and disease.

    Margaret Man Ger Sun;Frank Beier

Frequent Co-Authors

John S. Mort
John S. Mort McGill University
T. Michael Underhill
T. Michael Underhill University of British Columbia
James L. Henry
James L. Henry McMaster University
Steven B. Abramson
Steven B. Abramson New York University
Elizabeth R. Gillies
Elizabeth R. Gillies University of Western Ontario
Dale W. Laird
Dale W. Laird University of Western Ontario
Andrew A. Pitsillides
Andrew A. Pitsillides Royal Veterinary College
Andrew Leask
Andrew Leask University of Saskatchewan
Daniel B. Rifkin
Daniel B. Rifkin New York University
James R. Woodgett
James R. Woodgett Lunenfeld-Tanenbaum Research Institute

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