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D-Index & Metrics

Biology and Biochemistry

D-Index
74
Citations
23032
World Ranking
5523
National Ranking
204

Overview

Andrew Leask is affiliated with the University of Saskatchewan in Canada and has contributed significantly to research in the areas of biochemistry, genetics, molecular biology, and medicine. Their work primarily focuses on molecular biology, pathology, forensic medicine, genetics, immunology, and cell biology.

Leask's research covers various topics within biomedical sciences, including:

  • Connective Tissue Growth Factor Research
  • Systemic Sclerosis and Related Diseases
  • Hippo pathway signaling and YAP/TAZ
  • Biomarkers in Disease Mechanisms
  • Wnt/β-catenin signaling in development and cancer
  • Dermatologic Treatments and Research
  • Cell Adhesion Molecules Research

The scientist has published extensively in several journals, with frequent appearances in:

  • Journal of Cell Communication and Signaling
  • Matrix Biology
  • Lara D. Veeken
  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)

Among the recent papers by Andrew Leask are:

  • "The Matrix Revolution: Matricellular Proteins and Restructuring of the Cancer Microenvironment" (2020) published in Cancer Research
  • "A CTGF-YAP Regulatory Pathway Is Essential for Angiogenesis and Barriergenesis in the Retina" (2020) published in iScience
  • "Conjunction junction, what's the function? CCN proteins as targets in fibrosis and cancers" (2020) published in American Journal of Physiology-Cell Physiology
  • "Verteporfin inhibits the persistent fibrotic phenotype of lesional scleroderma dermal fibroblasts" (2021) published in Journal of Cell Communication and Signaling
  • "Epithelial Vasopressin Type-2 Receptors Regulate Myofibroblasts by a YAP-CCN2-Dependent Mechanism in Polycystic Kidney Disease" (2020) published in Journal of the American Society of Nephrology

Leask collaborates regularly with several frequent co-authors, including:

  • Richard Stratton
  • Pratyusha Chitturi
  • Angha Naik
  • A. A. Fadl
  • Shiwen Xu

Best Publications

  • TGF-beta signaling and the fibrotic response.

    Andrew Leask;David J. Abraham

  • All in the CCN family: essential matricellular signaling modulators emerge from the bunker.

    Andrew Leask;David J. Abraham

  • Potential Therapeutic Targets for Cardiac Fibrosis TGFβ, Angiotensin, Endothelin, CCN2, and PDGF, Partners in Fibroblast Activation

    Andrew Leask

  • CTGF and SMADs, Maintenance of Scleroderma Phenotype Is Independent of SMAD Signaling

    Alan Holmes;David J. Abraham;Susan Sa;Xu Shiwen

  • Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy?

    Ingrid E Blom;Roel Goldschmeding;Andrew Leask

  • Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis

    Xu Shi-Wen;Andrew Leask;David Abraham

  • Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.

    Xu Shi-Wen;Yunliang Chen;Christopher P. Denton;Mark Eastwood

  • Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts.

    Andrew Leask;Alan Holmes;Carol M. Black;David J. Abraham

  • Getting to the Heart of the Matter: New Insights Into Cardiac Fibrosis

    Andrew Leask

  • Alopecia Universalis Associated with a Mutation in the Human hairless Gene

    Wasim Ahmad;Muhammad Faiyaz ul Haque;Valeria Brancolini;Hui C. Tsou

  • The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology

    Andrew Leask;David J Abraham

  • Tumor Necrosis Factor α Suppresses the Induction of Connective Tissue Growth Factor by Transforming Growth Factor-β in Normal and Scleroderma Fibroblasts

    David J. Abraham;Xu Shiwen;Carol M. Black;Susan Sa

  • TGFβ, cardiac fibroblasts, and the fibrotic response

    Andrew Leask

  • Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair

    Jinzhu Duan;Costin Gherghe;Dianxin Liu;Eric Hamlett

  • CTGF expression in mesangial cells: Involvement of SMADs, MAP kinase, and PKC

    Youjun Chen;Ingrid E. Blom;Ingrid E. Blom;Susan Sa;Susan Sa;Roel Goldschmeding;Roel Goldschmeding

  • Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen.

    Markella Ponticos;Alan M. Holmes;Xu Shi-Wen;Patricia Leoni

  • Connective tissue growth factor: A new and important player in the pathogenesis of fibrosis

    Andrew Leask;Alan Holmes;David J. Abraham

  • Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients

    Richard Stratton;Xu Shiwen;Giorgia Martini;Alan Holmes

  • Autocrine Overexpression of CTGF Maintains Fibrosis: RDA Analysis of Fibrosis Genes in Systemic Sclerosis

    X. Shi-wen;D. Pennington;A. Holmes;A. Leask

  • Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis.

    Sonali Sonnylal;Xu Shi-Wen;Patricia Leoni;Katherine Naff

Frequent Co-Authors

David Abraham
David Abraham University College London
Christopher P. Denton
Christopher P. Denton University College London
Carol M. Black
Carol M. Black University College London
George Bou-Gharios
George Bou-Gharios University of Liverpool
Karen M. Lyons
Karen M. Lyons University of California, Los Angeles
Frank Beier
Frank Beier University of Western Ontario
Roland M. du Bois
Roland M. du Bois Imperial College London
Jeremy D. Pearson
Jeremy D. Pearson King's College London
Roel Goldschmeding
Roel Goldschmeding Utrecht University
Paul F. Goetinck
Paul F. Goetinck Harvard University

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